Advances in Application of Marine Bioactive Peptides in Drug Development

Abstract

The ocean is the most resource-rich area on earth. The living environment of marine life is complicated, so that they form a special structure of the active substances. Coupled with the progress of science and technology, people are increasingly concerned about how to find new active substances from marine life, which makes the marine bioactive peptide is widely concerned. Bioactive peptides have a variety of activities, the study shows that these substances have antioxidant, antihypertensive, anti-virus and anti-tumor activity. It has the advantages of low toxicity, high targeting specificity and strong biological activity. At present, some of bioactive peptides extracted from sea cucumbers, conus, ascidians, sponges, marine fungi, molluscs, or analogues derived from these compounds have entered the market or clinical stage. The current research status of marine bioactive peptides is reviewed including their source, synthetic method, chemical structure, activity, mechanism, clinical efficacy and safety. Research prospects in this field are discussed.

Graft modification of cellulose: Methods, properties and applications

“…The cellulose graft copolymers can be self-assembled into single-[140e143] or multi-stimuli [75,136,208,209] responsive micelles in selected solvents depending on the components of the graft copolymers, which have the potential applications as carriers for drug and gene delivery and controlled release [142,143,210]. On the basis of polymer topology and morphology, comb-type cellulose graft copolymers are classified into single-, dual-, block-, centipede-and dendritic-like grafts [19]. The multiple functions of cellulose graft copolymers, such as hydrophilic, hydrophobic, amphiphilic, environmental responsive or polyelectrolyte, can be synthesized by designing the chemical structures of both the cellulosic backbone and the side chains.…”

Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities

“…A number of reviews on marine peptides have appeared in recent years, focusing mainly on their biological activities, applications and biosynthesis as well as isolation procedures [ 16 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. In this review, several works related to the methods used for determination of the absolute configuration of marine peptides by chromatographic methods are presented in different sections according to the source of the marine peptides.…”