Adsorption of cis-dichlorodiammineplatinum by nanostructures based on single-domain magnetite

Abstract

Magnetosensitive nanocomposites on the basis of monodomain magnetite Fe 3 O 4 /meso-2,3-dimercaptosuccinic acid, Fe 3 O 4 /c-aminopropyltriethoxysilane, Fe 3 O 4 / polyacrylamide, Fe 3 O 4 /hydroxyapatite were synthesized. Size distribution of magnetite nanoparticles in ensemble and their magnetic properties were studied. It has been shown that the magnetization curve of the liquid containing monodomain magnetite has a form that is characteristic for superparamagnetics, and its calculations in the framework of Langeven's paramagnetism theory match satisfactorily to the experimental results. The highest adsorption parameters were observed for magnetosensitive nanocomposites Fe 3 O 4 / polyacrylamide and Fe 3 O 4 /c-aminopropyltriethoxysilane. Prospects of the studied nanostructures for medicobiological and technical applications as adsorbents of cis-dichlorodiammineplatinum were shown.

Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them

“…Synthesis of initial magnetite, magnetite/hydroxyapatite nanocomposites, their properties and parameters, doxorubicin adsorption calculation technique are described in [11]. In this work, we used Fe 3 O 4 and Fe 3 O 4 /HA samples with the specific surface area S sp *110 and 100 ± 5 % m 2 /g, respectively.…”

“…Biocompatibility of Fe 3 O 4 /HA NC is a known fact [3][4][5][6][7][8][9][10][11]. In this paper, biocompatibility and bioactivity of the produced samples was monitored by their effect on viability of baker's yeast S. cerevisiae cells [11].…”

“…To produce magnetosensitive multifunctional nanocomposites (NC), considerable interest of researchers is drawn by magnetite (Fe 3 O 4 )/hydroxyapatite (HA) nanostructures of core-shell type, characterized with a unique set of physical, chemical, and biological properties, the ability to create on their basis magnetic liquids (ML) containing anticancer remedies for different functional destination, including cytotoxic drug, anthracycline antibiotic doxorubicin (DOX) [6][7][8][9][10][11][12][13][14][15][16][17]. In this regard, the urgent task is to study the characteristics of the processes of adsorptive immobilization of DOX on the surface of Fe 3 O 4 /HA nanocomposites and its release into the saline, which is used to create ML for medical purposes, while maintaining biological activity of the cytotoxic drug.…”

“…Emergence of the said layer is attributed to chemical interaction of a particle with a stabilizing surfactant [19]. In [11,20], it was found that the calculations of magnetization curve for ML based on single-domain Fe 3 O 4 in the framework of Langevin's paramagnetism theory coordinate satisfactorily with the experimental results in assumption that saturation magnetization of magnetite particles depends on their sizes, and from experimentally measured distributions of the nanoparticles in ensemble one can calculate the magnetization curve for ML based on them.…”

“…Therefore, from the above, it can be argued that investigations of the possibility of using approaches applied in [11,20], based on the use of Langevin's paramagnetism theory, for the description of nanocomposites with superparamagnetic cores and complex shell structures of different chemical nature and magnetic liquids based on them, are urgent.…”