Adult mental health outcomes of adolescent depression: A systematic review

Johnson, Dylan; Dupuis, Gabrielle; Piché, Justin; Clayborne, Zahra M.; Colman, Ian

doi:10.1002/da.22777

Cited by 312 publications

(227 citation statements)

References 74 publications

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…Body dissatisfaction has been associated with eating disorders e.g. bulimia and anorexia [6], and depressive symptoms have been associated with academic problems and failure, substance abuse, self-harming behaviors and suicide [7] and depression in adulthood [8]. Approximately 40% of adolescent females and 23% of adolescent males are dissatisfied with their bodies [9]; and the prevalence of major depressive episodes within the past year is 20.0% among adolescent females and 6.8% among adolescent males [10].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal bidirectional relations between body dissatisfaction and depressive symptoms among Black adolescents: A cross-lagged panel analysis

et al. 2020

View full text Add to dashboard Cite

ObjectiveTo assess the variation in body dissatisfaction and depressive symptoms by weight status and the bi-directional relations between body dissatisfaction and depressive symptoms by weight status among Black adolescents. MethodsA sample of 153 Black adolescents aged 12-13 years, either overweight/obese (n = 57, 37%) or healthy weight (n = 96, 63%), were recruited and evaluated three times over two years (T1, T2 and T3). Measured weight and height were converted to age and sex-specific BMI z-score; body dissatisfaction was measured with silhouettes, and depressive symptoms were measured with the Beck Depression Inventory (BDI-I). Bidirectional relations were assessed with cross-lagged panel analyses, accounting for stability over time and contemporary correlations. ResultsBody dissatisfaction was higher among the overweight/obese group than the healthy weight group. No significant differences were found for depressive symptoms by weight status. Among the overweight/obese group, there were bidirectional relations: antecedent body dissatisfaction predicted subsequent depressive symptoms (T1-T2: β = 0.42, SE = 0.11, p<0.001; T2-T3: β = 0.36, SE = 0.09, p<0.001) and antecedent depressive symptoms predicted subsequent body dissatisfaction (T1-T2: β = 0.25, SE = 0.10, p = 0.012; T2-T3: β = 0.17, SE = 0.08, p = 0.045). Among the healthy weight group, there was no relation in either direction.

show abstract

Section: Introductionmentioning

confidence: 99%

Longitudinal bidirectional relations between body dissatisfaction and depressive symptoms among Black adolescents: A cross-lagged panel analysis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As many as 50% of adolescents self-report clinically significant symptoms of depression (Kessler et al, 2001), and an estimated 8-20% of individuals will have a major depressive disorder before the age of 18 (Johnson et al, 2018). While depression generally declines from the middle adolescence into adulthood (Ge et al, 2001), there is substantial heterogeneity in how depression develops between individuals (Costello et al, 2008;Dekker et al, 2007;Olino et al, 2010).…”

Section: Genetics Rdoc and Trajectories Of Depressionmentioning

confidence: 99%

RDoC Mechanisms of Transdiagnostic Polygenic Risk for Trajectories of Depression: From Early Adolescence to Adulthood

Zhang

2020

Preprint

View full text Add to dashboard Cite

There is substantial heterogeneity in the development of depression across early adolescence into adulthood. Yet, little is known about the risk factors underlying individual differences in the development of depression. For instance, despite the discovery of genetic variants for depression, there is also significant genetic overlap between depression and other mental disorders. Thus, depression may have etiologically complex (i.e., transdiagnostic) origins when accounting for its heterogeneous developmental presentations. This study examined the association between a transdiagnostic polygenic score for psychopathology (p-factor PGS) and depressive trajectories, spanning early adolescence into adulthood, in the National Longitudinal Study of Adolescent to Adult Health. We also examined whether the Research Domains Criteria (RDoC) negative valence (i.e., negative emotionality), positive valence (i.e., novelty seeking), and cognitive systems (i.e., picture vocabulary) could explain how the p-factor PGS eventuates into the various pathways of depressive development. Four trajectories of depression were identified: low depression (78.9%), low increasing (7.3%), high declining (8.2%), and early adult peaked (5.7%). The p-factor PGS was only associated with the trajectory that showed increasing depression over time -low increasing. There was also a specific indirect effect by which the association of p-factor PGS on early adult peaked and high declining depression was partially mediated by negative emotionality, but not by picture vocabulary or novelty seeking.Our findings reinforce the crucial role of development in genetically-informed RDoC models of depression, as there appear to be distinct correlates and risk factors that underlie the various developmental pathways of depression. Clinical implications were also discussed.General Scientific Summary: There are individual differences in how depression symptoms progress over time, but little is known about the risk factors that underlie these various patterns of development. This study suggests that there are distinct correlates and risk factors that underlie the various developmental pathways of depression. We found that transdiagnostic polygenic risks for psychopathology are directly associated with worsening patterns of adolescent to adult depression and indirectly associated with the less severe patterns of depression via negative emotionality.

show abstract

“…Three of five articles reported a link between adolescent depression and adult suicidality. 16 Of course, the potential of studies investigating the exposome goes well beyond psychiatry and neurology. The exposome could help analyse factors that contribute to, among many other chronic ailments, cancer, lung conditions and cardiovascular disease.…”

Section: A Daunting Prospectmentioning

confidence: 99%

The exposome: embrace the complexity

Greener¹

2019

Prog Neurol Psychiatry

View full text Add to dashboard Cite

Links between the microbiome and psychiatric and neurological disease have been the focus of much attention in recent years and may add to our understanding of the complexities of these diseases in tandem with our developing knowledge of the genome's role. However, a third domain ‐ the so‐called exposome ‐ may also need consideration if we are to gain deeper insights into the complex nature of psychiatric and neurological disease.

show abstract

Adult mental health outcomes of adolescent depression: A systematic review

Cited by 312 publications

References 74 publications

Longitudinal bidirectional relations between body dissatisfaction and depressive symptoms among Black adolescents: A cross-lagged panel analysis

Longitudinal bidirectional relations between body dissatisfaction and depressive symptoms among Black adolescents: A cross-lagged panel analysis

RDoC Mechanisms of Transdiagnostic Polygenic Risk for Trajectories of Depression: From Early Adolescence to Adulthood

The exposome: embrace the complexity

Contact Info

Product

Resources

About