Adsorption of Endocrine Disruptors and Related Compounds Using Natural Polymer Composite Fibers Formed by Polyion Complexes

Takahashi, Yae; Ohkawa, Kousaku; Andô, Masataka; Yamada, Masashi; Yamamoto, Hiroyuki

doi:10.1002/1439-2054(20011201)286:12<733::aid-mame733>3.0.co;2-i

Cited by 5 publications

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References 11 publications

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“…Here, we consider the incorporation of the extracted human hair proteins into the polysaccharide hybrid fiber matrix, by means of the watery hybridization spinning. A set of the counter‐charged polysaccharides, the anionic gellan and the cationic chitosan, were chosen because of the following reasons: (i) gellan and chitosan are available in a large quantity for mass production, (ii) the gellan‐chitosan hybrid fiber exhibited a practical tensile strength,29 (iii) the gellan‐chitosan hybrid fiber can be spun at the relatively low solution concentrations ranging from 0.75 to 1.0 wt.‐%,30 and this allows the human hair proteins to be incorporated as the most major component (above 7 wt.‐% or more) in the hybrid fiber matrix, (iv) chitosan and gellan are polysaccharide, so that, by use of proteases, only the biodegradability of the incorporated human hair proteins can be selectively evaluated, and (v) the gellan‐chitosan hybrid fiber is actually biodegraded by environmental microorganisms,31 implying that the human hair protein‐gellan‐chitosan hybrid fiber can be developed not only as the biomedical but also the environmental engineering materials 32…”

Section: Introductionmentioning

confidence: 99%

A Novel Human Hair Protein Fiber Prepared by Watery Hybridization Spinning

Hirao¹,

Ohkawa²,

Yamamoto³

et al. 2005

Macro Materials & Eng

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IntroductionMany excellent fiber materials occur in nature. Among these materials, silk and wool are two of the strongest animal fibers in their tensile properties. Natural fibers are important materials not only for the cultures of the human race since the ancient times but also for the present technologies and industries. Natural fibrous polymers, for example, animal hair keratin, silk fibroin, tendon collagen, muscle myosin, and cotton cellulose, have attracted researchers in the interdisciplinary fields of investigations, because of their well-designed material performances and Summary: A novel human hair protein hybrid fiber was developed by combining (i) the high-efficiency extraction technique for preparing human hair proteins and (ii) the watery hybridization spinning method using gellan and chitosan. The resulting human hair protein-gellan-chitosan hybrid fibers are conveniently produced by simply mixing the 7-35 wt.-% human hair protein-1.0 wt.-% gellan aqueous solution and the 1.0 wt.-% chitosan-0.15 M acetic acid solution at 50 8C, followed by pulling out to spin the human hair protein-gellan-chitosan ternary complex thus formed at the aqueous solution interface. By use of this simple procedure and ambient spinning condition, the human hair proteins were successfully incorporated into the fiber matrix of gellanchitosan, without any denaturation and degradation. The hybrid fiber can also be recognized as a new type of the regenerated human hair keratin fiber, because of its high purity and content of human hair keratin types I and II. Mechanical strength of the human hair protein-gellanchitosan fiber varies from 108 to 153 MPa, depending on the contents of the human hair proteins. SEM observation revealed that the incorporated human hair proteins were found as the particles (1-10 mm) on the fiber surface. The type I and II keratins in the fiber matrices were rapidly biodegraded by chymotrypsin within 30 min, and the digested fragments slowly released from the fiber matrices. Thus, the human hair hybrid fiber is a very promising material to have a broad spectrum of applications as the engineering fibers, particularly for the medical uses, because the human hair proteins are easily available, biocompatible, and bioresorbable materials.Gellan-chitosan hybrid fiber (a), human hair protein-gellanchitosan hybrid fiber (b). 165functions based on the evolutional conservation, which are full of the interplay between the basic science and applied technologies. [1][2][3] Particularly, the polymer chemistry involved in the wool [4][5][6] and silk [7,8] spinning processes has been of the central interests in both biopolymer science and fiber industries for a prolonged period and also at the present time.In the present study, we attempted to create a novel material science associated with the keratin, a major component of the animal hairs, and focused on the human hairs as the easily available and low-cost keratin sources. Recently, we reported the novel extraction method of the human hair proteins. [9] This method,...

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Section: Introductionmentioning

confidence: 99%

A Novel Human Hair Protein Fiber Prepared by Watery Hybridization Spinning

Hirao¹,

Ohkawa²,

Yamamoto³

et al. 2005

Macro Materials & Eng

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Modifications of Proteins and Poly(amino acids) by Enzymatic and Chemical Methods

Ohkawa¹,

Yamamoto²

2002

Biopolymers Online

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Introduction Naturally Occurring Cross‐linked Materials Keratin, Collagen, and Elastin Structural Proteins in Invertebrate Bodies Isopeptide Cross‐linking of Cellular Proteins Enzymes Involved in the Protein Cross‐links Lysyl Oxidase Tyrosinase Transglutaminase Chemical Cross‐linking Bifunctional Cross‐linking Reagents Oxidants Photo‐Induced Cross‐linking – Photodimerization of Polypeptide Side Chain Noncovalent Cross‐linking – Electrostatic Force Interaction Material Science of Cross‐linked Proteins and Poly(amino acids) Cross‐linked Hydrogels Polyion Complex Material Formulations Medical Adhesives Outlook and Perspectives Acknowledgments

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