Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia

Wang, Shi-Heng; Hsiao, Po-Chang; Yeh, Ling‐Ling; Liu, Chih-Min; Liu, Chen-Chung; Hwang, Tzung‐Jeng; Hsieh, Ming H.; Chien, Yi‐Ling; Lin, Yuanqing; Huang, Yen‐Tsung; Chen, Chia‐Yen; Chandler, Sharon D.; Faraone, Stephen V.; Neale, Benjamin M.; Glatt, Stephen J.; Tsuang, Ming T.; Hwu, Hai‐Gwo; Chen, Wei-Jen

doi:10.1016/j.biopsych.2019.01.023

Cited by 19 publications

(9 citation statements)

References 43 publications

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“…There is a moderate certainty of evidence [91] of increased risk of schizophrenia with increasing paternal age [89], starting at a paternal age as early as 25 years [40], including four meta-analyses [83,91,115,124]. Wang et al found that paternal age has an independent role in early onset of schizophrenia in offspring [122]. There is a weak evidence for association between paternal age and bipolar disorders [89], although findings have been inconclusive.…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.

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Section: Psychiatric Disordersmentioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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“…There is preliminary evidence to suggest that advanced paternal age may increase the occurrence of adverse pregnancy outcomes such as miscarriage (5), stillbirth (6) or preterm birth (7). The adverse offspring outcomes include higher rates of congenital malformations (8), malignancies (9), early onset schizophrenia (10), autism (11) and other psychiatry or academic morbidities (12).…”

Section: Introductionmentioning

confidence: 99%

Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

et al. 2021

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PurposeWhile it is well documented that maternal adverse exposures contribute to a series defects on offspring health according to the Developmental Origins of Health and Disease (DOHaD) theory, paternal evidence is still insufficient. Advanced paternal age is associated with multiple metabolism and psychiatric disorders. Birth weight is the most direct marker to evaluate fetal growth. Therefore, we designed this study to explore the association between paternal age and birth weight among infants born at term and preterm (<37 weeks gestation).MethodsA large retrospective study was conducted using population-based hospital data from January 2015 to December 2019 that included 69,964 cases of singleton infant births with complete paternal age data. The primary outcome was infant birth weight stratified by sex and gestational age including small for gestational age (SGA, 10th percentile) and large for gestational age (LGA, 90th percentile). Birth weight percentiles by gestational age were based on those published in the INTERGROWTH-21st neonatal weight-for gestational-age standard. Logistic regression analysis and linear regression model were used to estimate the association between paternal age and infant birth weight.ResultsAdvanced paternal age was associated with a higher risk for a preterm birth [35–44 years: adjusted odds ratio (OR) = 1.13, 95%CI (1.03 to 1.24); >44 years: OR = 1.36, 95%CI (1.09 to 1.70)]. Paternal age exerted an opposite effect on birth weight with an increased risk of SGA among preterm infants (35–44years: OR = 1.85, 95%CI (1.18 to 2.89) and a decreased risk among term infant (35–44years: OR = 0.81, 95%CI (0.68 to 0.98); >44 years: OR = 0.50, 95%CI (0.26 to 0.94). U-shaped associations were found in that LGA risk among term infants was higher in both younger (<25 years) (OR = 1.32; 95%CI, 1.07 to 1.62) and older (35–44 years) (OR = 1.07; 95% CI, 1.01 to 1.14) fathers in comparison to those who were 25 to 34 years old at the time of delivery.ConclusionsOur study found advanced paternal age increased the risk of SGA among preterm infants and for LGA among term infants. These findings likely reflect a pathophysiology etiology and have important preconception care implications and suggest the need for antenatal monitoring.

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“…Advanced paternal age has also been implicated in increased risk and earlier onset of symptoms (Wang et al 2015;Fond et al 2017). A recent study supported an independent role of both advanced paternal age and of very young paternal age in increasing risk for early-onset schizophrenia in offspring (Wang et al 2019).…”

Section: Environmental and Paternal Risk Factorsmentioning

confidence: 92%

Genetic Risk Assessment in Psychiatry

Peay

2019

Cold Spring Harb Perspect Med

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Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia

Cited by 19 publications

References 43 publications

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

Genetic Risk Assessment in Psychiatry

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