An electrochemically polymerized tyrosine film on pencil graphite substrate was found to be an affordable electrochemical sensor for vitamin B9 or folic acid. The electrochemical characteristics of the electrode was studied using cyclic and differential pulse voltammetric techniques in phosphate buffer (pH 7). The surface study of the electrode was carried out by scanning electron microscopy. The sensor showed a linear range from 1μM – 85 μM concentration range by means of differential pulse voltammetry. A good repeatability was obtained for the developed sensor and was utilized for the sustainable application in pharmaceutical tablets.
An electrochemical sensor facilitating the electro oxidation of the immunosuppressant, mycophenolate mofetil (MMF) on pencil graphite electrode (PGE) has been developed. The electrochemical characteristics of the electrode was evaluated by virtue of cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The PGE was characterized by XRD analysis and FE-SEM before and after the electrooxidation of MMF at the electrode. CV of MMF exhibited two irreversible oxidation peaks at about 0.66 V and 0.84 V. In the DPV studies, two linear ranges were observed towards the determination of MMF concentration from 20 nM – 300nM and 300 - 1000 nMin 0.1M phosphate buffer with pH 6. The limit of detection of the sensor was estimated to be 1.80nM. The proposed sensor exhibited acceptable selectivity for quantifying the MMF in pharmaceutical dosage forms and urine samples.
Herein, a novel polymer film modified pencil graphite electrode as an electrochemical sensor for the propranolol hydrochloride (PROP) is reported. A poly nicotinamide modified pencil graphite (Poly-NA-PGE) electrode was used for the electrochemical detection of propranolol hydrochloride using differential pulse voltammetry. The modified electrode was characterized by Scanning Electron Microscopy. Furthermore, the experimental parameters like pH of the supporting electrolyte, concentration of the nicotinamide and polymerisation cycles were optimized. The cyclic voltammetry of propranolol hydrochloride showcased an irreversible oxidation peak at 0.9361V. The sensor showed a linear range from 1μM - 20μM with a correlation co-efficient of 0.99825. The repeatability of the electrode was excellent with an RSD of 3.5%. The sensor was utilized effectually for the determination of propranolol from the commercially available pharmaceutical tablet.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.