Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering

Doyle, Michael Eugene; Dalgarno, Kenneth; Masoero, Enrico; Ferreira, Ana Marina

doi:10.1002/bip.23527

Cited by 13 publications

(7 citation statements)

References 184 publications

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“…However, if the final application is connected to harder tissue regeneration, for example, bone regeneration, other strategies must be used because collagen itself is not able to provide the necessary mechanical properties. Since collagen and apatite minerals are the main components of bones, tissue engineering research has been investigating the possibility of combining these materials by using different biomimetic approaches [155].…”

Section: Collagen-based Materialsmentioning

confidence: 99%

“…The nature-inspired biomineralization process, in which organisms operate complex cascades of phenomena generating organic and inorganic hybrid nanostructures (such as bones whose main components are collagen and hydroxyapatite), is hence reproduced However, if the final application is connected to harder tissue regeneration, for example, bone regeneration, other strategies must be used because collagen itself is not able to provide the necessary mechanical properties. Since collagen and apatite minerals are the main components of bones, tissue engineering research has been investigating the possibility of combining these materials by using different biomimetic approaches [155].…”

Section: Collagen-based Materialsmentioning

confidence: 99%

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Recent Advances in the Development of Biomimetic Materials

Ciulla,

Massironi,

Sugni

et al. 2023

Gels

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In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a “bottom-up” artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics.

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Section: Collagen-based Materialsmentioning

confidence: 99%

Section: Collagen-based Materialsmentioning

confidence: 99%

Recent Advances in the Development of Biomimetic Materials

Ciulla,

Massironi,

Sugni

et al. 2023

Gels

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“…SiCHA nanopowders were used as the inorganic component mimicking the composition of native bone [ 12 ]. Hyaluronic acid and collagen type I are important components of ECM [ 7 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Manufacturing of 3D-Printed Hybrid Scaffolds with Polyelectrolyte Multilayer Coating in Static and Dynamic Culture Conditions

Baba Ismail,

Reinwald,

Ferreira

et al. 2024

Materials

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Three-dimensional printing (3DP) has emerged as a promising method for creating intricate scaffold designs. This study assessed three 3DP scaffold designs fabricated using biodegradable poly(lactic) acid (PLA) through fused deposition modelling (FDM): mesh, two channels (2C), and four channels (4C). To address the limitations of PLA, such as hydrophobic properties and poor cell attachment, a post-fabrication modification technique employing Polyelectrolyte Multilayers (PEMs) coating was implemented. The scaffolds underwent aminolysis followed by coating with SiCHA nanopowders dispersed in hyaluronic acid and collagen type I, and finally crosslinked the outermost coated layers with EDC/NHS solution to complete the hybrid scaffold production. The study employed rotating wall vessels (RWVs) to investigate how simulating microgravity affects cell proliferation and differentiation. Human mesenchymal stem cells (hMSCs) cultured on these scaffolds using proliferation medium (PM) and osteogenic media (OM), subjected to static (TCP) and dynamic (RWVs) conditions for 21 days, revealed superior performance of 4C hybrid scaffolds, particularly in OM. Compared to commercial hydroxyapatite scaffolds, these hybrid scaffolds demonstrated enhanced cell activity and survival. The pre-vascularisation concept on 4C hybrid scaffolds showed the proliferation of both HUVECs and hMSCs throughout the scaffolds, with a positive expression of osteogenic and angiogenic markers at the early stages.

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“…The hierarchical structure of bone, consisting of nine levels, provides the skeletal system with the ability to bear weight and withstand mechanical stresses [ 20 ]. Suitable alternatives or substitutes for bone transplants should have similar mechanical strength and degradation rates to natural bone, while also mimicking the composition and structure of the extracellular matrix (ECM), and creating a microenvironment that is conducive to the growth of cells and tissues [ [21] , [22] , [23] , [24] , [25] , [26] ]. Biomimetic materials, such as MC, are engineered to mimic the first two levels of this hierarchy - the chemical composition and structural elements [ 27 ].…”

Section: Introductionmentioning

confidence: 99%