Incidence and survival for cancer in children and young adults in the North of England, 1968–1995: a report from the Northern Region Young Persons’ Malignant Disease Registry

Abstract

The Northern Region Young Persons’ Malignant Disease Registry records information on young people under 25 years old diagnosed with cancer in the Northern Region of England. Incidence and survival rates were calculated for children and young adults diagnosed with cancer between 1968 and 1995. There were 2099 (M:F 1.28:1) children (age 0–14 years) and 2217 (M:F 1.23:1) young adults (15–24 years) diagnosed with a first cancer between 1968 and 1995. The age-standardized rate (ASR) for childhood cancer was 121 per million 0 to 14 year-olds per year. For young adults the ASR was 175 per million 15 to 24 year-olds, per year. Incidence of childhood cancer increased over time at a rate of 12 extra cases per million children, per decade ( P < 0.001). In young adults incidence rates increased by 16 extra cases per million 15 to 24 year-olds, per decade ( P < 0.001). For childhood cancer 5-year survival was 42% for those diagnosed 1968–1977, 57% for 1978–1987 and 71% (95% CI 67–75) for 1988–1995. Survival for young adults over the three periods was 45%, 62% and 73% (95% CI 70–78) respectively. The cumulative risk of developing cancer before the age of 25 is 1 in 285. Over the 28-year period there were significant improvements in survival and modest increases in incidence in both children and young adults. © 2000 Cancer Research Campaign

Classification and incidence of cancers in adolescents and young adults in England 1979–1997

“…The rates shown in Table 3 are largely consistent with those found in a small study in this age group in the Northern Region of England and which partially overlaps with the present study (Cotterill et al, 2000). However, the Northern Region study included less than one tenth the number of cases in the present study and variations in rates with respect to diagnostic sub-groups are probably due to the very small numbers resulting in unstable rates for a number of the groups.…”

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

“…Other studies have also shown a general improvement in survival for childhood CNS tumours over the last [20][21][22][23][24][25][26][27][28][29][30] years identifying improvements in CNS embryonal tumour survival specifically (3,16,19,30,31). TYA, aged 16-24 years, from Yorkshire showed a significant increase in survival from medulloblastoma and CNS PNET combined between 1990 and 2009 (32).…”

“…Central nervous system (CNS) tumours are the second most common site of neoplasms diagnosed in children, accounting for approximately one quarter of all childhood cancers (0-14 years), (1) and 14% of tumours diagnosed in teenagers and young adults (TYA) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24) years) (2). They are the most common cause of cancer related death in children and TYA (1,2).…”

Outcome of a risk-related therapeutic strategy used prospectively in a population-based study of Hodgkin's lymphoma in adolescents

“…In addition, the Northern Region Young Person's Malignancy Registry (NRYPMR) collects data at presentation from all patients, aged p25 years diagnosed with a malignant disease in the same geographical area (Cotterill et al, 2000). Patients were included in the present study if they presented between 1 January 1991 and 31 December 2000 with histologically confirmed, newly diagnosed HL, were aged 13 -19 years (inclusive) at diagnosis and were normally resident in the area at the time of diagnosis.…”