Atopic March or Atopic Multimorbidity—Overview of Current Research

Abstract

The atopic march encompasses a sequence of allergic conditions, including atopic dermatitis, food allergy, allergic rhinitis, and asthma, that frequently develop in a sequential pattern within the same individual. It was introduced as a conceptual framework aimed at elucidating the developmental trajectory of allergic conditions during childhood. Following the introduction of this concept, it was initially believed that the atopic march represented the sole and definitive trajectory of the development of allergic diseases. However, this perspective evolved with the emergence of new longitudinal studies, which revealed that the evolution of allergic diseases is far more intricate. It involves numerous immunological pathological mechanisms and may not align entirely with the traditional concept of the atopic march. The objective of our review is to portray the atopic march alongside other patterns in the development of childhood allergic diseases, with a specific emphasis on the potential for a personalized approach to the prevention, diagnosis, and treatment of atopic conditions.

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

“…While recent meta-analyses ( 11 – 13 ) have indicated a bidirectional association between asthma and headache disorder, our study extends this understanding. The concept of the atopic march describes the progression of atopic disorders from AD in infancy to allergic rhinitis and asthma in childhood ( 32 ). Therefore, it is plausible that AD might also elevate the risk of headache disorder.…”