Advancements in genomic medicine and the need for updated regional clinical practice guidelines in the field of hepatology

Panduro, Arturo; Román, Sonia

doi:10.1016/j.aohep.2019.12.002

Cited by 13 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…51,52 Regional clinical practice guidelines to treat these inter-related chronic diseases require considering the genetic, dietary, and cultural determinants that have a significant impact on clinical outcomes. 53 Therefore, comparative research on the impact of unhealthy dietary changes on the development of dyslipidemia and T2DM in populations with differences in the distribution of ApoE alleles is warranted.…”

Section: Discussionmentioning

confidence: 99%

<p>Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico</p>

González-Aldaco¹,

Román²,

Torres-Reyes³

et al. 2020

DMSO

Self Cite

View full text Add to dashboard Cite

This study aimed to analyze the association of the apolipoprotein E (ApoE) polymorphisms with type 2 diabetes mellitus (T2DM) among the admixed population of West Mexico. Patients and Methods: ApoE genotypes were determined in 168 T2DM patients and 449 non-diabetic control subjects from the general admixed population of West Mexico. The nondiabetic subjects were stratified according to body mass index (BMI) in normal weight (n=186), overweight (n=138), and obesity (n=125). ApoE genotypes were assessed by using a TaqMan allelic discrimination assay, insulin resistance (IR) by HOMA-IR, and biochemistry with a dry chemistry assay. Results: The rate of dyslipidemias and IR increased by BMI category among the control subjects. The greater shift in the prevalence of dyslipidemia was observed from normal weight (51.4%) to overweight (76.6%), p<0.01. Normal weight or obese e4 allele carriers had a higher level of total cholesterol and hypercholesterolemia than non-e4 carriers. Among the T2DM patients, the e2 carriers had abnormal HOMA-IR value than the non-e2 carriers (p=0.002). Comparatively, between the T2DM patients vs non-diabetics, the e2e3 genotype or e2 allele conferred a higher risk for T2DM (adjusted OR= 2.36, 95% CI 1.28-4.34, p=0.006 and adjusted OR=2.1, 95% Cl 1.20-3.79, p=0.009, respectively). Conclusion: The ApoE e2 allele was associated with IR and the risk of T2DM in subjects from the general admixed population of West Mexico.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico</p>

González-Aldaco¹,

Román²,

Torres-Reyes³

et al. 2020

DMSO

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lastly, the major benefit of re-engineering the educational curriculum is to promote the formation of researchers in LATAM and Mexico, thus creating novel knowledge in the field of MedPer-Nut in this region ( 145 ). In this sense, transforming the present clinical practice guidelines is an ongoing challenge because most recommendations are based on studies carried out in foreign populations ( 146 ). As illustrated in Figure 4 , the genetic profile interacting with the environmental factors that concur in Mexico, may not replicate in other regions and vice versa.…”

Section: Genomic Educationmentioning

confidence: 99%

“…Likewise, hepatology was not born when most medical specialties were created (142). Although some hepatology postgraduate courses have been sponsored by the associations for the study of the liver to update medical specialists, pre-graduate doctors and nutritionists need to understand the molecular physiology of the liver, while more postgraduate courses in MedPer-Nut are required to advance in Genomic Hepatology (143). Furthermore, the capability to analyze hundreds or thousands of these genes simultaneously leads us to largescale data management (Big Data) and specialized bioinformatics (machine learning and other artificial intelligence methods), together with advanced omics biotechnologies (epigenetics, metagenomics, proteomics, lipidomics, and metabolomics), digital media, and electronic medical records (144).…”

Section: Genomic Educationmentioning

confidence: 99%

Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico

Panduro,

Roman,

Mariscal-Martinez

et al. 2024

Front. Nutr.

Self Cite

View full text Add to dashboard Cite

Chronic liver disease is a global health issue. Patients with chronic liver disease require a fresh approach that focuses on the genetic and environmental factors that contribute to disease initiation and progression. Emerging knowledge in the fields of Genomic Medicine and Genomic Nutrition demonstrates differences between countries in terms of genetics and lifestyle risk factors such as diet, physical activity, and mental health in chronic liver disease, which serves as the foundation for the implementation of Personalized Medicine and Nutrition (PerMed-Nut) strategies. Most of the world’s populations have descended from various ethnic groupings. Mexico’s population has a tripartite ancestral background, consisting of Amerindian, European, and African lineages, which is common across Latin America’s regional countries. The purpose of this review is to discuss the genetic and environmental components that could be incorporated into a PerMed-Nut model for metabolic-associated liver disease, viral hepatitis B and C, and hepatocellular carcinoma in Mexico. Additionally, the implementation of the PerMed-Nut approach will require updated medicine and nutrition education curricula. Training and equipping future health professionals and researchers with new clinical and investigative abilities focused on preventing liver illnesses in the field of genomic hepatology globally is a vision that clinicians and nutritionists should be concerned about.

show abstract

How far is Mexico from Viral Hepatitis Global Health Sector Strategy 2030 targets

García-Sepúlveda

Laguna-Meraz

Panduro

2020

Annals of Hepatology

View full text Add to dashboard Cite

Advancements in genomic medicine and the need for updated regional clinical practice guidelines in the field of hepatology

Cited by 13 publications

References 13 publications

<p>Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico</p>

<p>Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico</p>

Personalized medicine and nutrition in hepatology for preventing chronic liver disease in Mexico

How far is Mexico from Viral Hepatitis Global Health Sector Strategy 2030 targets

Contact Info

Product

Resources

About