Adult T-Cell Leukemia/Lymphoma

Qayyum, Sohail; Choi, John K.

doi:10.5858/arpa.2012-0379-rs

Cited by 51 publications

(51 citation statements)

References 33 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human T‐cell Lymphotropic Virus type 1 can be transmitted through mother‐to‐child transmission (MTCT), mainly by breastfeeding; sexually or via blood. ATLL occurs mostly in adults, at least 20–30 years after the HTLV‐1 infection, mainly in those infected in childhood, and it seldom arises in those infected in adulthood . Consistently – although there are some reported cases of ATLL associated with sexual transmission or blood transfusion – several studies have shown that most cases of ATLL develop in individuals who were infected with HTLV‐1 as young children via breastfeeding .…”

Section: Introductionmentioning

confidence: 93%

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Eusebio‐Ponce

Candel

Anguita

2019

Tropical Med Int Health

View full text Add to dashboard Cite

This narrative review, which is based on a systematic literature search following the PRISMA guidelines, provides a general overview of Human T-cell Lymphotropic Virus type 1 (HTLV-1) and associated diseases: Adult T-cell Leukaemia-Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in Latin America, focusing on epidemiology and prevention. Using the published information on HTLV-1, ATLL and HAM/TSP prevalence, we present comprehensive and accurate maps and tables, and developed an algorithm to assist in the prevention of HTLV-1 transmission through breastfeeding while considering socio-economic status. Latin America is an interesting scenario to study HTLV-1 because of the diverse origin of its population. Apart from the expected high prevalence in inhabitants of African ancestry, the presence of endemic foci affecting indigenous populations is particularly striking. ATLL prevention is the biggest challenge in this field. Most ATLL cases are transmitted through breastfeeding; thus, prevention methods to avoid ATLL in endemic countries have to be focused on this. In view of the high inequality in most Latin American countries, reduction in breastfeeding duration, freezing/ thawing and pasteurisation of breastmilk can be suitable interventions in poor settings, considering that avoiding the risk of malnutrition and infant mortality must be the priority.

show abstract

Section: Introductionmentioning

confidence: 93%

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Eusebio‐Ponce

Candel

Anguita

2019

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…A high prevalence of carriers is reported in Japan (particularly on its southeastern Pacific coast), sub-Saharan Africa, northeastern South Africa, and the Caribbean islands. The annual incidence among carriers is known to be low, and it is 1.5/1,000 (men) and 0.5/1,000 (woman), and the cumulative life-long risk of ATLL is 2.5% (Yamaguchi 1994;Yamaguchi and Watanabe 2002;Qayyum and Choi 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Clinical features include lymphadenopathy (60%), hepatomegaly (26%), splenomegaly (22%), skin lesions (39%), and hypercalcemia (32%). Bone changes are seen in patients with acute type (Yamaguchi 1994;Yamaguchi and Watanabe 2002;Qayyum and Choi 2014).…”

Section: Introductionmentioning

confidence: 99%

Hand Osteolysis in Patients with Adult T-Cell Leukemia-Lymphoma: Radiographic Characteristics

Ehara

Takahashi

Nishida

et al. 2015

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Adult T-cell leukemia-lymphoma (ATLL) is caused by human T-cell lymphotrophic virus I (HTLV-I) infection. Among ATLL cases, 70% of patients present with leukemia and the remaining patients present with lymphoma. Hand osteolysis in the patients with ATLL is considered as paraneoplastic syndrome and caused by parathyroid hormone-related peptide (PTHrP) released from tumor cells. Radiographic features are similar to hyperparathyroidism, but the distribution of osteolysis in hands appears to be slightly different with the authors' experiences. The objective of this study was to identify radiographic characteristics of hand osteolysis associated with ATLL. We included six ATLL patients (5 men and 1 woman; age range, 45-71 years). All the patients presented with acute leukemia, and three were associated with hypercalcemia and pain in various locations including hands. Patterns of osteolysis on hand radiographs were evaluated and recorded independently by three musculoskeletal radiologists. We analyzed the distribution of the bone resorption in the ray distribution of the hand, finger predilection, and the difference between the ulnar and radial sides. The bone resorption was characterized by frequent involvement of the distal and proximal phalanges, predilection of ring fingers and prominent involvement on the ulnar side, compared with frequent involvement of proximal and middle phalanges, index and middle fingers, and on the radial side in the bone resorption of typical hyperparathyroidism. Such distribution may be a characteristic feature of hand osteolysis in patients with ATLL. The present findings are helpful for physicians to differentiate PTHrP-mediated osteolysis in ATLL from parathyroid hormone-mediated hyperparathyroidism.

show abstract

“…Adult T‐cell Leukemia/lymphoma (ATLL) is a rare and often aggressive T cell leukemia/lymphoma that can be found in the blood, lymph nodes, and multiple areas of the body. ATLL has been linked to infection by the human T‐cell lymphotropic virus type 1 (HTLV‐1) . HTLV‐1 is endemic in Southern Japan, Africa, Caribbean regions, and Latin America.…”

mentioning

confidence: 99%

Cytological diagnosis of adult T‐cell leukemia/lymphoma in sputum

Jia

Liu

Axiotis

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Adult T-cell leukemia/lymphoma (ATLL) is a rare and often aggressive T-cell leukemia/lymphoma that has been linked to infection by the human T-cell lymphotropic virus type 1 (HTLV-1). ATLL can involve multiple organs including the respiratory airway. A 53-year-old Trinidadian woman presented with productive cough and progressive shortness of breath. Her past medical history included duodenal strongyloidosis, skin rash, and hypercalcemia. Radiological studies showed increased interstitial markings. Sputum cytology showed atypical pleomorphic, small-to-medium-sized, lobated lymphocytes with irregular and hyperchromatic nuclei resembling "flower cells" which were CD3±/CD20- by immunocytochemistry. A lung biopsy showed interstitial, peribronchiolar, and subpleural infiltration by a CD3±/CD25± atypical lymphocytic infiltrate. Together with peripheral blood findings and positive HTLV-1 serology, the diagnosis of ATLL was made. We suggest that sputum evaluation in patients with ATLL risk factors can be diagnostic.

show abstract

Adult T-Cell Leukemia/Lymphoma

Cited by 51 publications

References 33 publications

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Human T‐Cell Lymphotropic Virus Type 1 and associated diseases in Latin America

Hand Osteolysis in Patients with Adult T-Cell Leukemia-Lymphoma: Radiographic Characteristics

Cytological diagnosis of adult T‐cell leukemia/lymphoma in sputum

Contact Info

Product

Resources

About