Adsorption of bovine serum albumin onto homo- and copolymer latices

Suzawa, Toshiro; Shirahama, Hiroyuki; Fujimoto, Tetsuya

doi:10.1016/0021-9797(82)90049-2

Cited by 84 publications

(29 citation statements)

References 30 publications

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“…36 The amount of serum albumin adsorbed onto the PVAc latex is considerably low, especially at a pH of 5 to 8, indicating its good compatibility with blood. 37 There were no procedural complications, and no thrombus formation on the electrodes of the PVAc catheter. 38 Several studies have shown that PVAc improves blood compatibility of some polymers, thus demonstrating the good blood compatibility of this polymer.…”

Section: Introductionmentioning

confidence: 85%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

127

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The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

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Section: Introductionmentioning

confidence: 85%

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Jannesari¹,

Varshosaz²,

Morshed³

et al. 2011

IJN

127

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“…This result suggests that, for the peptides examined, the increases in the opportunities for hydrogen bonding to the amine groups on the polymer surface has a greater effect on the surface-peptide binding than the electrostatic surface-peptide interactions. We note, however, that the relative influence of electrostatic surface-peptide interactions has been shown to be influenced by the ionic strength of the solution (9,24,26,29). The ionic strength of the 10 mM PBS solution used in these studies (approx.…”

Section: Figmentioning

confidence: 97%

“…However, due to the disadvantages of working with radioisotopes (e.g., the short useful lifetime of the isotope, the need for special facilities to handle the isotope, the possibility of the label altering the surface binding properties of the protein), a variety of alternative approaches have been developed (4). These methods include the use of fluorescently labeled proteins (7,8), colorimetric methods to determine protein concentration (9,10), in situ ellipsometry (11,12), and, more recently, surface plasmon resonance spectroscopy (13,14).…”

mentioning

confidence: 99%

Studies of Peptide Binding to Allyl Amine and Vinyl Acetic Acid-Modified Polymers Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Walker

Qiu

et al. 1999

Analytical Biochemistry

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“…This pH is close to the isoelectric point of BSA, at which molecules 568 form compact structures. 24 Figure 7 shows the results of BSA adsorption on poly(MPC-co-M) microspheres. Figure 8 describes BSA adsorption on a series of microspheres of poly(MPCco-M) and poly(M) at 50mg1-1 of initial concentration of BSA.…”

Section: Bsa Adsorption On Poly(mpc-co-m) Microspheresmentioning

confidence: 99%

Surface Modified Polymer Microspheres Obtained by the Emulsion Copolymerization of 2-Methacryloyloxyethyl Phosphorylcholine with Various Vinyl Monomers

Sugiyama

Aoki

1994

Polym J

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ABSTRACT:A series of copolymer microspheres of2-methacryloyloxyethyl phosphorylcholine (MPC) with comonomers (M) such as methyl-(MMA), ethyl-(EMA), n-butyl-(BMA), hexyl methacrylate (HMA), and styrene (St), poly(MPC-co-M), was prepared from the emulsifier-free emulsion copolymerization. From the kinetics of copolymerization of MPC and MMA, it was found that the initial rate of polymerization of MMA increased drastically in the presence of small amounts of MPC. A decrease in the yield of poly(MPC-co-MMA) microspheres and increase in that of its aggregates were observed with increasing content of the MPC moiety from Oto 10 mo!% in feed. The diameters of poly(MPC-co-M) microspheres were much smaller than those of corresponding poly(M) microspheres except for poly(MMA) microspheres. It was confirmed from XPS measurements that the MPC moiety is localized on the surface of particles. A series of poly(MPC-co-M) microspheres was found to absorb bovine serum albumin (BSA) less than the corresponding poly(M) microspheres as the control. It was concluded that the reduction of adsorbtion of BSA on poly(MPC-co-M) is dependent on the hydrophilicity of comonomer M and the MPC composition on the surface of particles.KEY WORDS Emulsion Copolymerization / 2-Methacryloyloxyethyl Phosphorylcholine / Vinyl Monomers/ Surface Modified Polymer Microspheres / XPS / Albumin Adsorption /

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Adsorption of bovine serum albumin onto homo- and copolymer latices

Cited by 84 publications

References 30 publications

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Studies of Peptide Binding to Allyl Amine and Vinyl Acetic Acid-Modified Polymers Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Surface Modified Polymer Microspheres Obtained by the Emulsion Copolymerization of 2-Methacryloyloxyethyl Phosphorylcholine with Various Vinyl Monomers

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