Advanced-stage tongue and mouth floor cancer is related to tobacco and alcohol abuse

Bezerra, Natanael Victor Furtunato; Leite, Karla Lorene de França; Medeiros, Mariana Marinho Davino de; Martins, Mariana Leonel; Cardoso, Andreia Medeiros Rodrigues; Nonaka, Cassiano Francisco Weege; Padilha, Wílton Wilney Nascimento; Cavalcanti, Yuri Wanderley

doi:10.1007/s10389-017-0859-3

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Individuals diagnosed with oral cancer who did not present any deleterious habits and those who declared themselves only alcoholics were parameters of comparison in the present study. Alcoholics were put together to individuals with no deleterious habits because the literature reported that alcoholism alone is not associated with advanced stage of oral cancer ( 13 , 18 ). For individuals who have never been exposed to deleterious habits of alcoholism and smoking, the development of cancer can be attributed to other carcinogenic factors such as nutrition, viruses, immunosuppression and genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

Bezerra¹,

Leite²,

Medeiros³

et al. 2018

Med Oral

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BackgroundTo evaluate the prevalence of oral cancer in Brazil according to the clinical stage, anatomical location, alcoholism and smoking.Material and MethodsData referring to 31,217 cases of oral cancer, from 2000 to 2010, were obtained from the Integrator Module of the Hospital Registry of Cancer. Inconsistent data (“non-classified” cases) was eliminated and 21,160 cases were analyzed. The frequency distribution according to clinical stage, anatomical location, alcoholism and smoking was analyzed descriptively and through a binary logistic regression model (α<0.05). The clinical stage (dependent variable) was dichotomized in early stage (I and II) or advanced stage (III and IV). The year of diagnosis, anatomical location and deleterious habits (alcoholism and smoking) were considered independent variables.ResultsThe most frequent characteristics were: oropharynx location (n=3856, 18.41%), clinical stage IV (n=11924, 56.09%) and combined use of alcohol and tobacco (n=19226; 61.59%). The year 2009 (p<0.01, PR = 1.162, CI-95%=1.053-1.283) and location at the base of tongue (p<0.01, PR = 2.485, CI-95% = 2.182-2.807) presented a higher prevalence ratio for advanced stage oral cancer. The combined use of alcohol and tobacco showed a higher prevalence rate for the advanced clinical stage of cancer (p<0.01, PR =1.449, CI-95%=1.382-1.520) if compared to individuals without habits, or just alcoholics.ConclusionsHigher prevalence of advanced stage of oral cancer is related to the localization at the base of the tongue and to the concomitant use of alcohol and tobacco. Therefore, it can be suggested that all these characteristics lead to a worse prognosis of oral cancer. Key words:Oral cancer, neoplasm staging, alcoholism, tobacco use disorder.

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Section: Discussionmentioning

confidence: 99%

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

Bezerra¹,

Leite²,

Medeiros³

et al. 2018

Med Oral

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show abstract

“…Smoking and alcoholism are considered the main risk factors for oral cancer [ 4 , 5 ]. Other aspects such as human papillomavirus infection, solar radiation and genetics are also part of its complex etiology [ 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Public Oral Health Services and Socioeconomic Indicators on the Frequency of Hospitalization and Deaths due to Oral Cancer in Brazil, between 2002–2017

Freire

Araújo

et al. 2020

IJERPH

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Background: Oral cancer is a frequent neoplasm worldwide, and socioeconomic factors and access to health services may be associated with its risk. Aim: To analyze effect of socioeconomic variables and the influence of public oral health services availability on the frequency of new hospitalized cases and mortality of oral cancer in Brazil. Materials and Methods: This observational study analyzed all Brazilian cities with at least one hospitalized case of oral cancer in the National Cancer Institute database (2002–2017). For each city were collected: population size, Municipal Human Development Index (MHDI), Gini Coefficient, oral health coverage in primary care, number of Dental Specialized Centers (DSC) and absolute frequency of deaths after one year of the first treatment. The risk ratio was determined by COX regression, and the effect of the predictor variables on the incidence of cases was verified by the Hazard Ratio measure. Poisson regression was used to determine factors associated with higher mortality frequency. Results: Cities above 50,000 inhabitants, with high or very high MHDI, more unequal (Gini > 0.4), with less oral health coverage in primary care (<50%) and without DSC had a greater accumulated risk of having 1 or more cases (p < 0.001). Higher frequency of deaths was also associated with higher population size, higher MHDI, higher Gini and lower oral health coverage in primary care (p < 0.001). Conclusions: The number hospitalization and deaths due to oral cancer in Brazil was influenced by the cities’ population size, the population’s socioeconomic status and the availability of public dental services.

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“…The most marked trend in reduction of late-stage presentation was noted in floor of mouth when compared to anterior tongue and other oral sites, which showed little evidence of reduction over time. The observation regarding floor of mouth may be attributable to reduction in smoking and alcohol abuse, as it is believed that there is a relationship between these factors and advanced-stage tongue and floor of mouth cancer 35 .…”

Section: Different Oral Sitesmentioning

confidence: 99%

The impact of the UK ‘two-week rule’ on stage-on-diagnosis of oral cancer and the relationship to socio-economic inequalities

Langton

Lowe

Rogers

et al. 2019

Journal of Cancer Policy

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Advanced-stage tongue and mouth floor cancer is related to tobacco and alcohol abuse

Cited by 6 publications

References 24 publications

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

Impact of the anatomical location, alcoholism and smoking on the prevalence of advanced oral cancer in Brazil

Influence of Public Oral Health Services and Socioeconomic Indicators on the Frequency of Hospitalization and Deaths due to Oral Cancer in Brazil, between 2002–2017

The impact of the UK ‘two-week rule’ on stage-on-diagnosis of oral cancer and the relationship to socio-economic inequalities

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