Advanced glycation end products, aortic stiffness, and wave reflection in peritoneal dialysis as compared to hemodialysis

Mac‐Way, Fabrice; Couture, Véronique; Utescu, Mihai Silviu; Ignace, Sophie; Serres, Sacha A. De; Loignon, Renée-Claude; Marquis, Karine; Lariviere, Richard W.; Agharazii, Mohsen

doi:10.1007/s11255-013-0597-6

Cited by 25 publications

(15 citation statements)

References 39 publications

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“…First, multiple risk factors in relation to ESRD, such as inflammation, endothelial dysfunction, atherosclerosis, vascular calcification and hyperhomocysteinemia [ 31 – 35 ], also play roles in the development and progression of CI. The accumulation of advanced glycosylation end products triggers vascular endothelial dysfunction, increases permeability of blood vessels and causes hardening [ 36 – 38 ]; by which the mechanisms correlate with CI in T2DM may react in ESRD patients under PD [ 39 – 41 ]. PD vintage of non-DM group was longer than DM group in our subject; this can be interpreted as the hypothesis that historical glucose exposure of non-DM group was not low.…”

Section: Discussionmentioning

confidence: 99%

An association of cognitive impairment with diabetes and retinopathy in end stage renal disease patients under peritoneal dialysis

et al. 2017

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BackgroundDiabetes and retinopathy have been considered as risk factors of cognitive impairment (CI) in previous studies. We investigated both of these two factors and their relationship with global and specific cognitive functions in end stage renal disease patients under peritoneal dialysis (PD).MethodsIn this multicenter cross-sectional study, 424 clinically stable patients were enrolled from 5 PD units, who performed PD for at least three months and completed fundoscopy examination if they had diabetes. Global cognitive function was measured using the Modified Mini-Mental State Examination (3MS), Trail-Making Test forms A and B for executive function, and subtests of the Battery for the Assessment of Neuropsychological Status for immediate and delayed memory, visuospatial skills, and language ability.ResultsPD Patients with DM and Retinopathy had significantly higher prevalence of CI, executive dysfunction, impaired immediate memory and visuospatial skill, compared with patients in non-DM group. By multivariate logistic regression analyses, DM and retinopathy rather than DM only were significantly associated with increased risk for CI, executive dysfunction, impaired immediate memory and visuospatial skill, odds ratios(ORs) and 95% confidence intervals were 2.09[1.11,3.92], 2.89[1.55,5.37], 2.16 [1.15,4.06] and 2.37[1.32,4.22], respectively (all P < 0.05).ConclusionsDiabetic PD patients with retinopathy were at two times risk for overall cognitive impairment, executive dysfunction, impaired immediate memory and visuospatial skill as compared to non-diabetic PD patients.

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Section: Discussionmentioning

confidence: 99%

An association of cognitive impairment with diabetes and retinopathy in end stage renal disease patients under peritoneal dialysis

et al. 2017

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“…On the other hand, some clinical studies have indicated the relation between skin AF or impairment of blood rheology and arterial stiffness using pulse wave velocity (PWV). Mac-Way et al reported that skin AF is signifi cantly related with carotidfemoral PWV [34]. Satoh et al reported the relation between WBPT and stiffness of the aortic artery using PWV in patients with obesity [9].…”

Section: Discussionmentioning

confidence: 99%

Relations between Skin Autofluorescence and Hemorheology Assessed by a Microchannel Method in Patients with Traditional Cardiovascular Risk Factors

Hatori¹

2017

Glob J Obes Diabetes Metab Syndr

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Aim: In recent years, skin autofl uorescence (AF), a marker of tissue accumulation of advanced glycation end products, and hemorheology assessed by a microchannel method have been noted for their signifi cance in detecting cardiovascular risk factors. However, there have been no reports regarding the relation between these two biomarkers. The present study attempts to clarify the relation and background factors of these two biomarkers in patients with traditional cardiovascular risk factors. Methods: A total of 807 outpatients with traditional cardiovascular risk factors (306 males and 501 females; mean age: 64 ± 11 years) and no history of cardiovascular events were enrolled in this study. Skin AF and whole blood passage time (WBPT) as a marker of hemorheology were measured using a commercial device, and the relations among various clinical parameters, including that between skin AF and WBPT, were examined. Results: There was a signifi cantly positive correlation between skin AF and WBPT (r = 0.41, p < 0.001). Furthermore, multiple regression analysis revealed that these two markers showed a signifi cant correlation (p < 0.01). Furthermore, derivatives of the reactive oxygen metabolites test, an oxidative stress marker, the cardio-ankle vascular index, an arterial function marker, smoking habits, and a number of traditional cardiovascular risk factors in an individual were also selected as independent variables for both skin AF and WBPT. Conclusion: The results of this study indicated the signifi cant relation between skin AF and hemorheology assessed by a microchannel method in patients with traditional cardiovascular risk factors. In addition, oxidative stress, arterial dysfunction, smoking habits, and a clustering of traditional cardiovascular risk factors were associated with these two biomarkers.

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“…In addition, some data support the hypothesis that AGEs contribute to cardiovascular disease. AGEs cross‐link with proteins of the extracellular matrix (eg, collagen and elastin), altering their structural and functional properties, which translates into increased arterial stiffness and endothelial dysfunction . AGEs also worsen vascular tissue damage by binding to specific AGE receptors (RAGEs) that induce oxidative stress and systemic inflammation …”

Section: Dialysis‐related Cardiovascular Risk Factorsmentioning

confidence: 99%

“…AGEs cross-link with proteins of the extracellular matrix (eg, collagen and elastin), altering their structural and functional properties, which translates into increased arterial stiffness and endothelial dysfunction. 53 AGEs also worsen vascular tissue damage by binding to specific AGE receptors (RAGEs) that induce oxidative stress and systemic inflammation. 54 Two separate meta-analyses and a Cochrane review have all concluded that dialysis fluids with lower GDP levels (so-called biocompatible fluids) preserve RRF as compared with standard dialysate, although there were some caveats regarding the quality of included studies.…”

Section: Pd-specific Factorsmentioning

confidence: 99%

Peritoneal dialysis has optimal intradialytic hemodynamics and preserves residual renal function: Why isn't it better than hemodialysis?

Selby

Kazmi

2018

Seminars in Dialysis

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Rates of cardiovascular mortality are disproportionately high in patients with end stage kidney disease receiving dialysis. However, it is now generally accepted that patient survival is broadly equivalent between the two most frequently used forms of dialysis, in‐center hemodialysis (HD) and peritoneal dialysis (PD). This equivalent patient survival is notable when considering how specific aspects of HD have been shown to contribute to morbidity and mortality. These include more rapid loss of residual renal function (RRF), HD‐induced myocardial and cerebral ischemia, and risk factors associated with the intermittent delivery of HD. Potential mechanisms specific to PD that may drive cardiovascular disease include the metabolic consequences of excessive absorption of glucose and glucose degradation products (GDPs), inadequate volume control, and high rates of hypokalemia. The aim of this review is to compare and contrast the different drivers of adverse outcomes between the dialysis modalities, as greater understanding of this may help in patient‐centered decision‐making when considering options for renal replacement therapy.

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Advanced glycation end products, aortic stiffness, and wave reflection in peritoneal dialysis as compared to hemodialysis

Abstract: Skin AF and aortic stiffness were higher in PD after adjustments for imbalances in baseline characteristics. Independent of dialysis modality, there was a positive association between skin AF, aortic stiffness, and enhanced wave reflection.

Cited by 25 publications

References 39 publications

An association of cognitive impairment with diabetes and retinopathy in end stage renal disease patients under peritoneal dialysis

An association of cognitive impairment with diabetes and retinopathy in end stage renal disease patients under peritoneal dialysis

Relations between Skin Autofluorescence and Hemorheology Assessed by a Microchannel Method in Patients with Traditional Cardiovascular Risk Factors

Peritoneal dialysis has optimal intradialytic hemodynamics and preserves residual renal function: Why isn't it better than hemodialysis?

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