Adsorption of levofloxacin on natural zeolite: effects of ammonia nitrogen and humic acid

Chi, Xiaoying; Zeng, Lixuan; Du, Yuejin; Huang, Jiaquan; Kang, Yuan; Luo, Jiwen; Zhang, Qiuyun

doi:10.2166/wst.2022.121

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…The uptake capacity of Ch-W composite increased from 1.89 mg g −1 to 7.42 mg g −1 as the concentration was increased from 1 to 10 mg L −1 . Similar behavior was reported by Chi et al (2022) where the uptake capacity of natural zeolite reached ~ 20 mg g −1 at 20 mg L −1 . Al-Jabari et al ( 2019) stated that the highest levofloxacin removal using chemical Fe 3 O 4 nanoparticles was at pH 6.5, and the contact time was 240 min.…”

Section: The Initial Concentration Effectsupporting

confidence: 88%

“…Antibiotics are not completely digested by the body, and approximately 80% of antibiotics are excreted as unmetabolized compounds in their parent forms (Chi et al 2022). Until now, municipal wastewater treatment plants have not had the potential to completely remove PPCPs and can reach the environmental compartments (Gwenzi et al 2022;Cao et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Mahmoud,

Fawzy

2023

Appl Water Sci

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Chitosan–walnut shells (Ch–W) composite was tested for the removal of levofloxacin from water. Various experimental factors were examined at different contact time intervals. The prepared composite exhibited maximum uptake capacity of 7.43 mg g−1 for levofloxacin with 0.5 g L−1 Ch–W dose at 45 min and pH = 7. Linear and nonlinear isotherm/kinetic models have been investigated, and the pertinency of the models was confirmed by correlation coefficients (R2) and error functions. Consequently, the adsorption of levofloxacin could be more accurately described by the nonlinear pseudo-second-order and Langmuir as well as Temkin models (R2 ˃ 0.98). Optimization modeling of levofloxacin was performed using a central composite design. The independent parameters; initial concentration, pH, and Ch–W dose, were selected while levofloxacin removal was the response. The maximum levofloxacin removal was 75.7% and 94.2% at concentrations of 4 mg L−1 and 2 mg L−1, respectively. Furthermore, 3D surface plots with the interaction effects of the investigated factors are presented. The developed model was reliable for further study and prediction owing to the closeness between the experimental and predicted values. The individual and interacting factors were found to be significant except for “concentration x dose” based on the ANOVA. The models confirmed the experimental results with R2, R2adjusted, and R2predicted values ˃ 0.939. The continuity adsorption cycles were tested for reuse and revealed that the removal of levofloxacin was decreased ~ 23% after six cycles. Hence, the prepared composite has the potential to remove antibiotics from water.

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Section: The Initial Concentration Effectsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Mahmoud,

Fawzy

2023

Appl Water Sci

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“…Various ester prodrugs of LFX including LFX-EHE prevented chelate formation possibly by steric hindrance of the binding site in vitro and in vivo [ 31 , 32 , 33 , 74 ]. In addition to chelate formation in water, quinolones also interact with cationic metal-containing solid materials by physicochemical adsorption [ 15 , 29 , 75 , 76 , 77 ]. For example, the reported rate of adsorption of several quinolones (50 µM) onto solid Al(OH) 3 (2.5 mg/mL) was in the following order: norfloxacin (NFX, 72.0%) > enoxacin (ENX, 61.0%) > LFX (48.1%) = OFX, (47.2%).…”

Section: Discussionmentioning

confidence: 99%

Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

et al. 2023

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Laboratory rabbits are fed foods rich with cationic metals, and while fasting cannot empty gastric contents because of their coprophagic habits. This implies that, in rabbits, the oral bioavailability of chelating drugs could be modulated by the slow gastric emptying rates and the interaction (chelation, adsorption) with gastric metals. In the present study, we tried to develop a rabbit model with low amounts of cationic metals in the stomach for preclinical oral bioavailability studies of chelating drugs. The elimination of gastric metals was achieved by preventing food intake and coprophagy and administering a low concentration of EDTA 2Na solution one day before experiments. Control rabbits were fasted but coprophagy was not prevented. The efficacy of rabbits treated with EDTA 2Na was evaluated by comparing the gastric contents, gastric metal contents and gastric pH between EDTA-treated and control rabbits. The treatment with more than 10 mL of 1 mg/mL EDTA 2Na solution decreased the amounts of gastric contents, cationic metals and gastric pH, without causing mucosal damage. The absolute oral bioavailabilities (mean values) of levofloxacin (LFX), ciprofloxacin (CFX) and tetracycline hydrochloride (TC), chelating antibiotics, were significantly higher in EDTA-treated rabbits than those in control rabbits as follows: 119.0 vs. 87.2%, 9.37 vs. 13.7%, and 4.90 vs. 2.59%, respectively. The oral bioavailabilities of these drugs were significantly decreased when Al(OH)3 was administered concomitantly in both control and EDTA-treated rabbits. In contrast, the absolute oral bioavailabilities of ethoxycarbonyl 1-ethyl hemiacetal ester (EHE) prodrugs of LFX and CFX (LFX-EHE, CFX-EHE), which are non-chelating prodrugs at least in in vitro condition, were comparable between control and EDTA-treated rabbits irrespective of the presence of Al(OH)3, although some variation was observed among rabbits. The oral bioavailabilities of LFX and CFX from their EHE prodrugs were comparable with LFX and CFX alone, respectively, even in the presence of Al(OH)3. In conclusion, LFX, CFX and TC exhibited higher oral bioavailabilities in EDTA-treated rabbits than in control rabbits, indicating that the oral bioavailabilities of these chelating drugs are reduced in untreated rabbits. In conclusion, EDTA-treated rabbits were found to exhibit low gastric contents including metals and low gastric pH, without causing mucosal damage. Ester prodrug of CFX was effective in preventing chelate formation with Al(OH)3 in vitro and in vivo, as well as in the case of ester prodrugs of LFX. EDTA-treated rabbits are expected to provide great advantages in preclinical oral bioavailability studies of various drugs and dosage formulations. However, a marked interspecies difference was still observed in the oral bioavailability of CFX and TC between EDTA-treated rabbits and humans, possibly due to the contribution of adsorptive interaction in rabbits. Further study is necessary to seek out the usefulness of the EDTA-treated rabbit with less gastric contents and metals as an experimental animal.

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“…The significant heterogeneity and structural complexity of HAs, attributed to diverse sources and ecological systems, pose challenges to research on HAs [34]. Studies have demonstrated the fundamental importance of isolating and purifying HAs for their characterization and utilization.…”

Section: Ha Fractionation 221 Methods Of Ha Fractionationmentioning

confidence: 99%

Exploring Humic Acid as an Efficient and Selective Adsorbent for Lead Removal in Multi-Metal Coexistence Systems: A Review

Xue,

Hu,

Wan

et al. 2024

Separations

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Water pollution poses a global threat to human health, particularly in terms of ensuring a safe supply of drinking water. The accumulation of heavy metals from various water sources is increasing, driving the search for effective and environmentally friendly approaches and materials for metal removal. This review investigates the selective adsorption of Pb2+ by humic acid (HA) in a multi-metal coexistence solution. The focus is on discussing approaches to the structural identification of HA, highlighting that separation techniques are an effective method to reduce its heterogeneity. Starting from the key structural units of HA, the study reveals the interaction between HA and heavy metals. Approaches to enhance Pb2+ selective adsorption are explored, proposing that introducing activating groups, Ca ion exchange, and optimizing pore structures are effective approaches for improving lead ion selective adsorption. Ca2+ activation is suggested as a future research direction for lead-selective adsorption. Additionally, attaining lead selective adsorption through pH regulation’s significance is emphasized. This research contributes to a fundamental understanding of HA’s role as a selective lead adsorbent while offering practical implications for developing environmentally friendly adsorbent materials. The results aim to advance knowledge in environmental science and water treatment.

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Adsorption of levofloxacin on natural zeolite: effects of ammonia nitrogen and humic acid

Cited by 8 publications

References 41 publications

Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Decontamination of levofloxacin from water using a novel chitosan–walnut shells composite: linear, nonlinear, and optimization modeling

Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

Exploring Humic Acid as an Efficient and Selective Adsorbent for Lead Removal in Multi-Metal Coexistence Systems: A Review

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