Adult Hippocampal Neurogenesis: One Lactate to Rule Them All

Nicola, Raneen; Okun, Eitan

doi:10.1007/s12017-021-08658-y

Cited by 17 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…How exercise leads in neurogenesis and memory improvement has not been clarified yet. Some researchers believe that intensive exercise training, produces lactate (Scandella and Knobloch, 2019;Nicola and Okun, 2021), and then, lactate stimulates neurons and glia cells proliferation (Steiner et al, 2004;Hirase and Shinohara, 2014;El Hayek et al, 2019), particularly in the hippocampus (Ohia-Nwoko et al, 2014;Elahi et al, 2016). Moreover, lactate induces brain derived neurotropic factor (BDNF) expression in the hippocampus, and then BDNF stimulates neurogenesis (El Hayek et al, 2019).…”

Section: Neurogenesismentioning

confidence: 99%

Exercise Training Improves Memory Performance in Older Adults: A Narrative Review of Evidence and Possible Mechanisms

Babaei

Azari

2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: Neurogenesismentioning

confidence: 99%

Exercise Training Improves Memory Performance in Older Adults: A Narrative Review of Evidence and Possible Mechanisms

Babaei

Azari

2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Although hippocampal neurogenesis is crucial in maintaining hippocampus-based cognitive function (29)(30)(31), lactate contributes to maintaining and enhancing its neurogenesis (16,32,33). A previous study reported that i.p.…”

mentioning

confidence: 99%

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Shima

Yoshikawa

Onishi

2022

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Low-carbohydrate and high-protein (LC-HP) diets are acceptable for improving physiological and metabolic parameters. However, the effects of LC-HP diets on the brain are unclear, which depend on glycometabolism for neuronal activity. Since astrocyte-neuron lactate shuttle (ANLS) is an essential pathway for maintaining brain functions, we investigated the changes in hippocampal memory function. In addition, the alteration of lactate transporter constituting ANLS and ANLS-related neurotrophic factors by feeding LC-HP diets was evaluated in healthy mice. C57BL/6 mice were divided into two groups: a group feeding LC-HP diet (24.6% carbohydrate, 57.6% protein, and 17.8% fat as percentages of calories) and a group feeding control diet (58.6% carbohydrate, 24.2% protein, and 17.2% fat as percentages of calories). Here, we found that 4 wk of LC-HP diet feeding suppressed memory function in mice evaluated by Y-maze. Hippocampal mRNA levels of lactate transporters, such as Mct1, Mct4, and Mct2, were unchanged with feeding LC-HP diets; however, LC-HP diets significantly decreased Dcx and Igf-1 receptor mRNA levels in the hippocampus. Bdnf and its related signaling in mice hippocampus exhibited no change by LC-HP diets. Although there was non-influence in the lactate-transport system, LC-HP diets would suppress hippocampal working memory with dysregulation of neuroplasticity. The current data propose the importance of food choices for maintaining hippocampal health.

show abstract

“…According to the astrocyte-neuron lactate shuttle hypothesis, astrocytes promote glucose consumption or glycogen breakdown to enhance lactate production, which is then transported to neurons via MCT to support neuronal activity. In AD, the astrocyte’s ability to take up glucose is diminished and lactate production is reduced, which affects the subsequent neuronal regeneration process ( Nicola and Okun, 2021 ). In the course of neuroinflammation, MCT1 dysfunction and changes in lactate levels affect the pro-inflammatory response of microglia.…”

Section: Key Mechanisms Of Altered Ahn In Alzheimer’s Diseasementioning

confidence: 99%

Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease

et al. 2023

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD.

show abstract

Adult Hippocampal Neurogenesis: One Lactate to Rule Them All

Cited by 17 publications

References 21 publications

Exercise Training Improves Memory Performance in Older Adults: A Narrative Review of Evidence and Possible Mechanisms

Exercise Training Improves Memory Performance in Older Adults: A Narrative Review of Evidence and Possible Mechanisms

Low-Carbohydrate and High-Protein Diet Suppresses Working Memory Function in Healthy Mice

Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease

Contact Info

Product

Resources

About