Advances and potential of omics studies for understanding the development of food allergy

Sindher, Sayantani; Chin, Andrew R.; Aghaeepour, Nima; Prince, Lawrence S.; Maecker, Holden T.; Shaw, Gary M.; Stevenson, David K.; Nadeau, Kari; Snyder, M; Khatri, Purvesh; Boyd, Scott D.; Winn, Virginia D.; Angst, Martin S.; Chinthrajah, R. Sharon

doi:10.3389/falgy.2023.1149008

Cited by 7 publications

(10 citation statements)

References 99 publications

(88 reference statements)

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“…Advancements in technology, including transcriptomics, genomics, and proteomics, open new avenues for exploring potential biomarkers of atopic march and atopic multimorbidity [92]. The idea of biomarkers presents a key for future personal and precise treatment.…”

Section: Biomarkers Of the Atopic Multimorbiditymentioning

confidence: 99%

Atopic March or Atopic Multimorbidity—Overview of Current Research

Mrkić Kobal,

Plavec,

Vlašić Lončarić

et al. 2023

Medicina

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The atopic march encompasses a sequence of allergic conditions, including atopic dermatitis, food allergy, allergic rhinitis, and asthma, that frequently develop in a sequential pattern within the same individual. It was introduced as a conceptual framework aimed at elucidating the developmental trajectory of allergic conditions during childhood. Following the introduction of this concept, it was initially believed that the atopic march represented the sole and definitive trajectory of the development of allergic diseases. However, this perspective evolved with the emergence of new longitudinal studies, which revealed that the evolution of allergic diseases is far more intricate. It involves numerous immunological pathological mechanisms and may not align entirely with the traditional concept of the atopic march. The objective of our review is to portray the atopic march alongside other patterns in the development of childhood allergic diseases, with a specific emphasis on the potential for a personalized approach to the prevention, diagnosis, and treatment of atopic conditions.

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Section: Biomarkers Of the Atopic Multimorbiditymentioning

confidence: 99%

Atopic March or Atopic Multimorbidity—Overview of Current Research

Mrkić Kobal,

Plavec,

Vlašić Lončarić

et al. 2023

Medicina

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“…Furthermore, while the adaptive immunity underlying food allergies and therapeutic responses have been studied extensively, little is known about the immunometabolism (the interaction between immunity and metabolism) of the modification of tolerance to food allergens. [7][8][9] Metabolomics, defined as study of small molecule cellular substrates, intermediates and products of cellular metabolism, can be used to gauge the physiologic state of an organism and can reflect the interaction of the genome, transcriptome, proteome, microbiome, and environmental influences on disease. 10,11 Studies support the utility of metabolomic analyses in identifying pathways associated with food allergy, while several investigations have explored the evolution of metabolomic profiles on other types of aeroallergen sublingual and subcutaneous immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…10,11 Studies support the utility of metabolomic analyses in identifying pathways associated with food allergy, while several investigations have explored the evolution of metabolomic profiles on other types of aeroallergen sublingual and subcutaneous immunotherapy. 9,[12][13][14][15][16][17][18][19][20][21] To date, one study has examined water soluble metabolites in the stool in the setting of food immunotherapy, and none have studied the plasma metabolome in humans. 22 .…”

Section: Introductionmentioning

confidence: 99%

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Metabolomics of IgE-Mediated Food Allergy and Oral Immunotherapy Outcomes based on Metabolomic Profiling

Virkud,

Styles,

Kelly

et al. 2024

Preprint

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BackgroundThe immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown.ObjectiveTo identify novel pathways associated with tolerance in food allergy, we used metabolomic profiling to find pathways important for food allergy in multi-ethnic cohorts and responses to OIT.MethodsUntargeted plasma metabolomics data were generated from the VDAART healthy infant cohort (N=384), a Costa Rican cohort of children with asthma (N=1040), and a peanut OIT trial (N=20) evaluating sustained unresponsiveness (SU, protection that lasts after therapy) versus transient desensitization (TD, protection that ends immediately afterwards). Generalized linear regression modeling and pathway enrichment analysis identified metabolites associated with food allergy and OIT outcomes.ResultsCompared with unaffected children, those with food allergy were more likely to have metabolomic profiles with altered histidines and increased bile acids. Eicosanoids (e.g., arachidonic acid derivatives) (q=2.4×10−20) and linoleic acid derivatives (q=3.8×10−5) pathways decreased over time on OIT. Comparing SU versus TD revealed differing concentrations of bile acids (q=4.1×10−8), eicosanoids (q=7.9×10−7), and histidine pathways (q=0.015). In particular, the bile acid lithocholate (4.97[1.93,16.14], p=0.0027), the eicosanoid leukotriene B4 (3.21[1.38,8.38], p=0.01), and the histidine metabolite urocanic acid (22.13[3.98,194.67], p=0.0015) were higher in SU.ConclusionsWe observed distinct profiles of bile acids, histidines, and eicosanoids that vary among patients with food allergy, over time on OIT and between SU and TD. Participants with SU had higher levels of metabolites such as lithocholate and urocanic acid, which have immunomodulatory roles in key T-cell subsets, suggesting potential mechanisms of tolerance in immunotherapy.Key Messages–Compared with unaffected controls, children with food allergy demonstrated higher levels of bile acids and distinct histidine/urocanic acid profiles, suggesting a potential role of these metabolites in food allergy.–In participants receiving oral immunotherapy for food allergy, those who were able to maintain tolerance-even after stopping therapyhad lower overall levels of bile acid and histidine metabolites, with the exception of lithocholic acid and urocanic acid, two metabolites that have roles in T cell differentiation that may increase the likelihood of remission in immunotherapy.Capsule summaryThis is the first study of plasma metabolomic profiles of responses to OIT in individuals with IgE-mediated food allergy. Identification of immunomodulatory metabolites in allergic tolerance may help identify mechanisms of tolerance and guide future therapeutic development.

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“…It offers a comprehensive view of the functional proteins present, which is crucial for understanding various biological processes. These methodologies permit the detection of food parasites [11], food authenticity investigation [12], food microorganism detection [13], recognition of food allergens [14], food processing analysis [15], by-product safety [16] and systems biology studies [17], among others [18]. Thus, these approaches are a beneficial proposal for food science findings, where agencies, investigation laboratories, food companies, and controlling institutions are merging efforts to obtain essential understandings about food safety.…”

mentioning

confidence: 99%