Adropin: A New Marker for Predicting Late Saphenous Vein Graft Disease after Coronary Artery Bypass Grafting

Abstract

Purpose: Saphenous vein graft disease (SVGD), defined as an occlusion of 50% or more of the SVG excluding distal anastomotic occlusion, is an important predictor of morbidity after coronary artery bypass grafting (CABG). Late graft occlusion is a serious complication that often limits the use of the saphenous vein as a coronary bypass graft. Late graft occlusion is particularly common in old, degenerated venous grafts with advanced atherosclerotic plaques. Adropin has been implicated in the homeostatic control of metabolism. The purpose of this study was to investigate whether serum adropin levels are associated with late SVGD following CABG.Methods: Thirty-eight patients with SVGD involving at least one graft (occluded group; 14 females, 24 males) and 42 patients with a patent saphenous vein graft (patent group; 15 females, 27 males) were enrolled in this study. Venous blood samples were taken from all of the participants to measure plasma adropin levels using an enzyme-linked immunsorbent assay kit. Results:The mean adropin level was significantly lower in the occluded group than in the patent group (3.2 ± 0.71 vs. 4.9 ± 1.51 ng/mL, p < 0.001). Multivariate regression analysis showed that the adropin level was the independent predictor of late saphenous vein graft occlusion.Conclusions: Adropin levels are lower in patients with late saphenous vein graft occlusion and these reduced adropin levels, together with other factors, may lead to saphenous vein graft occlusion. Larger and prospective studies are needed to determine if adropin plays a role in the pathogenesis of SVGD.

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

“…Thus, downregulation of adropin in depression may contribute to impaired energy homeostasis in this disease [39]. Finally, low levels of circulating adropin is the predictor of late saphenous vein graft occlusion [40], suggesting that adropin deficiency may contribute to the pathogenesis of saphenous vein graft disease.…”

Inverse association between carbohydrate consumption and plasma adropin concentrations in humans

“…Studies using mice suggest the peptide hormone adropin has metabolic (1-3) and vascular functions (4). Circulating adropin concentrations have been measured in several mammalian species using commercially produced enzyme immunoassays (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Human studies have screened for associations between plasma adropin concentrations and cardiovascular disease (5,8,12,17), endothelial function (10,11), type 2 diabetes (T2D) (7,9,14,17), obesity and aging (6), and exercise response (23).…”

Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

“…Zhao et al (25) revealed that low serum adropin level was associated with hyperhomocysteinemia and more severe coronary atherosclerosis, as reflected by higher SYNTAX score. Demirçelik et al (10) revealed that adropin level is lower in patients with late saphenous vein graft occlusion and these reduced adropin levels. These studies suggested that adropin might have role on progression of atherosclerosis.…”

“…In a recent study, it was found that patients with stable ischemic heart disease have lower adropin concentrations (9). Also, Demirçelik et al (10) reported that adropin level is lower in patients with late saphenous vein graft occlusion.…”