Adsorptive membranes for bilirubin removal

Adsorption of bilirubin with polylysine carrying chitosan-coated nylon affinity membranes

“…The specific bilirubin adsorption increased with the increasing of bilirubin initial concentration at the given concentration range. The bilirubin adsorption capacities of the PLL-CS affinity membranes were greater than the literature data [12][13][14].…”

“…However, HEC-coated nylon membrane can only provide hydroxyl groups, and the content of reactive groups was still low. Lately Avramescu et al employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin retention [14]. BSA as model ligand was coupled on the membrane by trichloro-s-triazine (sTT) activation.…”

Fractionation of β‐Lactoglobulin from whey by mixed matrix membrane ion exchange chromatography

“…The concept is quite simple and it is easy to prepare such mixed matrix membranes while still giving a performance that is competitive with current chromatographic membranes. Wessling et al prepared MMM adsorbers using an ethylene vinyl alcohol (EVAL) base membrane with several types of lewatit cation and anion exchange resins and successfully applied these to the separation of bovine serum albumin (BSA), lysozyme and bilirubin (Avramescu et al, 2003b(Avramescu et al, , 2004Saiful et al, 2006). Although this type of ion exchange MMM adsorber was first reported in 2003, little attention has been given to it for industrial applications.…”

Studies on preparing and adsorption property of grafting terpolymer microbeads of PEI-GMA/AM/MBA for bilirubin

“…The free bilirubin is a lipophilic endotoxin, and under normal physiological conditions, it is transported to liver by albumin for conjugation and subsequent excretion [1,2]. However, in certain pathological conditions such as jaundice, the amount of unconjugated bilirubin in blood increases and the elevated bilirubin level interferes with the normal functioning of the cellular machinery and eventually manifests systemic toxicity [1], and further may result in fatal kernicterus [3,4].…”