Adsorption and desorption behaviors of selected endocrine disrupting chemicals in simulated gastrointestinal fluids

Abstract

An in vitro technique using simulated gastrointestinal (GI) fluids was applied to investigate the desorption of selected endocrine disrupting chemicals (EDCs), i.e. bisphenol A (BPA) and 17 α-ethinylestradiol (EE2), from the marine sediment in the digestive environment. The results show that the GI fluids suppressed chemical adsorption and greatly increased the desorption of BPA and EE2 from the sediment. Pepsin in the gastric fluid would compete for the adsorption sites with the adsorbates, and bile salts in the intestinal fluid had a solubilization effect on the chemicals. The amount of chemical release from the sediment in different fluids followed intestinal (fed)>intestinal (fasted)>gastric>saline water. During the dynamic desorption tests, 62% and 21% of sediment-bound BPA and EE2, respectively, could be released into the simulated GI fluids. The enhanced desorption of EDCs from sediment in the digestive system would make the pollutants more bioavailable in the ecosystem.

Interaction processes of ciprofloxacin with graphene oxide and reduced graphene oxide in the presence of montmorillonite in simulated gastrointestinal fluids

“…Therefore, pepsin occupied larger adsorption sites than CIP to decrease further the CIP adsorption on the adsorbents. A similar phenomenon was also reported for the decrease adsorption of other organic chemicals (phenanthrene, bisphenol A, and 17α-ethinylestradiol) in the presence of pepsin in simulated gastric fluid 19, 20 . Hence, the decrease adsorption of CIP on the GO, rGO, and Mont existing in gastric fluid induced animals to uptake free CIP.…”

“…However, the interaction behavior of CIP with rGO/GO in the presence of Mont remains to be reported so far. Several recent studies have reported the adsorption and desorption behaviors of aflatoxin on smectite 18 , phenanthrene on carbon nanotubes 19 , and bisphenol A and 17 α-ethinylestradiol on marine sediment 20 in simulated gastrointestinal fluids. These organic contaminants released from adsorbents in simulated digestive fluids further produce bio-toxicity or threaten environment health.…”

Key Physicochemical Properties Dictating Gastrointestinal Bioaccessibility of Microplastics-Associated Organic Xenobiotics: Insights from a Deep Learning Approach

“…Determination of Bioaccessibility in Simulated Digestive Fluids. Bioaccessibility was assessed with an in vitro digestive model simulating the gastric and small intestinal digestion processes, 32,33 using the recipes of Zhang et al 34 for gastric and intestinal fluids (without including the silicone sheet). The simulated gastric fluid was 10 g/L pepsin in a KCl−HCl solution (0.2 M KCl, pH 1.0).…”

Bioaccessibility of organic compounds associated with tire particles using a fish in vitro digestive model: solubilization kinetics and effects of food co-ingestion

“…Studies investigating direct effects of TRWP remain scarce 21,32,33 which highlights the need to investigate the effects of the particles themselves in addition to the effects of leachates 34 . Indeed, several studies showed that the solubilization of polymer-bound chemicals was enhanced in fish gut fluids compared to water and could promote bioaccessibility of the chemicals for uptake into the circulatory system [35][36][37][38][39][40] . More specifically, we demonstrated in a previous article that bioaccessibility of Zn from tire particles was enhanced by the organic components of the fish gut fluids and assessed the effects of coingestion of food organic matter on Zn bioaccessibility in fish gut 8 .…”