Advanced Routes in Synthesis and Reactions of Lawsone Molecules (2‐Hydroxynaphthalene‐1,4‐dione)

Abstract

Lawsone (2‐hydroxynaphthalene‐1,4‐dione ) is a natural product which shows significant biological activity. Lawsone has been found as a component of many dyes as well as a constituent of medicinal herbal treatments. So, this review aimed to document the publications concerning the synthesis and chemical reactivity and reactions of lawsone reported by research groups.

Synthesis, DFT Studies, Antioxidant and Anticancer Activities of Newly Synthesized Compounds Containing Lawsone Using Different Halo Reagents.

“…2-hydroxynaphthalene-1,4-dione (Lawsone) (1) was prepared according to published literature method. 20,27,28 Biological activities were accomplished at the Hygia Institute of Pharmaceutical Education and Research Lucknow, Uttar Pradesh, India.…”

“…19 Based on the aforementioned biological activity and in continuation of the research on literature. 20,21 we described herein to synthesis annulated naphtha [b]furan trione compounds containing Lawsone moiety by using chloro and aldehyde reagents, respectively, and investigate their antioxidant and antitumor activities.…”

A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions

“…Moreover, it has been used as the starting material for the synthesis of a variety of biologically active compounds and materials with interesting properties. [28][29][30][31] This review highlights the synthesis of benzo[a]phenazin-5-ol derivatives from lawsone and benzene-1,2-diamines and their applications for the construction of a variety of ve and six membered fused heterocycles.…”