How far is Mexico from Viral Hepatitis Global Health Sector Strategy 2030 targets

García-Sepúlveda, Christian A.; Laguna-Meraz, Saul; Panduro, Arturo

doi:10.1016/j.aohep.2020.02.003

Cited by 8 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HBV vaccine has been included in Mexico’s national vaccination program since 1999. According to data up to 2017, vaccination coverage for HBV with three doses in newborns, has been reported between 84 and 89% [ 27 , 28 ]. However, the coverage percentages vary in older individuals.…”

Section: Discussionmentioning

confidence: 99%

Donated Blood Screening for HIV, HCV and HBV by ID-NAT and the Residual Risk of Iatrogenic Transmission in a Tertiary Care Hospital Blood Bank in Puebla, Mexico

Sosa-Jurado,

Palencia-Lara,

Xicoténcatl-Grijalva

et al. 2023

Viruses

View full text Add to dashboard Cite

Hepatitis C virus (HCV), human immunodeficiency virus (HIV) and hepatitis B virus (HBV) can be transmitted by blood transfusion. Most transmission occurs during the acute viremic phase (AVP), before antibody development. To reduce transmission risk, individual donor nucleic acid testing (ID-NAT) is used. In Puebla, Mexico, serological tests and ID-NAT have been applied to screen blood donors and detect individuals in AVP. In the present study, 106,125 blood donors’ data in two periods (2012–2015 and 2017–2019) were analyzed. The residual risk (RR) values were calculated considering ID-NAT results. The RR for HIV was 14 in 1 million donations or 1 in 71,428, the RR for HVC was 6.8 in 1 million donations or 1 in 147,058 and, for HBV, it was 156 in 1 million donations, or 1 in 6410. Previously, it was predicted that the transmission RR of these viruses would be reduced in Mexico through better screening with NAT. The use of ID-NAT has, indeed, increased the safety of blood reserves for HIV and HCV. However, more research is needed to determine why the residual risk of HBV did not decrease as much over the study period. ID-NAT is an important complementary tool for blood donor screening that should be implemented.

show abstract

Section: Discussionmentioning

confidence: 99%

Donated Blood Screening for HIV, HCV and HBV by ID-NAT and the Residual Risk of Iatrogenic Transmission in a Tertiary Care Hospital Blood Bank in Puebla, Mexico

Sosa-Jurado,

Palencia-Lara,

Xicoténcatl-Grijalva

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Treatment of HCV infection has advanced notably in the last decade in terms of developing more effective therapies such as the direct-acting antiviral agents (DAAs) for the promising eradication of HCV while reducing the risk factors involved in liver damage, including necroinflammation, steatosis, cirrhosis, and hepatocellular carcinoma [61]. How-ever, patients living in low-income and middle-income countries such as Latin America do not have immediate access to DDA therapy [62]. Therefore, lifestyle modifications, including diet, are validated resources to manage patients with liver disease [27,30].…”

Section: Discussionmentioning

confidence: 99%

Adherence to a Fish-Rich Dietary Pattern Is Associated with Chronic Hepatitis C Patients Showing Low Viral Load: Implications for Nutritional Management

et al. 2021

Self Cite

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infection is influenced by genetic (e.g., APOE polymorphisms) and environmental factors between the virus and the host. HCV modulates the host’s lipid metabolism but dietary components influence lipids and in vitro HCV RNA replication. Few data exist on the role of dietary features or patterns (DPs) in HCV infection. Herein, we aimed to evaluate the nutritional profiles of chronic HCV (CHC) and spontaneous clearance (SC) Mexican patients in the context of APOE alleles and their correlation with HCV-related variables. The fibrosis-related APOEε3 allele prevailed in CHC and SC patients, who had four DPs (“meat and soft drinks”, DP1; “processed animal and fried foods”, DP2; “Mexican-healthy”, DP3; and “fish-rich”, DP4). In CHC subjects, polyunsaturated fatty acid intake (PUFA ≥ 4.9%) was negatively associated, and fiber intake (≥21.5 g/d) was positively associated with a high viral load (p < 0.036). High adherence to fish-rich DP4 was associated with a higher frequency of CHC individuals consuming PUFA ≥ 4.9% (p = 0.004) and low viral load (p = 0.036), but a lower frequency of CHC individuals consuming fiber ≥ 21.5 g/d (p = 0.038). In SC and CHC individuals, modifying unhealthy DPs and targeting HCV-interacting nutrients, respectively, could be part of a nutritional management strategy to prevent further liver damage.

show abstract

“…Mexico launched the "Plan Nacional para la Eliminación de la Hepatitis C" in mid-2020, and screening campaigns, micro-elimination, and access to treatment in risk groups are now underway [25,26]. However, HBV elimination strategies are lagging [27]. The absence of a comprehensive surveillance system, a fragmented healthcare system, and a scarcity of research all contribute to this predicament [23].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus Genotype H: Epidemiological, Molecular, and Clinical Characteristics in Mexico

Panduro,

Roman,

Laguna-Meraz

et al. 2023

Viruses

Self Cite

View full text Add to dashboard Cite

The hepatitis B virus (HBV), comprising of ten genotypes (A-J), has been a silent threat against humanity, constituting a public health problem worldwide. In 2016, the World Health Organization set forth an impressive initiative for the global elimination of viral hepatitis by 2030. As the target date approaches, many nations, particularly in the Latin American region, face challenges in designing and implementing their respective elimination plan. This review aimed to portray the state of knowledge about the epidemiological, molecular, and clinical characteristics of HBV genotype H (HBV/H), endemic to Mexico. PubMed, Scopus, Web of Science, and Google Scholar were searched to compile scientific literature over 50 years (1970–2022). A total of 91 articles were organized into thematic categories, addressing essential aspects such as epidemiological data, risk factors, HBV genotype distribution, HBV mixed infections, clinical characteristics, and vaccination. The prevalence and its associated 95% confidence interval (95% CI) were estimated using the Metafor package in R programming language (version 4.1.2). We provide insights into the strengths and weaknesses in diagnostics and prevention measures that explain the current epidemiological profile of HBV/H. Training, research, and awareness actions are required to control HBV infections in Mexico. These actions should contribute to creating more specific clinical practice guides according to the region’s characteristics. Mexico’s elimination plan for HBV will require teamwork among the government health administration, researchers, physicians, specialists, and civil society advocates to overcome this task jointly.

show abstract

How far is Mexico from Viral Hepatitis Global Health Sector Strategy 2030 targets

Cited by 8 publications

References 16 publications

Donated Blood Screening for HIV, HCV and HBV by ID-NAT and the Residual Risk of Iatrogenic Transmission in a Tertiary Care Hospital Blood Bank in Puebla, Mexico

Donated Blood Screening for HIV, HCV and HBV by ID-NAT and the Residual Risk of Iatrogenic Transmission in a Tertiary Care Hospital Blood Bank in Puebla, Mexico

Adherence to a Fish-Rich Dietary Pattern Is Associated with Chronic Hepatitis C Patients Showing Low Viral Load: Implications for Nutritional Management

Hepatitis B Virus Genotype H: Epidemiological, Molecular, and Clinical Characteristics in Mexico

Contact Info

Product

Resources

About