Advanced research on acteoside for chemistry and bioactivities

He, Jiang; Hu, Xiaopeng; Zeng, Yong; Li, Yan; Wu, Haiqiang; Qiu, Rong-Zhu; Ma, Wenjie; Li, Tao; Li, Chen-Yang; He, Zhendan

doi:10.1080/10286020.2011.568940

Cited by 84 publications

(72 citation statements)

References 104 publications

(25 reference statements)

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“…5), which has been investigated extensively and has shown various biological activities, including antioxidant, anti-inflammatory, skin-whitening, hepatoprotect and cell apoptosis regulation (He et al, 2011). The anti-inflammatory effect is due to the significant inhibition of arachidonic acid release (Lee et al, 2006).…”

Section: Rehmannia Glutinosamentioning

confidence: 99%

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Fong

Tong

et al. 2015

Journal of Ethnopharmacology

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Section: Rehmannia Glutinosamentioning

confidence: 99%

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Fong

Tong

et al. 2015

Journal of Ethnopharmacology

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“…The plant is described as a welltolerated plant material commonly used to treat upper respiratory symptoms. As acteoside has a wide range of pharmacological activities (He et al, 2011), it can contribute to general health as well.…”

Section: Introductionmentioning

confidence: 99%

Filamentous fungi from Plantago lanceolata L. leaves: Contribution to the pattern and stability of bioactive metabolites

et al. 2013

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The aim of this study was to test contribution of plant-associated microorganism (PAMs) to metabolite stability/instability in a medicinal plant matrix.Therefore, PAM strains were isolated and identified based on relevant DNA sequences from Plantago lanceolata leaves. Sterile water extracts of P. lanceolata were incubated with the isolated strains and antioxidants (ascorbic acid (AA), and EDTA) for 15 days, and changes in the concentrations of chief bioactive constituents (aucubin, catalpol, acteoside (= verbascoside)) were quantified by capillary electrophoresis. Phenolic breakdown-products were identified by GC-MS.PAMs were identified from the genera Epicoccum, Bipolaris, Cladosporium, Leptosphaerulina, Aspergillus, Eurotium and Penicillium (pathongens, endophytes, and other species). Some fungi caused significant decomposition of the chief constituents (p < 0.001). Surprisingly, some strains inhibited breakdown of acteoside (p < 0.001). Meanwhile, concentration of several phenolic acids increased in fungi-infested extracts (p<0.001). Gentisic acid, 4-hydroxyphenyl acetic acid, 4-hydroxybenzoic acid and hydroxytyrosol were only present when the extract was infested with a PAM. The products are powerful antioxidants and chelators. Concentrations of phenolic acids influenced acteoside stability significantly (p < 0.01), as shown by basic data-mining techniques. AA and EDTA also significantly inhibited acteoside breakdown in sterile model solutions (p < 0.05).Our results suggest, that the phenolic acid mixture (produced during the fungal proliferation) protected acteoside from breakdown, possibly via its antioxidant activity and metal complexing ability.It was shown, that PAMs can increase or decrease the stability of chief metabolites in herbal matrices, and can significantly alter the chemical pattern of the plant matrix. 2 KeywordsPlantago lanceolata L., ribwort plantain, endophyte, plant-associated microorganism, metabolite stability, phenolic acids, acteoside 3

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“…It has been reported that acteoside has extensive biological activities including antioxidant (Chiou et al 2004;He et al 2000), anti-inflammatory (Lee et al 2005(Lee et al , 2006, hepatoprotective (Xiong et al 1999;Zhao et al 2009), cell apoptosis regulation activities (Ohno et al 2002;Xiong et al 1999;Yang and Pu 2006) and cytotoxicity against various tumor cells (Kunvari et al 1999;Lee et al 2007). It may be developed into a promising medication (He et al 2011). Acteoside is generally contained only at low amount in plants (Imakura et al 1985;Kitagawa et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Establishment of callus and cell suspension culture of Scrophularia striata Boiss.: an in vitro approach for acteoside production

2014

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In the present study, a protocol was optimized for establishment of callus and cell suspension culture of Scrophularia striata Boiss. as a strategy to obtain an in vitro acteoside producing cell line for the first time. The effects of growth regulators were analyzed to optimize the biomass growth and acteoside production. The stem explant of S. striata was optimum for callus induction. Modified Murashige and Skoog medium supplemented with 0.5 mg/l naphthalene acetic acid ? 2.0 mg/l benzyl adenine was the most favorable medium for callus formation with the highest induction rate (100 %), the best callus growth and the highest acteoside content (1.6 lg/g fresh weight). Incompact and rapid growing suspension cells were established in the liquid medium supplemented with 0.5 mg/l naphthalene acetic acid ? 2.0 mg/l benzyl adenine. The optimum time of subculture was found to 17-20 days. Acteoside content in the cell suspension was high during exponential growth phase and decreased subsequently at the stationary phase. The maximum content of acteoside (about 14.25 lg/g cell fresh weight) was observed on the 17th day of the cultivation cycle. This study provided an efficient way to further regulation of phenylethanoid glycoside biosynthesis and production of valuable acteoside, a phenylethanoid glycoside, on scale-up in S. striata cell suspension culture.

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Advanced research on acteoside for chemistry and bioactivities

Abstract: Acteoside is one kind of phenylethanoid glycoside, which has shown a lot of biological activities. This article reviewed the study progress of acteoside, such as distribution, preparation, identification, and bioactivities.

Cited by 84 publications

References 104 publications

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

Filamentous fungi from Plantago lanceolata L. leaves: Contribution to the pattern and stability of bioactive metabolites

Establishment of callus and cell suspension culture of Scrophularia striata Boiss.: an in vitro approach for acteoside production

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