Adsorptive anodic stripping differential pulse voltammetric determination of CellCept at Fe3O4 nanoparticles decorated multi-walled carbon nanotubes modified glassy carbon electrode

Gholivand, Mohammad Bagher; Solgi, Mohammad

doi:10.1016/j.ab.2016.12.019

Cited by 13 publications

(1 citation statement)

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“…In the Nyquist plot, the diameter of the semicircle at high frequency equals to the electron transfer resistance ( R ct ) and it can be used to describe the interface properties of the electrode. [ 34 ] The Nyquist curve of the PGE had an apparent hemicycle at high frequency region; however, the diameter of the semicircle remarkably decreased with electrochemical pretreatment of PGE. The decrease in the diameter of the semicircle with electrochemical pretreatment shows the increasing conductive ability of P‐PGE.…”

Section: Resultsmentioning

confidence: 99%

Development of a voltammetric method for the determination of rapamycin in pharmaceutical samples at pretreated pencil graphite electrode

Karaboduk

2021

J Chinese Chemical Soc

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This paper describes an electroanalytical method for the determination of rapamycin using a pretreated pencil graphite electrode (P‐PGE) by differential pulse voltammetry. The electrodes were successfully characterized by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscopy, and Fourier transform infrared. The influences of instrumental and chemical parameters were investigated and optimized for the determination of rapamycin. Oxidation peak current obtained for rapamycin at P‐PGE was 10.5 times higher than that obtained for PGE. In pH = 3.0 H3PO4, a well‐defined irreversible anodic peak occurred at 1.07 V, which was attributed to the electro‐oxidation of rapamycin at P‐PGE. Under optimized conditions, the oxidation peak current of rapamycin was linear with its concentration in the range of 0.01–250 μmol/L, and the detection limit was 0.0075 μmol/L (S/N = 3). Also, the P‐PGE exhibited good reproducibility (relative SD [RSD] = 2.17% for 10 electrodes at different times using the same procedure), repeatability (RSD = 2.09% for 10 measurements with same electrode), and stability (95.80% for 10 days). The P‐PGE was simple to prepare and the method was successfully applied for the determination of rapamycin in spiked and real samples. In addition, for comparison, high‐performance liquid chromatographic method with ultraviolet (UV) detector was used for the determination of rapamycin.

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Section: Resultsmentioning

confidence: 99%