Phenazine systems are an important class of aza-polycyclic compounds that are easily found in nature and isolated as secondary metabolites primarily from Pseudomonas, Streptomyces, and a few other genera from soil or marine habitats.
A new series of bis‐heteroarylaminomethylnaphthoquinone Mannich bases have been synthesized through facial and efficient one‐pot pseudo five‐component reactions of lawsone, different heteroaryl amines and terephthaldehyde using p‐TSA as catalyst in CH3CN under reflux conditions. The high yields of products, very simple operation, readily available starting materials, high atom‐economy, easy workup procedure and isolation/purification of target products without chromatography are the main benefits of this synthetic strategy.
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A clean and efficient one-pot protocol for the synthesis of a series of new 2-hydroxy-3-((3-aryl)(heteroarylamino)methyl)naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and heterocyclic amines at 90 oC under solvent and catalyst-free conditions. The procedure avoids the use of toxic solvents, tedious work-up, catalyst and purification of the products by chromatographic methods. Simple operation, short reaction times, generating the desired compounds in high to excellent yields and an environmentally benign method are advantages of this protocol.
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