Monolithic 3D micromixer with an impeller for glass microfluidic systems

Kim, Sung-Il; Kim, Jeong-Tae; Joung, Yeun-Ho; Ahn, Sanghoon; Park, Changkyoo; Choi, Jiyeon; Koo, Chiwan

doi:10.1039/d0lc00823k

Cited by 26 publications

(15 citation statements)

References 59 publications

(80 reference statements)

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“…40 This design and related waterwheel-based systems have been integrated into smaller-scale pumps for use as an artificial heart pump 41 as well as in microfluidic technology. 27,28,30,[42][43][44] To adapt the centrifugal pump design to be compatible with recirculating fluid flow in a microfluidic device, spinning magnets were used to drive impeller rotation. Unlike rotating the impeller using an external motor, the use of a rotating magnetic field to drive fluid flow resulted in a simple set-up that was readily compatible with microfabrication techniques.…”

Section: Concept Of the Microscale Impeller Pumpmentioning

confidence: 99%

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

et al. 2022

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Section: Concept Of the Microscale Impeller Pumpmentioning

confidence: 99%

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

et al. 2022

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“…In addition, a heater slot was designed so that the chip resistor heater could be placed at the exact center of the PCR reaction chamber (Figure 4A). To fabricate cavity structures for the PCR chamber and the heater slot in the glass microchip, we performed a two-step process with laser direct writing and etching with the optimized SLE process conditions (Figure 4B) [30,31]. This technique allowed the fast and easy fabrication of a 3D cavity inside the glass.…”

Section: Methodsmentioning

confidence: 99%

“…This process allows the fabrication of a 3D hollow structure inside one single glass without a bonding process, making it useful for rapidly fabricating a prototype glass microchip [27][28][29]. Earlier, we reported an optimization method for fabricating 3D structures in a single glass sheet using the SLE process [30,31]. This study used the optimized SLE process conditions to fabricate a PCR reaction chamber and a chip resistor slot in the glass microchip.…”

Section: Introductionmentioning

confidence: 99%

A Thermocycler Using a Chip Resistor Heater and a Glass Microchip for a Portable and Rapid Microchip-Based PCR Device

Yeom

Kim

et al. 2022

Micromachines

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This study proposes a rapid and inexpensive thermocycler that enables rapid heating of samples using a thin glass chip and a cheap chip resistor to overcome the on-site diagnostic limitations of polymerase chain reaction (PCR). Microchip PCR devices have emerged to miniaturize conventional PCR systems and reduce operation time and cost. In general, PCR microchips require a thin-film heater fabricated through a semiconductor process, which is a complicated process, resulting in high costs. Therefore, this investigation substituted a general chip resistor for a thin-film heater. The proposed thermocycler consists of a compact glass microchip of 12.5 mm × 12.5 mm × 2 mm that could hold a 2 μL PCR sample and a surface-mounted chip resistor of 6432 size (6.4 mm × 3.2 mm). Improving heat transfer from the chip resistor heater to the PCR reaction chamber in the microchip was accomplished via the design and fabrication of a three-dimensional chip structure using selective laser-induced etching, a rapid prototyping technique that allowed to be embedded. The fabricated PCR microchip was combined with a thermistor temperature sensor, a blower fan, and a microcontroller. The assembled thermocycler could heat the sample at a maximum rate of 28.8 °C/s per second. When compared with a commercially available PCR apparatus running the same PCR protocol, the total PCR operating time with a DNA sample was reduced by about 20%.

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“…Noteworthily, the glass microfluidic system of monolithic 3D micromixer with impeller is proposed. 14 However, the impeller structure is complicated and the processing time is more than 24 h.…”

Section: Introductionmentioning

confidence: 99%

“…Despite all of these, the actual use process needs to adopt the matching rotating platform. Noteworthily, the glass microfluidic system of monolithic 3D micromixer with impeller is proposed . However, the impeller structure is complicated and the processing time is more than 24 h.…”

Section: Introductionmentioning

confidence: 99%

Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure

et al. 2021

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In this paper, a helical three-dimensional (3D) passive micromixer is presented. A three-dimensional spiral passive micromixer is fabricated through the 3D printing technology and the polymer dissolution technology. The main process is as follows: First of all, a high-impact polystyrene (HIPS) material was used to make a 3D spiral channel mold. Second, the channel mold was dissolved in limonene solvent. The mixing experiment shows that the single helix structure can improve the mixing efficiency to 0.85, compared with the mixing efficiency of 0.78 in the traditional T-shaped two-dimensional (2D)-plane channel. Different screw diameters, screw number structures, and flow rates are used to test the mixing effect. The optimal helical structure is 5 mm, and the flow rate is 2.0 mL/min. Finally, the mixing efficiency of the 3D helical micromixer can reach 0.948. The results show that the three-dimensional helical structure can effectively improve the mixing efficiency.

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Monolithic 3D micromixer with an impeller for glass microfluidic systems

Abstract: The performance of micromixers, namely their mixing efficiency and throughput, is a critical component in increasing the overall efficiency of microfluidic systems (e.g., lab-on-a-chip and µ-TAS). Most previously reported high-performance...

Cited by 26 publications

References 59 publications

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

A Thermocycler Using a Chip Resistor Heater and a Glass Microchip for a Portable and Rapid Microchip-Based PCR Device

Efficient Mixing of Microfluidic Chip with a Three-Dimensional Spiral Structure

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