Relations between Skin Autofluorescence and Hemorheology Assessed by a Microchannel Method in Patients with Traditional Cardiovascular Risk Factors

Abstract

Aim: In recent years, skin autofl uorescence (AF), a marker of tissue accumulation of advanced glycation end products, and hemorheology assessed by a microchannel method have been noted for their signifi cance in detecting cardiovascular risk factors. However, there have been no reports regarding the relation between these two biomarkers. The present study attempts to clarify the relation and background factors of these two biomarkers in patients with traditional cardiovascular risk factors. Methods: A total of 807 outpatients with traditional cardiovascular risk factors (306 males and 501 females; mean age: 64 ± 11 years) and no history of cardiovascular events were enrolled in this study. Skin AF and whole blood passage time (WBPT) as a marker of hemorheology were measured using a commercial device, and the relations among various clinical parameters, including that between skin AF and WBPT, were examined. Results: There was a signifi cantly positive correlation between skin AF and WBPT (r = 0.41, p < 0.001). Furthermore, multiple regression analysis revealed that these two markers showed a signifi cant correlation (p < 0.01). Furthermore, derivatives of the reactive oxygen metabolites test, an oxidative stress marker, the cardio-ankle vascular index, an arterial function marker, smoking habits, and a number of traditional cardiovascular risk factors in an individual were also selected as independent variables for both skin AF and WBPT. Conclusion: The results of this study indicated the signifi cant relation between skin AF and hemorheology assessed by a microchannel method in patients with traditional cardiovascular risk factors. In addition, oxidative stress, arterial dysfunction, smoking habits, and a clustering of traditional cardiovascular risk factors were associated with these two biomarkers.