Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization

Arrigo, Alessandro; Aragona, Emanuela; Capone, Luigi; Pierro, Luisa; Romanò, Francesco; Bandello, Francesco; Parodi, Maurizio Battaglia

doi:10.1016/j.ajo.2018.08.001

Cited by 33 publications

(29 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar studies have shown that both SCP-VD and DCP-VD values are significantly associated with age. 24 , 25 Like Bazvand et al 26 , we observed that RPCP-VD was not affected by age or sex. In contrast to the study by Yu et al 27 , we did not detect any relationship between RPCP-VD and RNFLT.…”

Section: Discussionsupporting

confidence: 75%

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

İçel¹,

Yılmaz²,

Uçak³

et al. 2020

tjo

View full text Add to dashboard Cite

Objectives: To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL). Materials and Methods: A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the OCTA device, foveal avascular zone (FAZ) area, vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, and the VD of the radial peripapillary capillary plexus (RPCP) of the optic disc were recorded. Results: The mean age of the study group was 11.27±3 years, the mean AL was 23.39±1.18 mm and the mean SE was -1.31±1.61 diopters. The mean FAZ area was 0.3±0.09 mm 2 , the mean SCP-VD was 43.88±3.4%, the mean DCP-VD was 39.6±3.55%, and the mean RPCP-VD was 52.47±3.42%. When the relationship between the OCTA measurements and the SE and AL values were analyzed, there was no statistical significance (p>0.05). When age and OCTA measurements were compared, only DCP-VD values were found to significantly decrease with increasing age (p=0.015). There was no significant difference in OCTA measurements based on gender (p>0.05). Similarly, no statistical age-based differences were observed in RNFLT, CMV and CMT values (p>0.05). Conclusion: With its short procedure time and no dye requirement, OCTA can be safely used in the evaluation of the optic disc and macular perfusion in children. Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.

show abstract

Section: Discussionsupporting

confidence: 75%

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

İçel¹,

Yılmaz²,

Uçak³

et al. 2020

tjo

View full text Add to dashboard Cite

show abstract

“…This phenomenon was not observed for vessel density and may explain the lack of vessel tortuosity correlations with RNFL and visual field impairments. Taking into consideration the overall distribution of optic disc swelling in all the quadrants, based on our data and on previous findings [12,13], vessel tortuosity might be considered a more sensitive parameter for the quantification of blood flow impairment occurring in AAION and NAION. Also, in the sub-analysis, AAION showed worse vessel density and vessel tortuosity values than NAION.…”

Section: Discussionsupporting

confidence: 56%

“…The first was related to the possible artifacts affecting OCTA images [14]. With respect to VT parameter, this represents a novel quantitative parameter which may be interpreted as an indirect measure of the amount of perfusion [13,15]. Although it is based on the proper reconstruction of the vascular network, it is potentially artifact prone.…”

Section: Discussionmentioning

confidence: 99%

“…Although it is based on the proper reconstruction of the vascular network, it is potentially artifact prone. On the other hand, since we used only high quality images and the calculation of VT strictly depends on the geometrical properties of continuous linear signal retinal capillaries [13,15] with poor or null influence of spurious artifact signal, it may be considered a reliable quantitative measure of the perfusion features of the retinal vascular network. Moreover, although we selected only high-quality images, we cannot exclude the possible influence of optic disc swelling on the detection of blood flow signal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vessel Density and Vessel Tortuosity Quantitative Analysis of Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathies: An Optical Coherence Tomography Angiography Study

Pierro¹,

Arrigo²,

Aragona³

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

The aim of this study was to perform quantitative optical coherence tomography angiography (OCTA) assessment of arteritic and non-arteritic anterior ischemic optic neuropathies (AION; NAION). The study was designed as an observational, cross-sectional case series. All patients underwent complete ophthalmologic evaluation including LogMAR best-corrected visual acuity (BCVA), structural optical coherence tomography (OCT) and OCTA images, and dye-based angiography. Retinal nerve fiber layer (RNFL) thickness was obtained from structural OCT, and vessel density (VD) and vessel tortuosity (VT) were measured for each optic nerve head vascular plexus. After selecting the quadrants showing visual field defects, measured by Humphrey 30.2 perimetry (Zeiss Meditec, Dublin, CA, USA), we assessed the correlation between the localization of visual field defects and the quadrants showing impairments of RNFL, VD, and VT. Thirty naïve AION patients (15 arteritic AION (AAION) and 15 non-arteritic AION (NAION)) were included. LogMAR BCVA was 0.6 ± 0.2 for AAION and 0.3 ± 0.3 for NAION (p < 0.01). AAION and NAION eyes showed significant differences in terms of visual field involvement as well as VD and VT values, with remarkably worse alterations affecting AAION eyes. VD values perfectly matched with the quadrants showing RNFL and visual field defects. On the contrary, VT resulted remarkably decreased in all the quadrants, with even worse values in the quadrants showing RNFL and visual field alterations. The present study showed that AAION eyes are more injured than NAION ones. VD represents a good parameter for the detection of the main site on vascular impairment. Remarkably, VT resulted in a more sensitive parameter for the quantitative detection of blood flow impairment in AION disease.

show abstract

“…Distinct quantitative OCTA parameters were adopted in order to analyze the MNV characteristics, including vessel tortuosity (VT) and vessel dispersion (VDisp), which are already employed in assessing other pathological conditions. 15 – 18 In short, VT is defined as the ratio of the shortest pathway to the straight-line length 19 and provides information about vascular perfusion. 20 , 21 VDisp is defined as a measure of the space-filling of a given vascular tree 22 and provides information about the vascular network disorganization.…”

Section: Methodsmentioning

confidence: 99%

Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy

Parodi

Arrigo

Bandello

2020

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

To describe quantitative characteristics of macular neovascularization (MNV) in vitelliform macular dystrophy (VMD) patients by means of optical coherence tomography angiography (OCTA). METHODS. The study design was a prospective case series. All patients underwent complete ophthalmologic assessment, optical coherence tomography, and OCTA. The quantitative OCTA parameters examined included vessel tortuosity and vessel dispersion of the MNV. The primary outcome was OCTA characterization of MNV in VMD. Secondary outcomes included the evolution of MNV over the follow-up. RESULTS. A total of 78 eyes were recruited for the study. MNV was identified in 50 eyes (64%) at baseline and in 51 eyes (65%) at the end of the follow-up (mean follow-up, 24.7 ± 9.7 months). MNV was detected in four out of the 30 eyes classified as stages 2 and 3 (13%), showing exudative manifestations and undergoing ranibizumab treatment, leading to clinical stabilization. OCTA detected MNV in 46 out of 48 eyes (96%) classified as stages 4 and 5, showing no evidence of exudative manifestation. All of the non-exudative MNVs were merely observed over the follow-up and received no treatment. At the end of the follow-up, 47 out of 48 eyes displayed MNV (98%). Non-exudative MNVs remained stable over the follow-up. Statistically significant differences were found when comparing vessel tortuosity and vessel dispersion in the two MNV subforms. CONCLUSIONS. VMD is characterized by two MNV subforms. Exudative MNV is rare and may develop in the early stages of the disease, in association with bleeding and fluid formation. Non-exudative MNV develops very commonly in the advanced stage of VMD, without any exudative manifestation.

show abstract

Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization

Cited by 33 publications

References 31 publications

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography

Vessel Density and Vessel Tortuosity Quantitative Analysis of Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathies: An Optical Coherence Tomography Angiography Study

Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy

Contact Info

Product

Resources

About