Adult Neuroblastoma-Case  Report and Literature Review

Godkhindi, Vishwapriya M; Basade, Maheboob; Khan, Kamran Ahmed; Thorat, Kiran

doi:10.7860/jcdr/2016/20237.9080

Cited by 5 publications

(7 citation statements)

References 15 publications

(2 reference statements)

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“…Thus, adult neuroblastoma is considered to have a poor prognosis because the standard treatment has not been established and the current situation demands referring to the guidelines for children for treatment. For this reason, in recent years, cases in which ICE therapy was effective for children have been reported [15] and as expected, cases of usage of ICE therapy in adults have been reported [1,16] as in our case. However, adults, as in the case of our patient, may refuse chemotherapy due to the serious side effects of chemotherapy such as nausea and vomiting; therefore, treatment may not be performed adequately in line with the guidelines, which seems to be a problem.…”

Section: Figure 2bsupporting

confidence: 85%

“…Regarding prognosis, the five-year survival rate of patients with stages III and IV disease is 28%, and the median value when metastasis is recognized is reported to be 1.6% [1]. As shown in (Table 2) the survival rate of patients with stages III and IV disease is similarly low in cases of primary adult retroperitoneal neuroblastoma in Japan.…”

Section: Figure 2bmentioning

confidence: 97%

“…In addition, the pathology, treatment, and prognosis of adult neuroblastoma are unclear. The incidence of adult neuroblastoma has been reported as being one in one billion people [1], and the age of onset has also been widely reported (16-82 years) [1][2][3]. The retro peritoneum is reported to be the most frequent site of occurrence, while the frequency of adrenal gland nucleus is less than that found in children [4][5][6].…”

Section: Figure 2bmentioning

confidence: 99%

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A Case of Retroperitoneal Primary Neuroblastoma that Developed in Adulthood

Watanabe¹,

Hara²,

Kondo³

et al. 2018

J Tum Res Rep

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Neuroblastoma is a solid malignant tumor found in young children period, but it may also develop in adulthood. Adult neuroblastoma is rare in Japan (incidence of at least 1/100 million). Here, we report on an adult with retroperitoneal primary neuroblastoma. A 32-year-old woman presented with a chief complaint of abdominal tumor diagnosed as neuroblastoma on needle biopsy. The tumor markers for neuroblastoma were 32.6 ng/ml for neuron specific enolase, 30.1 μg/mg Cr for urine vanillylmandelic acid and 42.3 μg/mg Cr for urine homovanillic acid. Imaging showed metastasis to the mediastinal lymph nodes, but bone metastases were not found. The International Neuroblastoma Risk Group Staging System classification for this neuroblastoma was stage M. The tumor involved the left renal artery and aorta. The case was positive for image defined risk factors. Therefore, the patient received three courses of cyclophosphamide, pirarubicin, vincristine, and cisplatin. Tumor shrinkage was noted. We recommended continued chemotherapy, and bone marrow transplantation, but the patient refused further chemotherapy due to the serious side effects of chemotherapy. Tumor extirpation was judged possible by resection of the left renal tumor using a retroperitoneal mirror in combination. The excised tumor was more ganglion-like than at biopsy, and a stroma-rich portion was recognized, which was thought to be maturation due to chemotherapy. MYCN gene amplification was absent. Postoperatively, radiotherapy of the tumor bed and mediastinal lymph nodes was performed and the patient was followed-up. Many adults refuse chemotherapy, which makes sufficient treatment difficult. In adults, even when MYCN gene amplification is not allowed, sufficient observation is necessary since prognosis is the poor.

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Section: Figure 2bsupporting

confidence: 85%

Section: Figure 2bmentioning

confidence: 97%

Section: Figure 2bmentioning

confidence: 99%

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A Case of Retroperitoneal Primary Neuroblastoma that Developed in Adulthood

Watanabe¹,

Hara²,

Kondo³

et al. 2018

J Tum Res Rep

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“…Neuroblastic tumors are predominantly pediatric burdened neural crest tumors that are rarely seen in the adult population. Neuroblastoma, a subtype of neuroblastic tumor, accounts for 7% of pediatric malignancies but is responsible for an incidence of only 1 in 10 million adults per year [1] . Ganglioneuroblastoma is a histologically different entity that demonstrates less malignant potential than neuroblastoma but part of the greater family of neuroblastic tumors [2] .…”

Section: Introductionmentioning

confidence: 99%

Adult-onset ganglioneuroblastoma of the posterior mediastinum with osseous metastasis

Mousa¹,

Shokouh-Amiri²,

Shah

et al. 2020

Radiology Case Reports

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Ganglioneuroblastomas are a member of the neuroblastic family of tumors most commonly seen in children but they may also occur in adults. Ganglioneuroblastomas have metastatic potential and, like other neuroblastic tumors, osseous metastasis is possible. Imaging features of ganglioneuroblastomas tend to be variable. We describe a case of an adult female who developed a ganglioneuroblastoma of the posterior mediastinum that metastasized to the thoracolumbar spine, highlighting rarely documented osseous metastasis.

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“…[2] Neuroblastoma occurs more commonly in children, but is extremely rare in adults, especially in the retroperitoneum and its total incidence according to foreign studies is 1/10 million. [3,4]…”

Section: Introductionmentioning

confidence: 99%

Adult neuroblastoma in the retroperitoneum

Dai

Sun

et al. 2018

Medicine

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Rationale:Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is found in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system. Huge neuroblastoma in the retroperitoneum, especially adult involvement is extremely rare.Patient concerns:A 20-year-old female patient with complaints of left abdominal discomfort for 1 week was reported.Diagnosis:Multi-detector computed tomography (MD-CT) of the abdomen revealed a huge enhanced mass in the retroperitoneum. Histopathological findings showed neuroblastoma and immunohistochemical results were as follows: actin(–), CD34(–), CD99(–), CK(–), CgA(+), desmin(–), EMA(–), Ki-67(+, approximately 1%), NSE(+), S-100(+), Syn(+), and vimentin(–).Interventions:We performed a total surgical resection. The CYVADIC (cyclophosphamide, vincristine, adriamycin, and dimethyl triazeno imidazole carboxamide) and James (cyclophosphamide and vincristine) regimens had been administered to this patient.Outcomes:Postoperatively, the patient's symptoms were partially relieved and the patient experienced recurrence after 3 months. The patient did not respond to treatment and died 6 months after the operation.Lessons:Besides surgical resection, the treatment also included chemotherapy and radiotherapy. However, the optimal treatment remains controversial. Therefore, we should exert all our energies on the exploration of etiology and targeted drugs for this disease.

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Adult Neuroblastoma-Case Report and Literature Review

Cited by 5 publications

References 15 publications

A Case of Retroperitoneal Primary Neuroblastoma that Developed in Adulthood

A Case of Retroperitoneal Primary Neuroblastoma that Developed in Adulthood

Adult-onset ganglioneuroblastoma of the posterior mediastinum with osseous metastasis

Adult neuroblastoma in the retroperitoneum

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