Application of marine natural products in drug research

Lu, Wei; Li, Hui‐Jing; Li, Qinying; Wu, Yan‐Chao

doi:10.1016/j.bmc.2021.116058

Cited by 80 publications

(72 citation statements)

References 191 publications

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“…Furthermore, the uniqueness of marine life is reflected by the fact that only a small fraction of the 30,000 marine natural products (MNPs) known at present can also be found in terrestrial sources [1]. Additionally, the isolation and investigation of MNPs is a rapidly expanding field of research at the interface of biology and chemistry [2][3][4][5][6][7][8][9][10]. Looking back to 2009, when only 20,000 MNPs were known, an impressive increase of 50% has been achieved in the past 11 years, which highlights the importance of the marine habitat in this context [11].…”

Section: Introductionmentioning

confidence: 99%

“…Among the marine alkaloids, which are largely composed of nitrogen-containing heterocycles, the pyrroles form a large group of intriguing natural products which occur in marine organisms ranging from microbes over algae and sponges to animals. Their structural diversity including terpenoid-, polyketide-, carbohydrate-, lipid-, and peptideframeworks [7,12] accompanied by attractive biological properties, has spurred a considerable interest of chemists [6,[13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Marine Pyrrole Alkaloids

2021

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Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Marine Pyrrole Alkaloids

2021

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“…In 2020, there were eight marine-derived products approved as drugs by the United States Food and Drug Administration (US FDA) or the European Medicines Agency (EMA) [22]. In addition to that, tens of drug candidates are in phase I-III of drug development, highlighting the increasing potential of MNPs [16,22,23]. Once the compounds have been obtained, their complex structures and their molecular targets can be difficult to establish, particularly when the amount of compounds is very small [15,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases

Llorach-Parés

Nonell-Canals²,

Ávila

et al. 2022

Marine Drugs

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Computer-aided drug design (CADD) techniques allow the identification of compounds capable of modulating protein functions in pathogenesis-related pathways, which is a promising line on drug discovery. Marine natural products (MNPs) are considered a rich source of bioactive compounds, as the oceans are home to much of the planet’s biodiversity. Biodiversity is directly related to chemodiversity, which can inspire new drug discoveries. Therefore, natural products (NPs) in general, and MNPs in particular, have been used for decades as a source of inspiration for the design of new drugs. However, NPs present both opportunities and challenges. These difficulties can be technical, such as the need to dive or trawl to collect the organisms possessing the compounds, or biological, due to their particular marine habitats and the fact that they can be uncultivable in the laboratory. For all these difficulties, the contributions of CADD can play a very relevant role in simplifying their study, since, for example, no biological sample is needed to carry out an in-silico analysis. Therefore, the amount of natural product that needs to be used in the entire preclinical and clinical study is significantly reduced. Here, we exemplify how this combination between CADD and MNPs can help unlock their therapeutic potential. In this study, using a set of marine invertebrate molecules, we elucidate their possible molecular targets and associated therapeutic potential, establishing a pipeline that can be replicated in future studies.

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“…While natural product research includes plant, marine animal and microbe sources, more recently, marine flora and fauna have afforded an exciting number of potential therapeutic agents that are currently in preclinical and clinical evaluation due to promising biological activities with in vivo and in vitro assays [1][2][3][4][5][6][7]. Such drug leads have also significantly contributed to our understanding of cellular biochemical processes.…”

Section: Introductionmentioning

confidence: 99%

Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide

et al. 2021

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The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In addition to these newly characterized compounds, ten known metabolites (3–12) were isolated. Previously reported compounds were elucidated by literature comparison of spectroscopic data (1D and 2D NMR as well as MS data). In vitro antimicrobial activity was investigated for compounds (1–12) against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger. Compound 5 showed antimicrobial activity against all assayed microorganisms.

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Application of marine natural products in drug research

Cited by 80 publications

References 191 publications

Marine Pyrrole Alkaloids

Marine Pyrrole Alkaloids

Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases

Paralemnolins X and Y, New Antimicrobial Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoide

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