Advanced glycation end products (AGEs) in oral pathology

Ilea, Aranka; Băbţan, Anida Maria; Boşca, Bianca Adina; Crışan, Maria; Petrescu, Nausica Bianca; Collino, Massimo; Sainz, Rosa M.; Gerlach, Jared Q.; Câmpian, Radu Septimiu

doi:10.1016/j.archoralbio.2018.05.013

Cited by 38 publications

(32 citation statements)

References 67 publications

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“…However, the mechanisms linking dietary AGEs exposure to their absorption and their effective bioavailability, are still largely unknown. Here we recorded an important local accumulation of AGEs and overexpression of RAGE not only in the ileum tract of intestine but also in submandibular salivary glands; thus, confirming the potential correlation between dietary AGEs and periodontal pathology, recently suggested by several studies [43]. Interestingly, the specific Maillard reaction product we detected was CML, which is a chemical entity different from MG-H1 and not included in the modified diet.…”

Section: Discussionsupporting

confidence: 90%

Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation

et al. 2020

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Heat-processed diets contain high amounts of advanced glycation end products (AGEs). Here we explore the impact of an AGE-enriched diet on markers of metabolic and inflammatory disorders as well as on gut microbiota composition and plasma proteins glycosylation pattern. C57BL/6 mice were allocated into control diet (CD, n = 15) and AGE-enriched diet (AGE-D, n = 15) for 22 weeks. AGE-D was prepared replacing casein by methylglyoxal hydroimidazolone-modified casein. AGE-D evoked increased insulin and a significant reduction of GIP/GLP-1 incretins and ghrelin plasma levels, altered glucose tolerance, and impaired insulin signaling transduction in the skeletal muscle. Moreover, AGE-D modified the systemic glycosylation profile, as analyzed by lectin microarray, and increased Nε-carboxymethyllysine immunoreactivity and AGEs receptor levels in ileum and submandibular glands. These effects were associated to increased systemic levels of cytokines and impaired gut microbial composition and homeostasis. Significant correlations were recorded between changes in bacterial population and in incretins and inflammatory markers levels. Overall, our data indicates that chronic exposure to dietary AGEs lead to a significant unbalance in incretins axis, markers of metabolic inflammation, and a reshape of both the intestinal microbiota and plasma protein glycosylation profile, suggesting intriguing pathological mechanisms underlying AGEs-induced metabolic derangements.

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Section: Discussionsupporting

confidence: 90%

Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation

et al. 2020

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“…These findings show that exposure to MMA monomers could be a starting point in oxidative stress initiation. At high levels, ROS can overwhelm cellular antioxidants, opening the way to oxidative stress and initiate oxidative attacks on important cellular macromolecules, such as proteins, lipids, and DNA [ 63 ].…”

Section: Possible Toxic Effects Of Pmma-based Dental Materials On mentioning

confidence: 99%

A Review on the Biocompatibility of PMMA-Based Dental Materials for Interim Prosthetic Restorations with a Glimpse into Their Modern Manufacturing Techniques

et al. 2020

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This paper’s primary aim is to outline relevant aspects regarding the biocompatibility of PMMA (poly(methyl methacrylate))-based materials used for obtaining interim prosthetic restorations, such as the interaction with oral epithelial cells, fibroblasts or dental pulp cells, the salivary oxidative stress response, and monomer release. Additionally, the oral environment’s biochemical response to modern interim dental materials containing PMMA (obtained via subtractive or additive methods) is highlighted in this review. The studies included in this paper confirmed that PMMA-based materials interact in a complex way with the oral environment, and therefore, different concerns about the possible adverse oral effects caused by these materials were analyzed. Adjacent to these aspects, the present work describes several advantages of PMMA-based dental materials. Moreover, the paper underlines that recent scientific studies ascertain that the modern techniques used for obtaining interim prosthetic materials, milled PMMA, and 3D (three-dimensional) printed resins, have distinctive advantages compared to the conventional ones. However, considering the limited number of studies focusing on the chemical composition and biocompatibility of these modern interim prosthetic materials, especially for the 3D printed ones, more aspects regarding their interaction with the oral environment need to be further investigated.

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“…By predicting the functional interactions between nutrients and genomes, the emerging and developing field of personalized medicine can incorporate nutrition, facilitating the step forward toward personalized cancer therapy. This is based on the capacity of certain nutrients to specifically activate cancer inhibitory mechanisms, thereby targeting important hallmarks of cancer like apoptosis or the impairment of angiogenesis [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention

et al. 2019

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Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be investigated and analyzed in terms of cancer’s predisposition, development and prognosis. One of these multi-dimensional factors, which has gained increased attention in the oncological field due to its unelucidated role in risk assessment for cancer, is diet. Moreover, as studies advance, a clearer connection between diet and the molecular alteration of patients is becoming identifiable and quantifiable, thereby replacing the old general view associating specific phenotypical changes with the differential intake of nutrients. Respectively, there are two major fields concentrated on the interrelation between genome and diet: nutrigenetics and nutrigenomics. Nutrigenetics studies the effects of nutrition at the gene level, whereas nutrigenomics studies the effect of nutrients on genome and transcriptome patterns. By precisely evaluating the interaction between the genomic profile of patients and their nutrient intake, it is possible to envision a concept of personalized medicine encompassing nutrition and health care. The list of nutrients that could have an inhibitory effect on cancer development is quite extensive, with evidence in the scientific literature. The administration of these nutrients showed significant results in vitro and in vivo regarding cancer inhibition, although more studies regarding administration in effective doses in actual patients need to be done.

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Advanced glycation end products (AGEs) in oral pathology

Cited by 38 publications

References 67 publications

Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation

Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation

A Review on the Biocompatibility of PMMA-Based Dental Materials for Interim Prosthetic Restorations with a Glimpse into Their Modern Manufacturing Techniques

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention

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