Advanced “lab-on-a-chip” to detect viruses – Current challenges and future perspectives

Zhuang, Jianjian; Yin, Juxin; Lv, Shaowu; Wang, Ben; Mu, Ying

doi:10.1016/j.bios.2020.112291

Cited by 112 publications

(91 citation statements)

References 187 publications

(208 reference statements)

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“…This enrichment method, coupled with Raman techniques, constitutes an innovative system that could be used to quickly track and monitor viral outbreaks in real-time [123]. Furthermore, Zhuang et al reviewed different point-of-care techniques in the assistance of analytical chemistry with the emphasis on SERS-based technologies and represents that by using different polymer-based membranes in the microfluidic devices, these nanosystems can be easily optimized to detect different types of viruses [124].…”

Section: Point-of-care Detection Of Sars-cov-2mentioning

confidence: 99%

Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic

Rabiee

Bagherzadeh

Ghasemi

et al. 2020

IJMS

111

100

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover, promising research ideas for high accuracy of detection in trace concentrations, via color change and light-sensitive nanostructures, to assist fingerprint techniques (to identify the virus at the contact surface of the gas and solid phase) are also presented.

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Section: Point-of-care Detection Of Sars-cov-2mentioning

confidence: 99%

Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic

Rabiee

Bagherzadeh

Ghasemi

et al. 2020

IJMS

111

100

View full text Add to dashboard Cite

show abstract

“…Microfluidic devices (e.g., lab-on-a-chip and μ-TAS) are attractive solutions when rapid 'point-of-care' (POC) testing with minimal consumption of the sample is required, such as in biological and chemical applications, medical diagnostics, food safety management, environmental monitoring, epidemics, and viral infections. [1][2][3][4][5][6][7] Therefore, to expedite the use of microfluidic devices, it is important to enable faster and more precise analysis and simple high-throughput systems by developing various fluid-control microfluidic platforms for sample weighing, reagent separation, mixing, reactions, and so on. 8 In particular, mixing elements such as micromixers are key aspects of microfluidic devices that are used in pre-treatment steps in biochemical analysis, drug delivery, sequencing, and synthesis.…”

Section: Introductionmentioning

confidence: 99%

Monolithic 3D micromixer with an impeller for glass microfluidic systems

Kim

Joung

et al. 2020

Lab Chip

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“…Array-based detection strategies typically rely on a single type of capture probe for all analytes [ 1 ]. For example, arrays designed to detect and quantify proteins in a sample may consist entirely of antibodies specific for each target, while those intended to assay nucleic acids may consist entirely of target-specific DNA probes.…”

Section: Introductionmentioning

confidence: 99%

A Stable Biotin-Streptavidin Surface Enables Multiplex, Label-Free Protein Detection by Aptamer and Aptamer-Protein Arrays Using Arrayed Imaging Reflectometry

Klose

Miller

2020

Sensors

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While label-free multiplex sensor technology enables “mixing and matching” of different capture molecules in principle, in practice this has been rarely (if ever) demonstrated. To fill this gap, we developed protocols for the preparation of mixed aptamer-protein arrays on the arrayed imaging reflectometry (AIR) sensing platform using streptavidin as a common attachment point for both biotinylated proteins and aptamers. Doing so required overcoming the noted instability of dried streptavidin monolayers on surfaces. After characterizing this degradation, stable surfaces were obtained using a commercial microarray product. Microarraying through the layer of stabilizer then provided mixed aptamer-antibody arrays. We demonstrate that sensor arrays prepared in this manner are suitable for several probes (thrombin and TGF-β1 aptamers; avi-tagged protein) and targets.

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Advanced “lab-on-a-chip” to detect viruses – Current challenges and future perspectives

Cited by 112 publications

References 187 publications

Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic

Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic

Monolithic 3D micromixer with an impeller for glass microfluidic systems

A Stable Biotin-Streptavidin Surface Enables Multiplex, Label-Free Protein Detection by Aptamer and Aptamer-Protein Arrays Using Arrayed Imaging Reflectometry

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