Adult Cancer Pain

Swarm, Robert A.; Abernethy, Amy Pickar; Anghelescu, Doralina L.; Benedetti, Costantino; Blinderman, Craig D.; Boston, Barry; Cleeland, Charles S.; Coyle, Nessa; deLeon-Casasola, Oscar A.; Eilers, June; Ferrell, Betty; Janjan, Nora A.; Karver, Sloan Beth; Lévy, Michaël; Lynch, Maureen; Moryl, Natalie; Murphy, Barbara A.; Nesbit, Suzanne; Oakes, Landon; Obbens, Eugenie A.M.T.; Paice, Judith A.; Rabow, Michael W.; Syrjala, Karen L.; Urba, Susan G.; Weinstein, Sharon M.

doi:10.6004/jnccn.2010.0076

Cited by 238 publications

(171 citation statements)

References 151 publications

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“…Cancer-related pain is arguably the physical ailment most feared by cancer patients (24,25). Yet while clinical trials designed to assess the efficacy of new therapies for cancer include a variety of measures to assess a patient's physical response to therapy, these trials often do not include pain as either a primary or secondary outcome.…”

Section: Conclusion and Next Stepsmentioning

confidence: 99%

Integrating Pain Metrics into Oncology Clinical Trials

Cleeland

O’Mara

Zagari

et al. 2011

Clinical Cancer Research

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Cancer-related pain is highly prevalent and often severe, and as a result is often one of the defining experiences for patients with malignancy. Patients and patients' families almost always live with the ever-present reality that cancer treatment and progression may be accompanied by pain. For patients nearing the end of life, most fear that their final days will be spent living with the terrible effects of the disease, the most important of which is pain. Despite this, there is far less systematic research on the mechanisms of cancer-related pain or on the development of new agents to reduce or eliminate pain in cancer patients compared with research to combat the disease itself. Further, even when the focus of research is treatment of the tumor, the effects of anticancer treatments on pain are often underreported in publications and other forums. To illustrate the relative drought in the cancer pain control area, there have been no new drugs approved for cancer-related pain in recent years. A number of methodologic and logistical challenges that hinder the ability to assess pain response in clinical trials are discussed in this article. Possible ways to address these challenges are also discussed.

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Section: Conclusion and Next Stepsmentioning

confidence: 99%

Integrating Pain Metrics into Oncology Clinical Trials

Cleeland

O’Mara

Zagari

et al. 2011

Clinical Cancer Research

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“…Fentanyl patch 25 mcg was calculated to equivalent intravenous pethidine 150 mg by NCCN guideline. 7 The LS surgeries were performed under general anesthesia and supine position with right sided tilting. The surgeon stood on the patient's right side, with the first assistant on the patient's left side, and the camera assistant stood to the surgeon's right.…”

Section: Methodsmentioning

confidence: 99%

Does Laparoscopic Splenectomy have the Advantage on Postoperative Pain?

Shim

Yun

Seo

2015

J Minim Invasive Surg

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Results: For the two groups of patients, the following were similar: estimated blood loss, transfusion, operative time, duration of patient-controlled analgesia, and the additional administration of painkillers. In the laparoscopic splenectomy group, the postoperative hospital stay (7.9±1.6 days versus 5.9±1.4 days, p=0.002) and the diet start time (2.7±0.3 days versus 1.8±0.8 days, p=0.003) were significantly shorter. No significant difference in postoperative pain was observed between the two groups. Conclusion:In this study, there was no benefit for postoperative pain in the LS group. However, the laparoscopic splenectomy has several benefits, including a shorter postoperative hospital stay and an earlier diet start time; in addition, it is feasible and safe.

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“…Nociceptive cancer pain is further classified into two pain types: bone pain and visceral pain [46]. Current National Comprehensive Cancer Network (NCCN) recommendations for the treatment of adult cancer pain secondary to cancer focus on a multifaceted approach including the use of analgesic therapy in conjunction with management of symptom clusters [47]. Multidisciplinary pain management incorporating interventional strategies such a RT, neurosurgical procedures, nerve block/neurolysis and regional infusions serve as important components for treatment [47].…”

Section: Neurolysis With Focus On Celiac Neurolysis For Pain Controlmentioning

confidence: 99%

“…Current National Comprehensive Cancer Network (NCCN) recommendations for the treatment of adult cancer pain secondary to cancer focus on a multifaceted approach including the use of analgesic therapy in conjunction with management of symptom clusters [47]. Multidisciplinary pain management incorporating interventional strategies such a RT, neurosurgical procedures, nerve block/neurolysis and regional infusions serve as important components for treatment [47]. Although very helpful in palliative treatment and improvement of QOL, many treatments have potentially limiting side effects and toxicities (analgesics and chemotherapeutics), dosage limitations (RT) and contraindications (poor candidacy for, or refusal of, surgical and RT) [48].…”

Section: Neurolysis With Focus On Celiac Neurolysis For Pain Controlmentioning

confidence: 99%

The role of interventional oncology in the palliative care of cancer patients

Hussaini

Kang

et al. 2016

Expert Review of Quality of Life in Cancer Care

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Interventional oncologists have expertise in delivery of state of the art, minimally invasive, imageguided procedures. As such, interventional oncologists are well-suited to provide palliative options for cancer patients, who often have complex comorbidities precluding them from more invasive options. The broad spectrum of procedures developed into clinical practice highlight the integral role of interventional oncology in the palliation of cancer patients. This review will focus on several of the more common procedures performed by interventional oncologists to provide symptomatic relief: 1. Tunneled peritoneal or pleural catheter placement for fluid drainage; Peritoneovenous shunt placement for fluid drainage; 2. Ablation with focus on metastatic bone ablation for pain control; 3. Neurolysis with focus on celiac neurolysis for pain control; 4. Decompressive gastrostomies or cecostomies for gastric and bowel obstruction; 5. Transarterial embolization for uncontrolled hemorrhage. A description of each procedure and its relative efficacy in providing palliation will be summarized. ARTICLE HISTORY

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Adult Cancer Pain

Cited by 238 publications

References 151 publications

Integrating Pain Metrics into Oncology Clinical Trials

Integrating Pain Metrics into Oncology Clinical Trials

Does Laparoscopic Splenectomy have the Advantage on Postoperative Pain?

The role of interventional oncology in the palliative care of cancer patients

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