Advanced applications of strontium-containing biomaterials in bone tissue engineering

Sheng, Xiao Min; Li, Chen; Wang, Zhonghan; Xu, Yu; Sun, Yang; Zhang, Weimin; Liu, He; Wang, Jincheng

doi:10.1016/j.mtbio.2023.100636

Cited by 17 publications

(11 citation statements)

References 247 publications

(297 reference statements)

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“…12 However, maintaining the biological activity of these biological molecules is a big challange, and suitable encapsulating materials are generally needed to control their release into the wounds. Bioactive glass (bioglass), originally developed and extensively used for bone repair, 13–15 has demonstrated a positive role in wound healing in recent years. 16,17 A multitude of research studies have demonstrated that bioglass holds promise as a wound healing promoter due to its remarkable potential to significantly enhance and activate the cellular behaviors of inflammatory cells, fibroblasts, and endothelial cells, as well as their intricate interplay.…”

Section: Introductionmentioning

confidence: 99%

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Fan

Razal

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Fan

Razal

et al. 2023

J. Mater. Chem. B

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“…The literature has reported the potential of Sr 2+ in increasing alkaline phosphatase (ALP) activities, collagen synthesis and the expression of osteoblastic markers, leading to increased osteogenesis [19]. However, the long-term systemic use of Sr 2+ is associated with serious adverse reactions, such as the risk of myocardial infarction, thromboembolic events and severe skin reactivity, with its indication being limited to the treatment of severe osteoporosis by the European Drug Administration in 2013 [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, studies addressing Sr-doped BG are of great relevance as BG allows the local release of Sr 2+ , avoiding negative reactions associated with its long-term systemic use [20]. However, there are still challenges related to Sr-containing BG, since an in-depth study of the incorporated amounts of this element is necessary, as high amounts of Sr can have negative effects on the biological properties of BG.…”

Section: Introductionmentioning

confidence: 99%

Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration

Silva,

Gomes,

Victor

et al. 2023

Materials

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Bioactive glasses (BGs) can potentially be applied in biomedicine, mainly for bone repair and replacement, given their unique ability to connect to natural bone tissue and stimulate bone regeneration. Since their discovery, several glass compositions have been developed to improve the properties and clinical abilities of traditional bioactive glass. Different inorganic ions, such as strontium (Sr2+), have been incorporated in BG due to their ability to perform therapeutic functions. Sr2+ has been gaining prominence due to its ability to stimulate osteogenesis, providing an appropriate environment to improve bone regeneration, in addition to its antibacterial potential. However, as there are still points in the literature that are not well consolidated, such as the influence of ionic concentrations and the BG production technique, this review aims to collect information on the state of the art of the biological behavior of BGs containing Sr2+. It also aims to gather data on different types of BGs doped with different concentrations of Sr2+, and to highlight the manufacturing techniques used in order to analyze the influence of the incorporation of this ion for bone regeneration purposes.

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“…hydroxyapatite (HA) in natural bone and possesses excellent biocompatibility and osteogenic activity. 5,6 α-tricalcium phosphate (α-TCP) powder, which readily reacts with water to form calcium-deficient hydroxyapatite (CDHA), is frequently used in bone cements. 7,8 However, despite its excellent biocompatibility and easy injectability for bone reconstruction, the applicability of α-TCP is limited by the manual preparation method, with the operator's skill level affecting the setting time and mechanical properties.…”

mentioning

confidence: 99%

“…However, Cu cannot completely block the hydraulic reaction; it only delays it. Of all these heavy metals, Cu [18][19][20][21] and Sr 5,22 are well known for their osteogenic and angiogenic properties and are widely applied in bone tissue. In addition, Cu is a well-established antibacterial metal widely used as an antibacterial agent.…”

mentioning

confidence: 99%

Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

Shu,

Liao,

Wang

et al. 2024

J Biomedical Materials Res

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The increasing prevalence of implant‐associated infections (IAI) in orthopedics remains a public health challenge. Calcium phosphates (CaPs) are critical biomaterials in dental treatments and bone regeneration. It is highly desirable to endow CaPs with antibacterial properties. To achieve this purpose, we developed a photocrosslinked methacrylated alginate co‐calcium phosphate cement (PMA‐co‐PCPC) with antibacterial properties, using α‐tricalcium phosphate (α‐TCP) powders with 16% amorphous contents as solid phase, liquid phases containing CuCl2 and SrCl2 as an inhibitor, and CaCl2 as an activator to construct PCPC. When CaCl2 started to activate the hydration reaction, Sr2+ or Cu2+ ions were exchanged with Ca2+, and α‐TCP dissolution was restarted and gradually hydrated to form calcium‐deficient hydroxyapatite (CDHA). PMA was added to crosslink with Cu/Sr ions and form gel‐layer‐wrapped hydrated CDHA. This study explored the binding mechanism of PMA and PCPC and the ion release rule of Ca2+ → Sr2+/Cu2+, optimized the construction of several antibacterial PMA‐co‐PCPC materials, and analyzed the physical, chemical, and biological properties. Because of the combined effect of Cu and Sr ions, the scaffold exhibited a potential antibacterial activity, promoting bone formation and vascular regeneration. This work provides a basis for designing antibacterial calcium phosphate biomaterials with controllable treatment, which is an important characteristic for preventing IAI of biomaterials.

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Advanced applications of strontium-containing biomaterials in bone tissue engineering

Cited by 17 publications

References 247 publications

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration

Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

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