Adsorptive stripping voltammetric quantification of the antipsychotic drug clozapine in bulk form, pharmaceutical formulation and human serum at a mercury electrode

Аналитические Методы Определения Содержания Атипичных Нейролептиков (Обзор)

“…Ýëåêðî-àíàëèòè÷åñêèå ìåòîäû (ïîòåíöèîìåòðèÿ, âîëüòàìïåðîìåòðèÿ, ïîëÿðîãðàôèÿ ) ïðèìåíÿþòñÿ â íàñòîÿùèé ìîìåíò äîñòàòî÷íî ðåäêî, õîòÿ íåêîòîðûå ïî ñåëåêòèâíîñòè è òî÷íîñòè íå óñòóïàþò õðîìàòîãðà-ôè÷åñêèì [34]. Îãðàíè÷åíèÿ ñâÿçàíû ñ òîêñè÷íîñòüþ íåêîòîðûõ èç íèõ (ïðèìåíåíèå ðòóòíûõ êàïåëüíûõ ýëåêòðîäîâ), òðóäîåìêîñòüþ àíàëèòè÷åñêèõ ïðîöåäóð, îãðàíè÷åííîñòüþ ïðèìåíåíèÿ èìåííî â áèîëîãè÷åñêèõ ìàòðèöàõ.…”

Voltammetric Determination of Clozapine in Pharmaceutical Formulations and Biological Fluids Using an In Situ Surfactant‐Modified Carbon Ionic Liquid Electrode

“…To our knowledge, previous methods for determination of CLZ cannot be used if the serum has not been separated from its proteins and centrifugal separation of the precipitated proteins by methanol or sodium tungstate was necessary prior to analysis [17,18] (Table 1 Column 6). When using the ISS-CILE it was possible to determine CLZ in spiked human serum and plasma with no previous separation of blood proteins, pretreatment, time-consuming extraction or evaporation steps.…”

“…The limit of the quantification (LOQ) value was 6.95 10 À10 mol L À1 with RSD = 2.3 %. Table 1 summarizes the results of the proposed ISS-CILE and comprises the response characteristics of this modified electrode with those of electrodes reported in the literature by other researchers [16][17][18].…”

Spectral, Electrochemical and Molecular Modeling Studies of Some 3 (2 Hydroxy benzalhydrazino‐4‐thiazolyl)coumarins

“…In the pH range, 1-6, the compounds exhibit a single irreversible reduction peak with an n value of 2. The plot of E p vs. pH, in this range is used to evaluate the number of H + ions involved in the reduction process 17,18 . giving two successive reduction current peaks 19 .…”