“…Moreover, treatment with MGF significantly inhibited the increase in microglial number in the hippocampus, suggesting that the neuroprotective role of MGF might be associated with its inhibitory effect on microglial activation. To further elucidate the potential targets of MGF, we performed bioinformatics analysis and found that MGF targets MAPK signaling, which regulates cell proliferation, stress response, inflammation, cell differentiation, and apoptosis (Li Z et al, 2021;Qin et al, 2021;Wang et al, 2021;Yang et al, 2021). More importantly, the MAPK signal pathway has been linked to several diseases, including depression (Duman et al, 2007;Wang and Mao, 2019;Humo et al, 2020).…”