Adult Polycystic Disease of the Kidneys (Potter Type 3)

Hatfield, Philip M.

doi:10.1001/jama.1972.03210120025006

Cited by 60 publications

(16 citation statements)

References 6 publications

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“…These data are very similar to those recently described [2] and indicate that the progno sis for patients with APKD is better than previously reported some years ago [1,7], except for the study of Hatfield and Pfister [5], These authors had noted that symptomatic patients had a poorer prognosis than asymptomatic ones. In their series the average age of death was 51.8 years for symptomatic patients and 73.0 years for those without symptoms.…”

Section: Discussionsupporting

confidence: 90%

“…The incidence of hypertension has been described [1,[5][6][7][8][9][10][11], but there are some striking differences as its frequency varies from 13% reported by Milutinovic et al [9] to 81% of the patients in the Heidelberg study [11], also as initial manifestation. During follow-up, 73% of our patients were hypertensive, and the differ ence due to sex previously reported [9] has not been found in our population.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies indicate that hypertension portends a poor prognosis. Hatfield and Pfister [5] noted that patients with chronic renal failure and high blood pressure died, on average, 15 years earlier than patients with renal fail ure and normal blood pressure. Furthermore, Iglesias et al [ 12] find that the presence of hypertension at the time of diagnosis had an adverse and significant influence on kidney survival.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Prognosis of Adult Polycystic Kidney Disease

Gonzalo¹,

Rivera²,

Quereda³

et al. 1990

Am J Nephrol

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To appraise the prognosis of adult polycystic kidney disease (APKD), 107 patients (58 male and 49 female) were studied retrospectively. The mean age at the time of diagnosis was 45.9 years (ages ranging from 18 to 83 years). Ninety-eight patients had symptomatic APKD. At diagnosis, 30 of these patients had normal renal function, and 68 presented with chronic renal failure (serum creatinine higher than 1.5 mg/dl). Nine of the 107 patients were asymptomatic. Hypertension was the most common feature in symptomatic APKD, present in 51 % of these patients as initial manifestation, and was observed in 46 % of the patients with normal renal function. Forty of the 107 patients (37%) went into end-stage renal disease (ESRD) at a mean age of 52.7 years. The probability of being alive and not having ESRD, estimated using a time-to-event analysis, was 74% by the age of 50, 51 % by the age of 58 and 37% by the age of 70 years. Thus, the prognosis for patients with APKD is better than some reports suggested some years ago.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical Features and Prognosis of Adult Polycystic Kidney Disease

Gonzalo¹,

Rivera²,

Quereda³

et al. 1990

Am J Nephrol

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“…In particular, it is incorrect to state that the disease invar iably leads to end-stage renal failure (their first sentence). Several studies have shown that large numbers of af fected patients may live to 70 years or more without renal impairment [2][3][4] and we can confirm this from our own genetic register of the condition.…”

supporting

confidence: 76%

Genetic Counselling in Adult Polycystic Kidney Disease

Coles¹,

Davis²

1991

Nephron

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“…Von Recklinghausen's neurofibromatosis and adult polycystic disease of the kidneys (APDK) are both heredofamilial disorders (Preiser and Davenport, 1918;Dalgaard, 1971) although sporadic cases also occur (Wander and Dsgupta, 1977;Hatfield and Pfister, 1972). Both the conditions are known to occur in association with a number of other hereditary disorders (Dalgaard, 1971; Koch, 1977).…”

Section: Introductionmentioning

confidence: 99%