Advanced Electrospun Nanofibrous Stem Cell Niche for Bone Regenerative Engineering

Hosseini, Fatemeh S.; Laurencin, Cato T.

doi:10.1007/s40883-022-00274-x

Cited by 2 publications

(3 citation statements)

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“…As a result, a necrotic core develops, inhib. 1,2 After the blood transfusion, bone graft surgeries are the second most ingeminated tissue transplantation after blood transfusion. 3 More than two million surgical grafting procedures are conducted worldwide, with an approximate cost of $2.2 billion per year.…”

Section: Applications Of Oxygen-releasing Biomaterials For Bone Regen...mentioning

confidence: 99%

“…During osseointegration and bone regeneration, interior donor cells are subjected to limited nutrition and excessive waste buildup if the matrices are larger than the diffusional limits of oxygen and nutrients. As a result, a necrotic core develops, inhib. , After the blood transfusion, bone graft surgeries are the second most ingeminated tissue transplantation after blood transfusion . More than two million surgical grafting procedures are conducted worldwide, with an approximate cost of $2.2 billion per year.…”

Section: Applications Of Oxygen-releasing Biomaterials For Bone Regen...mentioning

confidence: 99%

“…Musculoskeletal diseases encompass over 50% of all chronic disorders in over-50-years-old populations of both genders in developed nations. , After blood transfusions, bone graft surgeries are the second most ingeminated tissue transplantation . More than two million surgical grafting procedures are conducted worldwide, with an approximate cost of $2.2 billion per year.…”

Section: Introductionmentioning

confidence: 99%

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Oxygen-Generating Biomaterials for Translational Bone Regenerative Engineering

Hosseini

Abedini

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Successful regeneration of critical-size defects remains one of the significant challenges in regenerative engineering. These large-scale bone defects are difficult to regenerate and are often reconstructed with matrices that do not provide adequate oxygen levels to stem cells involved in the regeneration process. Hypoxia-induced necrosis predominantly occurs in the center of large matrices since the host tissue’s local vasculature fails to provide sufficient nutrients and oxygen. Indeed, utilizing oxygen-generating materials can overcome the central hypoxic region, induce tissue in-growth, and increase the quality of life for patients with extensive tissue damage. This article reviews recent advances in oxygen-generating biomaterials for translational bone regenerative engineering. We discussed different oxygen-releasing and delivery methods, fabrication methods for oxygen-releasing matrices, biology, oxygen’s role in bone regeneration, and emerging new oxygen delivery methods that could potentially be used for bone regenerative engineering.

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Section: Applications Of Oxygen-releasing Biomaterials For Bone Regen...mentioning

confidence: 99%