Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration

Silva, Amanda Vieira; Gomes, Déborah dos Santos; Victor, Rayssa de Sousa; Santana, Lisiane Navarro de Lima; Neves, Gelmires Araújo; Menezes, Romualdo Rodrigues

doi:10.3390/ma16247654

Cited by 5 publications

(1 citation statement)

References 147 publications

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“…Additionally, the presence of Sr 2+ ions in the CPs-based implants can positively impact bone tissue due to their physiological similarity to calcium ions [19]. The presence of Sr 2+ ions in the implant can stimulate osteogenesis [20], and increase adhesion, proliferation and differentiation of osteoblasts [21,22]. The controlled release of a specific amount of Sr 2+ ions can facilitate the healing of osteoporotic bone defects [23].…”

Section: Introductionmentioning

confidence: 99%

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Lebedev,

Kharovskaya,

Lazoryak

et al. 2024

Biomimetics

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β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca9.5–xSrxCu(PO4)7 was obtained by the method of solid-phase reactions. The Rietveld method of structural refinement revealed the presence of Sr2+ ions in four crystal sites: M1, M2, M3, and M4. The M5 site is completely occupied by Cu2+. Isomorphic substitution of Ca2+ → (Sr2+and Cu2+) expands the concentration limits of the existence of the solid solution with the β-TCP structure. No additional phases were formed up to x = 4.5 in Ca9.5–xSrxCu(PO4)7. Biocompatibility tests were performed on cell lines of human bone marrow mesenchymal stromal cells (hMSC), human fibroblasts (MRC-5) and osteoblasts (U-2OS). It was demonstrated that cytotoxicity exhibited a concentration dependence, along with an increase in osteogenesis and cell proliferation. Ca9.5–xSrxCu(PO4)7 powders showed significant inhibitory activity against pathogenic strains Escherichia coli and Staphylococcus aureus. Piezoelectric properties of Ca9.5–xSrxCu(PO4)7 were investigated. Possible ways to achieve high piezoelectric response are discussed. The combination of bioactive properties of Ca9.5–xSrxCu(PO4)7 renders them multifunctional materials suitable for bone substitutes.

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Section: Introductionmentioning

confidence: 99%

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Lebedev,

Kharovskaya,

Lazoryak

et al. 2024

Biomimetics

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Calcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies

dos Santos Gonçalves,

Donda,

de Oliveira Filho

et al. 2024

Res. Biomed. Eng.

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Osteoblast and osteoclast activity on collagen-based 3D printed scaffolds enriched with strontium-doped bioactive glasses and hydroxyapatite nanorods for bone tissue engineering

Borciani,

Montalbano,

Perut

et al. 2024

Biomed. Mater.

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Bone tissue engineering (BTE) aims to promote bone regeneration by means of the synergistic effect of biomaterials, cells, and other factors, as potential alternative to conventional treatments for bone fractures. To this aim, a composite material was developed, based on collagen type I, strontium-enriched mesoporous bioactive glasses, and hydroxyapatite nanoparticles as bioactive and biomimetic components. Nanostructured scaffolds were 3D printed and subsequently chemically crosslinked with genipin to improve mechanical properties and stability. The developed nanostructured system was maintained in culture until 3 weeks with a co-culture of human bone cells to provide an ex vivo model of bone microenvironment and examine the cellular crosstalk and signaling pathways through paracrine cell activities. Human osteoblasts (OBs), derived from trabecular bone, and human osteoclast precursors (OCs), isolated from buffy coat samples were involved, with OBs seeded on the scaffold and OCs precursors seeded in a transwell device. When compared to the material without inorganic components, the bioactive and biomimetic scaffold positively influenced cell proliferation and cell metabolic activity, boosting alkaline phosphatase activity of osteoblasts, and reducing osteoclast differentiation. Thus, the bioactive and biomimetic system promoted an enhanced cellular response, highlighting its potential application in bone tissue engineering.

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Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration

Cited by 5 publications

References 147 publications

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Calcium aluminate cement blended to bioactive glass and strontium: in vitro and in vivo evaluation studies

Osteoblast and osteoclast activity on collagen-based 3D printed scaffolds enriched with strontium-doped bioactive glasses and hydroxyapatite nanorods for bone tissue engineering

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