Advancements in the development of subunit influenza vaccines

Zhang, Naru; Zheng, Bo‐Jian; Lu, Lu; Zhou, Yusen; Jiang, Shibo; Du, Lanying

doi:10.1016/j.micinf.2014.12.006

Cited by 47 publications

(43 citation statements)

References 117 publications

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“…Among these genera, only influenza A and influenza B viruses cause clinical diseases. Influenza B viral infections usually cause localized outbreaks, whereas influenza A virus is the primary pathogen for human infections and, thus, the major cause of large influenza epidemics and pandemics 44 . Based on the glycoproteins hemagglutinin (HA) and neuraminidase (NA), which are located on the viral surface, influenza A viruses are divided into various subtypes.…”

Section: Influenza Virus and Its Diagnostic Approachesmentioning

confidence: 99%

“…Based on the glycoproteins hemagglutinin (HA) and neuraminidase (NA), which are located on the viral surface, influenza A viruses are divided into various subtypes. Until now, 18 HA (H1‐H18) and 11 NA (N1‐N11) subtypes have been identified 44 . A number of diagnostic approaches, including virus isolation, as well as some emerging molecular‐based approaches, have been used to detect influenza viruses in clinical laboratories.…”

Section: Influenza Virus and Its Diagnostic Approachesmentioning

confidence: 99%

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Recent advances in the detection of respiratory virus infection in humans

Zhang

Wang

Deng

et al. 2020

Journal of Medical Virology

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429

363

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Respiratory tract viral infection caused by viruses or bacteria isone of the most common diseases in human worldwide, while those caused by emerging viruses, such as the novel coronavirus, 2019-nCoV that caused the pneumonia outbreak in Wuhan, China most recently, have posed great threats to global public health. Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people's lives, stop the epidemics, and avoid unnecessary use of antibiotics. Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. With the development of modern technologies, new diagnostic strategies, including multiplex nucleic acid amplification and microarray-based assays, are emerging. This review summarizes currently available and novel emerging diagnostic methods for the detection of common respiratory viruses, such as influenza virus, human respiratory syncytial virus, coronavirus, human adenovirus, and human rhinovirus. Multiplex assays for simultaneous detection of multiple respiratory viruses are also described. It is anticipated that such data will assist researchers and clinicians to develop appropriate diagnostic strategies for timely and effective detection of respiratory virus infections. K E Y W O R D S adenovirus, coronavirus, diagnostic methods, influenza virus, respiratory syncytial virus, respiratory viral infection, rhinovirus

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Section: Influenza Virus and Its Diagnostic Approachesmentioning

confidence: 99%

Section: Influenza Virus and Its Diagnostic Approachesmentioning

confidence: 99%

Recent advances in the detection of respiratory virus infection in humans

Zhang

Wang

Deng

et al. 2020

Journal of Medical Virology

Self Cite

429

363

View full text Add to dashboard Cite

show abstract

“…The N-terminal domain is followed by a short linker that was proposed to contain a zinc binding site36 and the C-terminal domain. The latter dimerizes in vitro 37, is essential for M1 polymerization38 and provides a link to the ribonucleoprotein (RNP)32. Full-length M1 from influenza virus A forms an elongated structure39 containing a compact N-terminal domain and an extended and partially flexible C-terminal domain under low pH conditions40.…”

mentioning

confidence: 99%

The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model

Saletti

Radzimanowski

Effantin

et al. 2017

Sci Rep

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Matrix proteins from enveloped viruses play an important role in budding and stabilizing virus particles. In order to assess the role of the matrix protein M1 from influenza C virus (M1-C) in plasma membrane deformation, we have combined structural and in vitro reconstitution experiments with model membranes. We present the crystal structure of the N-terminal domain of M1-C and show by Small Angle X-Ray Scattering analysis that full-length M1-C folds into an elongated structure that associates laterally into ring-like or filamentous polymers. Using negatively charged giant unilamellar vesicles (GUVs), we demonstrate that M1-C full-length binds to and induces inward budding of membrane tubules with diameters that resemble the diameter of viruses. Membrane tubule formation requires the C-terminal domain of M1-C, corroborating its essential role for M1-C polymerization. Our results indicate that M1-C assembly on membranes constitutes the driving force for budding and suggest that M1-C plays a key role in facilitating viral egress.

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“…Conjugate vaccines consist of bacterial polysaccharides linked to a recognizable antigen, thus stimulating the immune system to react to the polysaccharide coating. 16,17 The choice of which vaccine to give depends on patient's age, comorbidities, and other factors. For example, the MMR vaccine is generally not given before 12 months of age because maternal antibodies that convey passive immunity may still be present and render the vaccine less effective.…”

Section: Mechanisms Of Vaccine Protectionmentioning

confidence: 99%

Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications

Porteous

Hanson

Sueda

et al. 2016

Anesthesia &Amp; Analgesia

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Vaccine-preventable diseases (VPDs) such as measles and pertussis are becoming more common in the United States. This disturbing trend is driven by several factors, including the antivaccination movement, waning efficacy of certain vaccines, pathogen adaptation, and travel of individuals to and from areas where disease is endemic. The anesthesia-related manifestations of many VPDs involve airway complications, cardiovascular and respiratory compromise, and unusual neurologic and neuromuscular symptoms. In this article, we will review the presentation and management of 9 VPDs most relevant to anesthesiologists, intensivists, and other hospital-based clinicians: measles, mumps, rubella, pertussis, diphtheria, influenza, meningococcal disease, varicella, and poliomyelitis. Because many of the pathogens causing these diseases are spread by respiratory droplets and aerosols, appropriate transmission precautions, personal protective equipment, and immunizations necessary to protect clinicians and prevent nosocomial outbreaks are described.

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Advancements in the development of subunit influenza vaccines

Cited by 47 publications

References 117 publications

Recent advances in the detection of respiratory virus infection in humans

Recent advances in the detection of respiratory virus infection in humans

The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model

Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications

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