Advancement of nanoscience in development of conjugated drugs for enhanced disease prevention

RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges

“…To further enhance the capability of drug delivery at targeted sites, many ligands conjugating with lipid-based nanoparticles have also been employed, including small compounds, carbohydrates, peptides, proteins, and antibodies. 182 , 183 For example, Sato et al. used vitamin A-conjugated liposomes to deliver siRNA against heat-shock protein 47 ( HSP47 ) for reversing human liver cirrhosis.…”

Smart dental materials for antimicrobial applications

“…pH-responsive nanocarriers such as nanogels, micelles, polymer-drug conjugates, core–shell NPs, and nanospheres have been used as vehicles for these types of biomaterials [ 182 ]. Generally, these compounds are fabricated with pH degradable linkages, pH cleavable crosslinking, or the inclusion of charge-shifting polymers that, when activated with the stimuli, release their payload to the environment [ 183 ] ( Fig. 3 ).…”

Recent trends in macromolecule-conjugated hybrid quantum dots for cancer theranostic applications

“…A recent study has reported on applying polysaccharide nano systems in treating cardiovascular disease, comprising heparin, chitosan, and numerous other substances. 102 These polysaccharides can act in various ways, including cell signaling and adhesion, by attaching to the proper proteins and sending a message that could affect the proteins biological processes. 103 In other cases, the binding proteins may chemically mimic the system to run the entire process naturally.…”