Adult Wilms’ tumor: A case report and review of literature

Kartsanis, Georgios; Douros, Konstantinos; Ravazoula, Panagiota; Fokaefs, Eleftherios

doi:10.1007/s11255-006-0029-y

Cited by 9 publications

(7 citation statements)

References 7 publications

(9 reference statements)

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] The 2 primary multi-institutional Wilms' tumor cooperative groups, the National Wilms Tumor Study Group (NWTS) and the International Society of Paediatric Oncology (SIOP), have each published analyses of adult Wilms' tumor cases registered on their respective trials. 19,20 The publications from these groups were based on adult (!16 years) subsets that were treated identically to the children on protocol with overall and disease-free survival results comparable to those of the children.…”

Section: Introductionmentioning

confidence: 99%

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

Ali¹,

Díaz²,

Shu³

et al. 2011

Cancer

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PURPOSE:To compare the characteristics and outcome of adults and children diagnosed with Wilms' tumor. METHODS: The Surveillance, Epidemiology and End Results (SEER) database was analyzed for patients diagnosed with Wilms' tumor between 1973 and 2007. Patients were stratified into pediatric (<16 years) or adult (!16 years) groups. Overall survival was the primary endpoint. RESULTS: A total of 2342 patients (2190 pediatric and 152 adult) with Wilms' tumor were identified. Adult patients were statistically more likely to be staged as localized than pediatric patients (62.5% vs 44.7%), to not receive any lymph node sampling (57.9% vs 16.2%), and to not receive any radiation treatment (74.3% vs 53.9%). Adults had a statistically worse overall survival (OS) than pediatric patients (5-year OS, 69% vs 88%, P<.001) despite the earlier tumor stage. When stratified by treatment era, the OS of all patients treated after 1981 was statistically higher than those treated before (5-year OS, 75% vs 89%, P<.001). Significant predictors of OS on univariate analysis for adults included treatment era, SEER stage, surgery, and radiation treatment. Significant predictors of OS on multivariate analysis of all patients included adult status (hazard ratio, 4.14; P<.001), treatment era, SEER stage, and surgery. CONCLUSION: Adults in the SEER database had statistically worse OS than pediatric patients despite previous studies showing comparable outcome when treated on protocol. The worse outcome of SEER adults likely stems from incorrect diagnosis, inadequate staging and undertreatment. We recommend lymph node samplings for all adult Wilms' tumor patients and collaboration with pediatric oncologists. Cancer 2012;118:2541-

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Section: Introductionmentioning

confidence: 99%

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

Ali¹,

Díaz²,

Shu³

et al. 2011

Cancer

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“…Small case series, single institution experiences, and population based studies have reported significantly worse survival for adult WT than pediatric WT. 2,5,[11][12][13][14][15][16][17][18] In contrast, multi-institutional cooperative WT studies have reported comparable outcomes to that of children when patients are treated with protocol-driven, risk-stratified, multimodal therapy. 19,20 Given the conflicting data available, this study sought to evaluate WT treatment patterns and outcomes based on age using data captured by the NCDB, a large national database that captures patients across all ages, not just those enrolled on study.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Care and Survival Comparison of Adult and Pediatric Wilms Tumor in the United States: A Study of the National Cancer Database

Saltzman

Carrasco

Amini

et al. 2020

Urology

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“…Wilms' tumor or nephroblastoma is a malignant embryonal tumor of the kidney made up of embryonic cells and commonly found among children below five years old [1] , [2] . It is infrequent in adults and usually has poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…It is infrequent in adults and usually has poor prognosis. Adult Wilms' tumor can be diagnosed using criteria outlined by Klinton et al such as 1) tumor is identified as primary renal neoplasm 2) presence of primitive blastemic spindle or round cell component 3) formation of abortive or embryonal tubules or glomerular structures 4) absence of renal cell carcinoma around tumor area 5) histologically confirmed 6) age above 15 years old [2] .…”

Section: Introductionmentioning

confidence: 99%

Inferior vena cava thrombus shrinkage in patient with adult Wilms' tumor: A Case report

Ferry

Safriardi

Pramod

et al. 2022

International Journal of Surgery Case Reports

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Introduction and importance Adult Wilms' tumor is infrequent in adults and usually has poor prognosis. We report a case of inferior vena cava thrombus shrinkage in patient with adult Wilms' tumor. Case presentation A 27-year-old male came to hospital due to pain in his left flank and repeated hematuria since one year ago. An inhomogeneous mass and thrombus in IVC and abdominal aorta near renal artery were found from his abdominal CT scan with contrast, so cytoreductive nephrectomy was performed. However, the patient was unstable during operation so the thrombus couldn't be operated. Post-op immuno-histo-chemistry evaluation conethicfirmed the diagnosis of adult Wilms Tumor. A follow-up CT scan with contrast showed shrinkage of thrombus size with no sign of peripheral congestion. This phenomenon was rare in adult Wilms tumors, especially when the patient didn't undergo thrombus removal or adjuvant chemotherapy. Clinical discussion Adult Wilms' tumor tends to invade blood vessels in the form of thrombus, as shown in this case. Up to 4% of patients with thrombus had it around vena cava [3,4]. The recommended treatment is open surgery. Patients with chronic thrombus obstruction might have several venous collateral pathways to maintain blood flow to the right atrium. Generally, there are three major alternative pathways found in such complications. Conclusion This study presented a patient with adult Wilms' tumor that experienced post-operative thrombus shrinkage without doing adjuvant chemotherapy or thrombus removal during surgery.

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Adult Wilms’ tumor: A case report and review of literature

Cited by 9 publications

References 7 publications

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor

Patterns of Care and Survival Comparison of Adult and Pediatric Wilms Tumor in the United States: A Study of the National Cancer Database

Inferior vena cava thrombus shrinkage in patient with adult Wilms' tumor: A Case report

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