Advanced application of collagen-based biomaterials in tissue repair and restoration

Zhu, Jiayi; Li, Zhulian; Zou, Yaping; Lu, Gonggong; Ronca, Alfredo; D’Amora, Ugo; Liang, Jie; Fan, Yujiang; Zhang, Xingdong; Sun, Yong

doi:10.1186/s42825-022-00102-6

Cited by 40 publications

(20 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned in several studies, collagen has poor mechanical properties in regenerative medicine applications 72 , 73 . Compressing collagen constructs is a promising method for improving their mechanical properties in tissue engineering applications.…”

Section: Discussionmentioning

confidence: 99%

Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration

Takallu,

Kakian,

Bazargani

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The effective control of pathogenic bacteria is crucial in the restoration of periodontal tissue affected by periodontitis. Guided tissue regeneration (GTR) membranes are commonly used to aid in the repair of periodontal defects. Therefore, there is a clear advantage in developing antibacterial periodontal membranes that can effectively eliminate infections and promote tissue regeneration. This study aimed to create a collagen membrane with optimal content of silver nanoparticles (AgNPs) for effective antibacterial properties and minimal toxicity to mammalian cells. Ascorbic acid-reduced AgNPs were incorporated into collagen at the ratio of 0.5%, 1%, 2%, and 3% (based on total dry weight). Collagen/AgNPs hydrogels were compressed and freeze-dried to form membranes and then were characterized. Antibacterial activity was tested against Fusobacterium nucleatum and Enterococcus faecalis, and membrane cytocompatibility was accomplished on human gingival fibroblasts. Membranes with 2% and 3% AgNPs exhibited significant antibacterial activity, while 1% showed minimal activity and 0.5% and 0% showed none. HGF cells on the 3% AgNPs membrane had poor viability, proliferation, and adhesion, but 0%, 0.5%, 1%, and 2% AgNPs membranes showed desirable cellular behavior. In conclusion, the collagen membrane with 2% AgNPs demonstrated both antibacterial capacity and excellent cytocompatibility, making it a promising choice for periodontal treatments, especially in GTR approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration

Takallu,

Kakian,

Bazargani

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Moreover, bone is a load-bearing organ with certain mechanical strength, and biomaterials with the same Young’s modulus as bone are highly sought after. For repairable bone injuries, biomaterials are generally selected to be biodegradable at a rate comparable to the bone healing cycle ( Borchers and Pieler, 2010 ; Gorejová et al, 2018 ; Zhu et al, 2022 ).…”

Section: Interaction Of Materials and Immune Cellsmentioning

confidence: 99%

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Dong

Tan

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.

show abstract

“…Although some studies have reported that the addition of collagen to fibrin hydrogels can improve their mechanical properties, there is still room for improvement to achieve optimal stiffness and elasticity for different tissue types. 237 Additionally, some drawbacks have been reported in the application of these types of hydrogels, such as the low mechanical strength and low osteogenicity of collagen, limiting their application in bone regeneration 238 ; thrombogenic properties and in vivocalcification in cardiovascular repair 238 ; and the lack of revascularization in multilayered tissues. 239 The combination of fibrin and alginate has also shown promise in promoting the growth of ovarian follicles and bone tissue regeneration.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Technological advances in fibrin for tissue engineering

et al. 2023

View full text Add to dashboard Cite

Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.

show abstract

Advanced application of collagen-based biomaterials in tissue repair and restoration

Cited by 40 publications

References 143 publications

Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration

Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Technological advances in fibrin for tissue engineering

Contact Info

Product

Resources

About