Advances in cellular reprogramming: Moving toward a reprieve from immunogenicity

Gallegos, Thomas F.; Sancho‐Martinez, Ignacio; Belmonte, Juan Carlos Izpisúa

doi:10.1016/j.imlet.2013.09.019

Cited by 6 publications

(5 citation statements)

References 43 publications

(39 reference statements)

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“…The therapeutic use of ESCs is ethically controversial. Additionally, in common with iPSCs they are associated with tumorigenicity and immunogenicity [14]. Current advances in reprogramming of iPSCs [15] holds great potential for clinical application, however, epigenetic aspect and genomic aberrations in the reprogrammed cells are still a concern [16].…”

Section: Sources Of 'Building Blocks' For Safe and Predictive Regenerationmentioning

confidence: 99%

Bone Regeneration Using Mesenchymal Stem Cells: Challenges and Future Perspectives in Regenerative Surgery

et al. 2015

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Section: Sources Of 'Building Blocks' For Safe and Predictive Regenerationmentioning

confidence: 99%

Bone Regeneration Using Mesenchymal Stem Cells: Challenges and Future Perspectives in Regenerative Surgery

et al. 2015

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“…This capability opens avenues for developing new generations of biotherapeutic technologies leveraging specific gene functions.The efficacy of exosome-based biotherapies is intricately linked to the source of the parental stem cells. Advances in cell reprogramming technology, particularly in the study of induced pluripotent stem cells (iPSCs), have not only deepened our understanding of stem cell pluripotency and its molecular regulatory mechanisms but have also provided a source of totipotent stem cells capable of extensive proliferation ( Gallegos et al, 2013 ; Aboul-Soud et al, 2021 ).…”

Section: The Advantage and Challenge Of Induced Mesenchymal Stem Cell...mentioning

confidence: 99%

Strategies in product engineering of mesenchymal stem cell-derived exosomes: unveiling the mechanisms underpinning the promotive effects of mesenchymal stem cell-derived exosomes

Jiang,

Lv,

Shen

et al. 2024

Front. Bioeng. Biotechnol.

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Articular cartilage injuries present a significant global challenge, particularly in the aging population. These injuries not only restrict movement due to primary damage but also exacerbate elderly degenerative lesions, leading to secondary cartilage injury and osteoarthritis. Addressing osteoarthritis and cartilage damage involves overcoming several technical challenges in biological treatment. The use of induced mesenchymal stem cells (iMSCs) with functional gene modifications emerges as a solution, providing a more stable and controllable source of Mesenchymal Stem Cells (MSCs) with reduced heterogeneity. Furthermore, In addition, this review encompasses strategies aimed at enhancing exosome efficacy, comprising the cultivation of MSCs in three-dimensional matrices, augmentation of functional constituents within MSC-derived exosomes, and modification of their surface characteristics. Finally, we delve into the mechanisms through which MSC-exosomes, sourced from diverse tissues, thwart osteoarthritis (OA) progression and facilitate cartilage repair. This review lays a foundational framework for engineering iMSC-exosomes treatment of patients suffering from osteoarthritis and articular cartilage injuries, highlighting cutting-edge research and potential therapeutic pathways.

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“…Although the combined knockout of β2m and CIITA are effective from an immune standpoint, it is unlikely that these engineered cells and their derivatives will be used therapeutically as any cell lacking MHC will not be eliminated when infected by a virus or undergo an oncogenic event. Other approaches to obtain immune insensitive ESCs that include the creation of nuclear transfer human hESC cell lines along with common immunosuppressive regimen or costimulatory blockade for the induction of tolerance has been proposed [15–17]. …”

Section: Human Embryonic Stem Cellsmentioning

confidence: 99%

Immune responses to bioengineered organs

Ochando

Charron

Baptista

et al. 2017

Current Opinion in Organ Transplantation

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Purpose of reviewOrgan donation in the United States registered 9079 deceased organ donors in 2015. This high percentage of donations allowed organ transplantation in 29 851 recipients. Despite increasing numbers of transplants performed in comparison with previous years, the numbers of patients that are in need for a transplant increase every year at a higher rate. This reveals that the discrepancy between the demand and availability of organs remains fundamental problem in organ transplantation.Recent findingsDevelopment of bioengineered organs represents a promising approach to increase the pool of organs for transplantation. The technology involves obtaining complex three-dimensional scaffolds that support cellular activity and functional remodeling though tissue recellularization protocols using progenitor cells. This innovative approach integrates cross-thematic approaches from specific areas of transplant immunology, tissue engineering and stem cell biology, to potentially manufacture an unlimited source of donor organs for transplantation.SummaryAlthough bioengineered organs are thought to escape immune recognition, the potential immune reactivity toward each of its components has not been studied in detail. Here, we summarize the host immune response toward different progenitor cells and discuss the potential implications of using nonself biological scaffolds to develop bioengineered organs.

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Advances in cellular reprogramming: Moving toward a reprieve from immunogenicity

Cited by 6 publications

References 43 publications

Bone Regeneration Using Mesenchymal Stem Cells: Challenges and Future Perspectives in Regenerative Surgery

Bone Regeneration Using Mesenchymal Stem Cells: Challenges and Future Perspectives in Regenerative Surgery

Strategies in product engineering of mesenchymal stem cell-derived exosomes: unveiling the mechanisms underpinning the promotive effects of mesenchymal stem cell-derived exosomes

Immune responses to bioengineered organs

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