Advanced control approaches for combined cooling/antisolvent crystallization in continuous mixed suspension mixed product removal cascade crystallizers

Yang, Yang; Nagy, Zoltán K.

doi:10.1016/j.ces.2015.01.060

Cited by 62 publications

(75 citation statements)

References 35 publications

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“…In recent years, researchers have focused on improving the mixing efficiency by using various feed modes, the antisolvent‐solution contact approach, additional physical fields (electric, magnetic, etc. ), and novel feeding devices and crystallizers . However, because antisolvent transfer is based on the droplet or capillary mixing approach, the fundamental mixing mechanism is still limited by the mixing devices with a millimeter or submillimeter scale (10 −4 ‐10 −3 m).…”

Section: Introductionmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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Herein, a novel hollow fiber membrane‐assisted antisolvent crystallization (MAAC) was proposed to enhance the mass transfer control over the antisolvent crystallization. A polyethersulfone membrane module was introduced as the key device for antisolvent transfer and solution mixing. An antisolvent liquid film layer was formed on the membrane surface and mixed with the solution. The liquid film also prevented the membrane from directly contacting with crystallization solution. By controlling both the shell side flow velocity and the antisolvent transfer, the antisolvent permeation rate achieved sensitive, stable, and accurate control during long‐term and repeated utilization. The interfacial mass transfer rate of MAAC was 0.66 mg cm−2 s−1, which was only 1/50 that of conventional droplet antisolvent crystallization. MAAC also provided crystal products with better morphologies and narrower size distributions than the conventional process. The stable performances of MAAC in terms of its accurate antisolvent mass transfer and antifouling capabilities were also highlighted. © 2018 American Institute of Chemical Engineers AIChE J, 65: 734–744, 2019

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Section: Introductionmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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“…The continuous MSMPR crystallization is a nonlinear distributed-parameter system, therefore, control design is a challenging task. Different strategies have been proposed including robust control [9][10][11], C-control [12], decentralized PID, nonlinear model predictive control (NMPC) [13], and direct nucleation control [14]. A Lyapunov-function-based approach called discrepancy-based control was presented in [15] and generalized to particle systems in [16].…”

Section: Discrepancy-based Controlmentioning

confidence: 99%

Control of Continuous Mixed‐Solution Mixed‐Product Removal Crystallization Processes

et al. 2017

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Continuous mixed-solution mixed-product removal (MSMPR) crystallization is considered. This process has been studied well, however, different aspects, in particular, process modeling, monitoring, and control remain challenging. An innovative approach for online measurement of the crystal size distribution is presented. Furthermore, unscented Kalman filtering is applied to overcome biased concentration measurement. Finally, a discrepancy-based control is applied to continuous MSMPR crystallization and its closed-loop performance is evaluated.

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“…13,[32][33][34] In addition, there are several recent reports about the optimization of the multistage MSMPR crystallizer. 8,9,[35][36][37] However, no general analysis of the effects of various crystallization kinetic parameters on the effective operating strategy for the crystallization system has been carried out. This kind of analysis is important because it can be a guideline for the appropriate design and operation of a continuous multistage MSMPR crystallization process when the crystallization kinetic data are available.…”

Section: Introductionmentioning

confidence: 99%

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

Park

Kim

Yang

2016

Ind. Eng. Chem. Res.

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Continuous multistage MSMPR crystallization processes are useful for the large scale production of particulate systems. However, the design of operating strategies to meet specific objectives and materials has not been entirely investigated. In this work, the effect of important crystallization kinetic parameters on the optimal operating strategy was examined. The important parameters are the kinetic constants of the primary and secondary nucleation rates, the orders of the nucleation and growth rates, and the number of crystallizer stages. The analyses revealed that a drastic cooling strategy in the primary nucleation dominant region and linear cooling in the secondary nucleation dominant region are best for producing large particle sizes. A stage number of around three is effective in both regions.These results can be utilized to roughly determine the operating strategy for a process, if the crystallization kinetic parameters are already roughly known.

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Advanced control approaches for combined cooling/antisolvent crystallization in continuous mixed suspension mixed product removal cascade crystallizers

Cited by 62 publications

References 35 publications

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

Control of Continuous Mixed‐Solution Mixed‐Product Removal Crystallization Processes

Operating Strategy for Continuous Multistage Mixed Suspension and Mixed Product Removal (MSMPR) Crystallization Processes Depending on Crystallization Kinetic Parameters

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