Clinical Features and Prognosis of Adult Polycystic Kidney Disease

Gonzalo, Ana; Rivera, Maite; Quereda, C.; Ortuño, J

doi:10.1159/000168171

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Mean age at renal function loss was 47.9 years, similar to data reported by others for Spanish patients (11). Another study showed that mean patient age at the beginning of dialysis was 52.5 years among males and 58.1 years among females for German patients (12), suggesting a poorer outcome in male patients.…”

Section: Discussionsupporting

confidence: 83%

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Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease

Romão

Neto

Teixeira

et al. 2006

Braz J Med Biol Res

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The objective of the present study was to determine the frequency of the most common clinical features in patients with autosomal dominant polycystic kidney disease in a sample of the Brazilian population. The medical records of 92 patients with autosomal dominant polycystic kidney disease attended during the period from 1985 to 2003 were reviewed. The following data were recorded: age at diagnosis, gender, associated clinical manifestations, occurrence of stroke, age at loss of renal function (beginning of dialysis), and presence of a family history. The involvement of abdominal viscera was investigated by ultrasonography. Intracranial alterations were prospectively investigated by magnetic resonance angiography in 42 asymptomatic patients, and complemented with digital subtraction arteriography when indicated. Mean age at diagnosis was 35.1 ± 14.9 years, and mean serum creatinine at referral was 2.4 ± 2.8 mg/dL. The most frequent clinical manifestations during the disease were arterial hypertension (63.3%), lumbar pain (55.4%), an abdominal mass (47.8%), and urinary infection (35.8%). Loss of renal function occurred in 27 patients (mean age: 45.4 ± 9.5 years). The liver was the second organ most frequently affected (39.1%). Stroke occurred in 7.6% of the patients. Asymptomatic intracranial aneurysm was detected in 3 patients and arachnoid cysts in 3 other patients. In conclusion, the most common clinical features were lumbar pain, arterial hypertension, abdominal mass, and urinary infection, and the most serious complications were chronic renal failure and stroke. Both intracranial aneurysms and arachnoid cysts occurred in asymptomatic patients at a frequency of 7.14%.

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Section: Discussionsupporting

confidence: 83%

“…The study showed a higher prevalence (63.0%) of the condition among women. Another study reported a 65.5% prevalence of ADPKD in American women (10), similar to this sample, while other investigators studying a Spanish population did not find any difference in ADPKD prevalence between genders (11).…”

Section: Discussionsupporting

confidence: 82%

Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease

Romão

Neto

Teixeira

et al. 2006

Braz J Med Biol Res

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“…The reason is presumably that the patients who survive over 70 years have a better renal function than those who died before 70. In table 4, data regarding the prognosis for patients with ADPKD in several countries [4, 13, 14, 15, 16]are tabulated and compared with those of the present study. It is intriguing that relatively similar results were obtained although different methods were used in the previous [4, 14, 15, 16]and present studies.…”

Section: Discussionmentioning

confidence: 99%

“…In table 4, data regarding the prognosis for patients with ADPKD in several countries [4, 13, 14, 15, 16]are tabulated and compared with those of the present study. It is intriguing that relatively similar results were obtained although different methods were used in the previous [4, 14, 15, 16]and present studies. The prognosis generally improved in the later studies, probably due to better medical management, early diagnosis, diagnosis of patients with mild phenotype and other improvements in environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Renal Prognosis of Diagnosed Autosomal Dominant Polycystic Kidney Disease in Japan

Higashihara

Nutahara²,

Kojima³

et al. 1998

Nephron

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The prevalence and renal prognosis of diagnosed autosomal dominant polycystic kidney disease (ADPKD) in Japan were estimated. Hospital-based nationwide surveys were conducted in 1995. The number of ADPKD patients who visited hospitals but were not on chronic dialysis was estimated to be 10,000 (95% confidence interval: 8,200–11,900) and that of ADPKD patients on dialysis was 4,590, yielding a prevalence of ADPKD of 117 per million population at the end of 1994 (95% confidence interval: 102–132). The prevalence increased with age and reached a peak value of 261 per million population at the age group of 55–59 years. The rate of end-stage renal disease among living patients was calculated based on the assumption that the prevalence of ADPKD in the population under the age of 55 years was 261 per million population. The rate of end-stage renal disease increased with the progression of the patients’ age, reaching 49% at the age of 65–69 years and declining thereafter. Conclusion: The hospital-based prevalence of ADPKD is lower than the autopsy-based prevalence, suggesting that a fairly large number of these patients do not receive medical care in their lifetime. The probability of end-stage renal disease is at most 50% among ADPKD patients who visit a hospital.

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“…An early and high incidence of hypertension has been documented in autosomal dominant polycystic kidney dis ease (ADPKD) even in the absence of renal impairment [1][2][3][4][5][6]. In addition, hypertension is a well-accepted risk factor that accelerates loss of renal function.…”

Section: Introductionmentioning

confidence: 99%

Shape of the Relationship between Hypertension and the Rate of Progression of Renal Failure in Autosomal Dominant Polycystic Kidney Disease

Gonzalo

Gallego

Rivera

et al. 1992

Nephron

Self Cite

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The effect of hypertension on the rate of progression of renal failure was analyzed in 26 patients with autosomal dominant polycystic kidney disease relating the slopes of progression (linear regression of the reciprocal serum creatinine on time) with the average mean arterial pressure, systolic and diastolic pressure, derived over the entire follow-up period for each patient. Hypertension was found in 19 of the 26 patients. Using simple linear regression, there was no significant correlation between the two variables in any case. Using polynomial regression (quadratic and cubic), this relationship fits a sigmoid (for diastolic pressure) or a negative parabolic curve (for mean arterial pressure and systolic pressure); i.e. the lowest and the highest values of mean arterial pressure and systolic pressure were associated with faster rates of progression. Thus, an appropriate model to study this relationship is not the linear but the polynomial regression.

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Clinical Features and Prognosis of Adult Polycystic Kidney Disease

Cited by 15 publications

References 7 publications

Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease

Renal and extrarenal manifestations of autosomal dominant polycystic kidney disease

Prevalence and Renal Prognosis of Diagnosed Autosomal Dominant Polycystic Kidney Disease in Japan

Shape of the Relationship between Hypertension and the Rate of Progression of Renal Failure in Autosomal Dominant Polycystic Kidney Disease

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