Advancements in mass spectrometry as a tool for clinical analysis: part II

Heaney, Liam M.

doi:10.1515/cclm-2020-0259

Cited by 5 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent applications of MS in the development of environmental monitoring systems such as single particle aerosol-MS (SPA-MS), single photon ionization-MS (SPI-MS), volatile organic compounds (VOCs) analyzers, and so on, have demonstrated its multipurpose uses [45,46]. The development of the MS-imaging system is a turning point in the scientific world since it allows for precise medical diagnosis of tumors, cancer, and other diseases by analyzing complex biomolecules [47][48][49][50]. Because the MS approach allows for the direct identification and quantification of analytes of interest, space scientists and technologists are employing MSbased analytical techniques [51,52].…”

Section: Introductionmentioning

confidence: 99%

Hollow cathode discharge ionization mass spectrometry: detection, quantification and gas phase ion-molecule reactions of explosives and related compounds

Hong

Habib

et al. 2022

Preprint

View full text Add to dashboard Cite

Mass spectrometry (MS) has become an essential analytical method in every sector of science and technology. Because of its unique ability to provide direct molecular structure information on analytes, an extra method is rarely required. This review describes fabrication of a variable-pressure hollow cathode discharge (HCD) ion source for MS in detection, quantification and investigation of gas-phase ion molecule reactions of explosives and related compounds using air as a carrier gas. The HCD ion source has been designed in such a way that by altering the ion source pressures, the system can generate both HCD and conventional GD. This design enables for the selective detection and quantification of explosives at trace to ultra-trace levels. The pressure-dependent HCD ion source has also been used to investigate ion-molecule reactions in the gas phase of explosives and related compounds. The mechanism of ion formation in explosive reactions is also discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Hollow cathode discharge ionization mass spectrometry: detection, quantification and gas phase ion-molecule reactions of explosives and related compounds

Hong

Habib

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Hollow Cathode Discharge Ionization Mass Spectrometry: Detection, Quantification and Gas Phase Ion-Molecule Reactions of Explosives and Related Compounds

Hong

Habib

et al. 2022

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine

Hörber

Peter

Lehmann

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

ObjectivesDue to its high specificity, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is considered the gold standard in diagnostic areas such as therapeutic monitoring of immunosuppressive drugs (ISDs). However, many laboratories still rely on immunoassays for ISD quantification in a tradeoff between analytical performance and the advantages of fully automated analyzers – shorter turnaround times, greater ease of use, and 24/7 availability.MethodsThe LC-MS/MS-based Thermo Scientific™ Cascadion™ SM Immunosuppressant Panel was evaluated for >6 months in the routine laboratory of a university hospital. We assessed the analytical performance of the panel and compared it to conventional LC-MS/MS as well as to immunoassays (cyclosporine A, sirolimus, tacrolimus (Siemens) and everolimus (Thermo Fisher)). In addition, both ISD panel and Cascadion analyzer were scrutinized with regards to, e.g., turnaround time, usability, and robustness.ResultsAll ISDs showed high linearity and precision (CV≤6%) and a good correlation with conventional LC-MS/MS. The mean deviation to the immunoassays was 17–19% and negative for all ISDs except everolimus with a positive 19% bias. No weak points were revealed when challenging assay and system with, e.g., high haematocrit, sedimented whole blood or priority samples. The Cascadion integrated well into our 24/7 routine and could easily be operated simultaneously with several other analyzers by technical staff without LC-MS experience.ConclusionsThe ISD panel showed excellent analytical performance and demonstrated that a fully automated LC-MS-based analysis starting from primary samples is feasible, suggesting that LC-MS could become an integral part of 24/7 diagnostics in the near future.

show abstract

Advancements in mass spectrometry as a tool for clinical analysis: part II

Cited by 5 publications

References 21 publications

Hollow cathode discharge ionization mass spectrometry: detection, quantification and gas phase ion-molecule reactions of explosives and related compounds

Hollow cathode discharge ionization mass spectrometry: detection, quantification and gas phase ion-molecule reactions of explosives and related compounds

Hollow Cathode Discharge Ionization Mass Spectrometry: Detection, Quantification and Gas Phase Ion-Molecule Reactions of Explosives and Related Compounds

Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine

Contact Info

Product

Resources

About