Adult Wilms' tumor. Report of two cases and review of the literature

Hentrich, Marcus; Meister, P.; Brack, N.; Lutz, Ludwig; Hartenstein, R.

doi:10.1002/1097-0142(19950115)75:2<545::aid-cncr2820750218>3.0.co;2-c

Cited by 36 publications

(17 citation statements)

References 42 publications

(3 reference statements)

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“…The 'late' paediatric cancers normally associated with childhood included rhabdomyosarcoma (26 cases), medulloblastoma (14), neuroblastoma (seven), hepatoblastoma (two) and Wilms' tumour (one). There have been other anecdotal reports of such 'late' paediatric cancers in adult patients (Hollowood and Fletcher, 1994;Hentrich et al, 1995;Paterson and Walker, 1995;Moody et al, 1996;Varona and Ruiz, 1996). The cancers which are 'largely specific' to adolescents and young adults include bone tumours and testicular cancer.…”

Section: Young Adultsmentioning

confidence: 98%

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

et al. 2000

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The Northern Region Young Persons’ Malignant Disease Registry records information on young people under 25 years old diagnosed with cancer in the Northern Region of England. Incidence and survival rates were calculated for children and young adults diagnosed with cancer between 1968 and 1995. There were 2099 (M:F 1.28:1) children (age 0–14 years) and 2217 (M:F 1.23:1) young adults (15–24 years) diagnosed with a first cancer between 1968 and 1995. The age-standardized rate (ASR) for childhood cancer was 121 per million 0 to 14 year-olds per year. For young adults the ASR was 175 per million 15 to 24 year-olds, per year. Incidence of childhood cancer increased over time at a rate of 12 extra cases per million children, per decade ( P < 0.001). In young adults incidence rates increased by 16 extra cases per million 15 to 24 year-olds, per decade ( P < 0.001). For childhood cancer 5-year survival was 42% for those diagnosed 1968–1977, 57% for 1978–1987 and 71% (95% CI 67–75) for 1988–1995. Survival for young adults over the three periods was 45%, 62% and 73% (95% CI 70–78) respectively. The cumulative risk of developing cancer before the age of 25 is 1 in 285. Over the 28-year period there were significant improvements in survival and modest increases in incidence in both children and young adults. © 2000 Cancer Research Campaign

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Section: Young Adultsmentioning

confidence: 98%

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

et al. 2000

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The 2 primary multi-institutional Wilms' tumor cooperative groups, the National Wilms Tumor Study Group (NWTS) and the International Society of Paediatric Oncology (SIOP), have each published analyses of adult Wilms' tumor cases registered on their respective trials. 19,20 The publications from these groups were based on adult (!16 years) subsets that were treated identically to the children on protocol with overall and disease-free survival results comparable to those of the children.…”

Section: Introductionmentioning

confidence: 99%

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

Ali¹,

Díaz²,

Shu³

et al. 2011

Cancer

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PURPOSE:To compare the characteristics and outcome of adults and children diagnosed with Wilms' tumor. METHODS: The Surveillance, Epidemiology and End Results (SEER) database was analyzed for patients diagnosed with Wilms' tumor between 1973 and 2007. Patients were stratified into pediatric (<16 years) or adult (!16 years) groups. Overall survival was the primary endpoint. RESULTS: A total of 2342 patients (2190 pediatric and 152 adult) with Wilms' tumor were identified. Adult patients were statistically more likely to be staged as localized than pediatric patients (62.5% vs 44.7%), to not receive any lymph node sampling (57.9% vs 16.2%), and to not receive any radiation treatment (74.3% vs 53.9%). Adults had a statistically worse overall survival (OS) than pediatric patients (5-year OS, 69% vs 88%, P<.001) despite the earlier tumor stage. When stratified by treatment era, the OS of all patients treated after 1981 was statistically higher than those treated before (5-year OS, 75% vs 89%, P<.001). Significant predictors of OS on univariate analysis for adults included treatment era, SEER stage, surgery, and radiation treatment. Significant predictors of OS on multivariate analysis of all patients included adult status (hazard ratio, 4.14; P<.001), treatment era, SEER stage, and surgery. CONCLUSION: Adults in the SEER database had statistically worse OS than pediatric patients despite previous studies showing comparable outcome when treated on protocol. The worse outcome of SEER adults likely stems from incorrect diagnosis, inadequate staging and undertreatment. We recommend lymph node samplings for all adult Wilms' tumor patients and collaboration with pediatric oncologists. Cancer 2012;118:2541-

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“…Nephroblastoma or Wilms' tumor accounts for around about 5-6 % of neoplasms in childhood, it occurrence is rare accounting to less than 3% in the adult population [3]. The worse biological behavioural pattern of Wilms' tumor is unexplained [4].…”

Section: Discussionmentioning

confidence: 99%

An Uneventful Pregnancy and Delivery in a Metastatic Adult Wilms’ Tumor–A Rare Case Report

Martin¹

2017

MOJCR

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Adult Wilms' tumor (AWT) is a malignant embryonic renal neoplasm. It has an incidence of less than 0.2 per million per year which signifies its rarity in adults. Herein, we report a case of adult Wilms tumor who has had a successful pregnancy and delivery against her odds of a metastatic disease. There is a dearth of information about this rare disease, which makes its management quite challenging [1].

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Adult Wilms' tumor. Report of two cases and review of the literature

Cited by 36 publications

References 42 publications

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

An Uneventful Pregnancy and Delivery in a Metastatic Adult Wilms’ Tumor–A Rare Case Report

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