Advances and Practices of Bioprocess Scale-up

Xia, Jian; Wang, Guan; Lin, Jihan; Wang, Yonghong; Chu, Ju; Zhuang, Yingping; Zhang, Siliang

doi:10.1007/10_2014_293

Cited by 20 publications

(19 citation statements)

References 71 publications

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“…The process considerations for efficient scale‐up and implementation of enzymatic processes were mentioned. Some of the scale‐up studies include C. cylindracea lipase‐catalyzed bioconversion of palm oil mill effluents, R. oryzae lipase‐catalyzed modification of maize starch with palmitic acid . According to the recent reviews, industrial scale‐up of lipase‐catalyzed bioprocesses find immense applications in the pharmaceutical and chemical industries leading to the synthesis of many chiral and biotransformed end products which provide eco‐friendly alternatives to the metallo and organo catalysis that require extreme operating conditions .…”

Section: Major Challenges With Respect To Industrial Implementationmentioning

confidence: 99%

“…Some of the scale-up studies include C. cylindracea lipase-catalyzed bioconversion of palm oil mill effluents, 299 R. oryzae lipase-catalyzed modification of maize starch with palmitic acid. 300 According to the recent reviews, industrial scale-up of lipase-catalyzed bioprocesses find immense applications in the pharmaceutical and chemical industries leading to the synthesis of many chiral and biotransformed end products which provide eco-friendly alternatives to the metallo and organo catalysis that require extreme operating conditions. 10 Some of the pharmaceutical lipase biocatalysis reactions that have been subjected to scale-up include resolution of chiral precursors for synthesis of diltiazem, synthesis of wax esters such as myristylmyristate or cetylricinoleate for cosmetics and (1S,3S)-3-aminocyclohexanol.…”

Section: Process Optimization Modeling and Scale-up Studiesmentioning

confidence: 99%

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Recent advances on sources and industrial applications of lipases

Sarmah

Revathi

Sheelu

et al. 2017

Biotechnology Progress

270

123

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Lipases are the industrially important biocatalysts, which are envisioned to have tremendous applications in the manufacture of a wide range of products. Their unique properties such as better stability, selectivity and substrate specificity position them as the most expansively used industrial enzymes. The research on production and applications of lipases is ever growing and there exists a need to have a latest review on the research findings of lipases. The present review aims at giving the latest and broadest overall picture of research and development on lipases by including the current studies and progressions not only in the diverse industrial application fields of lipases, but also with regard to its structure, classification and sources. Also, a special emphasis has been made on the aspects such as process optimization, modeling, and design that are very critical for further scale-up and industrial implementation. The detailed tabulations provided in each section, which are prepared by the exhaustive review of current literature covering the various aspects of lipase including its production and applications along with example case studies, will serve as the comprehensive source of current advancements in lipase research. This review will be very useful for the researchers from both industry as well as academia in promoting lipolysis as the most promising approaches to intensified, greener and sustainable processes. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 34:5-28, 2018.

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Section: Major Challenges With Respect To Industrial Implementationmentioning

confidence: 99%

Section: Process Optimization Modeling and Scale-up Studiesmentioning

confidence: 99%

Recent advances on sources and industrial applications of lipases

Sarmah

Revathi

Sheelu

et al. 2017

Biotechnology Progress

270

123

View full text Add to dashboard Cite

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“…It is indeed a permanent task and challenge for biochemical engineers to discover and gain more knowledge of cell kinetics and bioreactor fluid dynamics, and of the interaction between these two parts, in order to accelerate the technology transition from laboratory study to real industrial application. Xia et al [6] highlighted the methodology for process optimization and bioreactor scale-up by integrating fluid dynamics with kinetics. A comprehensive discussion on advantages and challenges of the model-driven scale-up method was also given.…”

Section: Prefacementioning

confidence: 99%

Bioreactor Engineering Research and Industrial Applications II

Jie¹,

Ye²,

Zhong³

2016

Advances in Biochemical Engineering/Biotechnology

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Aims and ScopeThis book series reviews current trends in modern biotechnology and biochemical engineering. Its aim is to cover all aspects of these interdisciplinary disciplines, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, molecular biology, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, volumes are edited by well-known guest editors. The series editor and publisher will, however, always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made.Printed on acid-free paper Springer-Verlag GmbH Berlin Heidelberg is part of Springer Science+Business Media (www.springer.com) PrefaceBioreactor is the core of industrial biotechnology practice. Traditional bioreactors include enzyme reactors and microbial fermentors, but recent research activities on bioreactors have significantly extended to various scales of them whether in a large natural ecology system or at a micro-scale level of nano sizes. Although bioreactor and bioreactor technology seem to be a traditional area of biochemical engineering and biotechnology, recently some new types of bioreactors have still been developed and applied into industrial practice. New methodology concepts on bioreactor research have also been proposed on the basis of cell biology and metabolic engineering. Therefore, in this context, this special volume is dedicated to bioreactor engineering to make the old new, and six invited chapters ranging from novel design of bioreactors to methodologies of bioreactor/bioprocess analysis and optimization are included.As well know...

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“…To meet the ever‐growing demand for various life necessities, there has been an upward trend of biobased production which has capitalized on microbial life as cell factories to synthesize therapeutic proteins and bulk chemicals for a sustainable economy and environment (Xia et al, 2016). However, transitioning from a small laboratory scale to large industrial bioprocesses is always complicated by environmental fluctuations caused by the nonhomogenous mixing encountered in large‐scale fermentation (Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

A model‐driven approach towards rational microbial bioprocess optimization

Yeoh

Jayaraman

Tan

et al. 2020

Biotech & Bioengineering

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Due to sustainability concerns, bio-based production capitalizing on microbes as cell factories is in demand to synthesize valuable products. Nevertheless, the nonhomogenous variations of the extracellular environment in bioprocesses often challenge the biomass growth and the bioproduction yield. To enable a more rational bioprocess optimization, we have established a model-driven approach that systematically integrates experiments with modeling, executed from flask to bioreactor scale, and using ferulic acid to vanillin bioconversion as a case study. The impacts of mass transfer and aeration on the biomass growth and bioproduction performances were examined using minimal small-scale experiments. An integrated model coupling the cell factory kinetics with the three-dimensional computational hydrodynamics of bioreactor was developed to better capture the spatiotemporal distributions of bioproduction. Full-factorial predictions were then performed to identify the desired operating conditions. A bioconversion yield of 94% was achieved, which is one of the highest for recombinant Escherichia coli using ferulic acid as the precursor.

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Advances and Practices of Bioprocess Scale-up

Cited by 20 publications

References 71 publications

Recent advances on sources and industrial applications of lipases

Recent advances on sources and industrial applications of lipases

Bioreactor Engineering Research and Industrial Applications II

A model‐driven approach towards rational microbial bioprocess optimization

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