Advancement in separation materials for blood purification therapy

Ju, Jia; Liang, Feixue; Zhang, Xiaoxin; Sun, Ran; Pan, Xiaoguang; Xiao-yun, Guan; Cui, Guanning; He, Xuan; Li, Mengyan

doi:10.1016/j.cjche.2019.01.022

Cited by 16 publications

(4 citation statements)

References 83 publications

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“…In patients with liver diseases, due to leakage of bilirubin glucuronides from hepatocytes, reverse transfer from hepatocyte to plasma, or return from bile, the produced bilirubin is not destroyed in time and accumulates in the serum (Hansen, 2002;Blau et al, 2014). As a result, the body's toxic substances such as bilirubin and bile acids increase sharply in a short period of time, which seriously threatens the patient's life (Ju et al, 2019). Hence, detoxification through blood purification therapy is needed, which helps the recovery of organs (Rochon et al, 2011;Das, 2020).…”

Section: Design and Development Of Fe 3 O 4 @Prussian Bluementioning

confidence: 99%

Design and Development of Fe3O4@Prussian Blue Nanocomposite: Potential Application in the Detoxification of Bilirubin

Ali Hadi,

Hameid Odda,

Fadhil Jawad

et al. 2023

Asian Pac J Cancer Prev

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Background: Prussian blue nanoparticles (PBNPs) due to their high solubility, stability, flexible molecular structure, tunable size, easy synthesis, and surface modification have attracted the attention of researchers as high-efficiency therapeutic agents. Recently, it has been reported that magnetic nanoparticles can be to bind pathogenic substances on their surface, followed by a recollection by magnetic separation. Considering the potential application of PB and magnetic nanoparticles, in the current study we aimed to strategically design and synthesize a highly efficient nano-magnetic bilirubin scavenger system based on iron oxides@prussian blue nanocomposites (Fe 3 O 4 @PB) NCs. Materials and Methods: The Fe 3 O 4 @PB NCs were synthesized by an improved shell-growing procedure and identified using advanced characteristic techniques TEM, SEM, XRD, DLS, and Zeta potential. Synthesized Fe 3 O 4 @PB NCs showed good magneton properties and also demonstrated dramatic absorbent properties that empower use as an eco-friendly adsorbent nano agent for the detoxification of toxins. In addition, Fe 3 O 4 @PB nanoparticles showed high performance of bilirubin absorption in the serum and blood of sickle cell anemia patients. (Temp. 37.7ºC, the dose of adsorbent: 1 mg/mL, incubation time 30 min, and initial concentration: 0.25 mg/mL). Results: The results demonstrated an ideal adsorption capacity (86%) of Fe 3 O 4 @PB NCs which is significant compared to the reported adsorbents agents. These results pave the way for the application of Fe 3 O 4 @PB NCs for the effective purification of toxins from patients’ body fluids.

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Section: Design and Development Of Fe 3 O 4 @Prussian Bluementioning

confidence: 99%

Design and Development of Fe3O4@Prussian Blue Nanocomposite: Potential Application in the Detoxification of Bilirubin

Ali Hadi,

Hameid Odda,

Fadhil Jawad

et al. 2023

Asian Pac J Cancer Prev

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“…11,12 Unfortunately, chronic kidney failure has become an increasingly severe and prevalent issue, with advanced stages leading to uremia. 13,14…”

Section: Dialysis Membranes (Artificial Kidney)mentioning

confidence: 99%

“…11,12 Unfortunately, chronic kidney failure has become an increasingly severe and prevalent issue, with advanced stages leading to uremia. 13,14 Currently, dialysis membranes are the most widely used and effective treatment for kidney failure by removing uremic toxins in vitro. For decades, the aim of creating dialysis membranes that mimic the transport characteristics of the native kidney has driven progress in this field.…”

Section: Dialysis Membranes (Artificial Kidney)mentioning

confidence: 99%

The separation membranes in artificial organs

Sheng

Sun

et al. 2023

Mater. Chem. Front.

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“…The commonly used adsorbents are activated carbon (AC) and resin which includes ion-exchangers, high surface area adsorbents, etc. ( Chen et al, 2017a ; Ju et al, 2019 ; Yamamoto et al, 2019 ; Liu and Peng, 2021 ). However, these existing adsorbents was found to have limited unspecific absorptive capacity and poor biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Multi-Functional Hypercrosslinked Polystyrene as High-Performance Adsorbents for Artificial Liver Blood Purification

Liu

Peng

2022

Front. Chem.

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In artificial liver blood purification system, highly efficient removal of multiple toxic metabolites from whole blood by hemoperfusion still remains a challenge in the clinical field, due to the limited unspecific absorptive capacity and low biocompatibility of adsorbents. In this work, a new pyridinyl-modified hypercrosslinked polystyrene (HCP) adsorbent, named HCP(St-DVB-VP), was constructed directly through a Friedel-Crafts post-crosslinking reaction using a small-molecule crosslinking agent for the first time. The preparation method provides in this study can avert the problem posed by the use of the toxic carcinogenic chloromethyl ether reagent in the traditional HCP resin synthesis process. The results indicated that HCP(St-DVB-VP) had a highly porous structure with a specific surface area of 761 m2 g−1. Notably, the adsorbent demonstrated excellent adsorptive properties towards both protein-bound toxins (bilirubin) and medium- and large-sized molecular toxins (PTH, IL-6) in vitro experiments simultaneously. More importantly, the obtained adsorbent showed acceptable hemocompatibility. Taken together, the low-cost and ecofriendly fabrication method, broad-spectrum adsorption performance and hemocompatibility makes the HCP(St-DVB-VP) promising for whole blood perfusion in artificial liver blood purification in clinical practice.

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Advancement in separation materials for blood purification therapy

Cited by 16 publications

References 83 publications

Design and Development of Fe3O4@Prussian Blue Nanocomposite: Potential Application in the Detoxification of Bilirubin

Design and Development of Fe3O4@Prussian Blue Nanocomposite: Potential Application in the Detoxification of Bilirubin

The separation membranes in artificial organs

Multi-Functional Hypercrosslinked Polystyrene as High-Performance Adsorbents for Artificial Liver Blood Purification

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